EA201991493A3 - HUMAN ANTIGEN-BINDING PROTEINS THAT BIND WITH Β-CLOTO, FGF RECEPTORS AND THEIR COMPLEXES - Google Patents
HUMAN ANTIGEN-BINDING PROTEINS THAT BIND WITH Β-CLOTO, FGF RECEPTORS AND THEIR COMPLEXESInfo
- Publication number
- EA201991493A3 EA201991493A3 EA201991493A EA201991493A EA201991493A3 EA 201991493 A3 EA201991493 A3 EA 201991493A3 EA 201991493 A EA201991493 A EA 201991493A EA 201991493 A EA201991493 A EA 201991493A EA 201991493 A3 EA201991493 A3 EA 201991493A3
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- binding proteins
- antigen
- fgfr3c
- fgfr1c
- fgfr2c
- Prior art date
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретение предоставляет композиции и способы, относящиеся к антиген-связывающим белкам, активирующим FGF21-опосредованную передачу сигнала, или производным от этих белков. В различных вариантах воплощения антиген-связывающие белки специфично связываются с (i) -Клото; (ii) FGFR1c, FGFR2c, FGFR3c или FGFR4; или (iii) комплексом, содержащим -Клото и одну из молекул FGFR1c, FGFR2c, FGFR3c и FGFR4. В некоторых вариантах воплощения антиген-связывающие белки индуцируют FGF21-подобный сигналлинг. В некоторых вариантах воплощения антиген-связывающие белки являются полностью принадлежащими человеку, гуманизированными или химерными антителами, связывающими фрагментами и производными таких антител, и полипептидами, которые специфично связываются с (i) -Клото; (ii) FGFR1c, FGFR2c, FGFR3c или FGFR4; или (iii) комплексом, содержащим -Клото и одну из молекул FGFR1c, FGFR2c, FGFR3c и FGFR4. В других вариантах воплощения предложены нуклеиновые кислоты, кодирующие такие антиген-связывающие белки и их фрагменты, а также производные и полипептиды, клетки, содержащие такие полинуклеотиды, способы получения таких антиген-связывающих белков, их фрагментов и производных, и полипептидов, и способы применения таких антиген-связывающих белков, их фрагментов и производных, и полипептидов, включая способы лечения или диагностики у субъектов, страдающих диабетом 2 типа, ожирением, НАСГ, метаболическим синдромом и родственными нарушениями или состояниями.The invention provides compositions and methods related to antigen-binding proteins, activating FGF21-mediated signaling, or derived from these proteins. In various embodiments, antigen binding proteins specifically bind to (i) -Cloto; (ii) FGFR1c, FGFR2c, FGFR3c, or FGFR4; or (iii) a complex containing α-Klotho and one of the FGFR1c, FGFR2c, FGFR3c, and FGFR4 molecules. In some embodiments, antigen binding proteins induce FGF21-like signaling. In some embodiments, the antigen binding proteins are wholly human, humanized or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to (i) -Clotho; (ii) FGFR1c, FGFR2c, FGFR3c, or FGFR4; or (iii) a complex containing α-Klotho and one of the FGFR1c, FGFR2c, FGFR3c, and FGFR4 molecules. In other embodiments, there are provided nucleic acids encoding such antigen-binding proteins and fragments thereof, as well as derivatives and polypeptides, cells containing such polynucleotides, methods for producing such antigen-binding proteins, fragments and derivatives thereof, and polypeptides, and methods of using such antigen-binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treatment or diagnosis in subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome, and related disorders or conditions.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38184610P | 2010-09-10 | 2010-09-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201991493A2 EA201991493A2 (en) | 2020-11-30 |
| EA201991493A3 true EA201991493A3 (en) | 2020-12-30 |
Family
ID=73649882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201991493A EA201991493A3 (en) | 2010-09-10 | 2010-12-03 | HUMAN ANTIGEN-BINDING PROTEINS THAT BIND WITH Β-CLOTO, FGF RECEPTORS AND THEIR COMPLEXES |
Country Status (1)
| Country | Link |
|---|---|
| EA (1) | EA201991493A3 (en) |
-
2010
- 2010-12-03 EA EA201991493A patent/EA201991493A3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA201991493A2 (en) | 2020-11-30 |
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