JO3379B1 - Human antigen binding proteins that bind b-klotho, fgf receptors and complexes thereof - Google Patents
Human antigen binding proteins that bind b-klotho, fgf receptors and complexes thereofInfo
- Publication number
- JO3379B1 JO3379B1 JOP/2010/0427A JOP20100427A JO3379B1 JO 3379 B1 JO3379 B1 JO 3379B1 JO P20100427 A JOP20100427 A JO P20100427A JO 3379 B1 JO3379 B1 JO 3379B1
- Authority
- JO
- Jordan
- Prior art keywords
- antigen binding
- binding proteins
- klotho
- fgfr3c
- fgfr1c
- Prior art date
Links
Abstract
The present invention provides compositions and methods relating to or derived from antigen binding proteins activate FGF21-mediated signaling. In embodiments, the antigen binding proteins specifically bind to (i) B-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising B-Klotho and one of FGFR1c, FGFR2c, FGFR3c, and FGFR4. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to (i)B-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising B-Klotho and one of FGFR1c, FGFR2c, FGFR3c, and FGFR4. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26732161A | 2009-12-07 | 2009-12-07 | |
US38184610P | 2010-09-10 | 2010-09-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
JO3379B1 true JO3379B1 (en) | 2019-03-13 |
Family
ID=68233919
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2010/0427A JO3379B1 (en) | 2009-12-07 | 2010-12-01 | Human antigen binding proteins that bind b-klotho, fgf receptors and complexes thereof |
Country Status (1)
Country | Link |
---|---|
JO (1) | JO3379B1 (en) |
-
2010
- 2010-12-01 JO JOP/2010/0427A patent/JO3379B1/en active
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