TH147119A - Binding proteins to human antigens (beta) - Klotho, FGF receptors and their complexes. - Google Patents

Abstract

DC60 (29/08/55) This invention provides elements And methods related or derived from the antigen-mediated signaling protein (protein) of FGF21 as an antigen-binding protein specifically bound to (i) beta-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; Or (iii) a beta-Klotho complex and one of the FGFR1c, FGFR2c, FGFR3c and FGFR4 in some form. Antigen-bound proteins induce signaling similar to FGF21 in some ways. Antigen-bound proteins are fully human antibody, humanized antibody, or chimeric antibody, fracture. Comment that caught each other And its derivatives, and polypeptides, (polypeptide) specific to (i) beta-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; Or (iii) beta-Klotho complexes and one of the FGFR1c, FGFR2c, FGFR3c and other FGFR4 characteristics. A nucleic acid that transcribes the antigen-bound protein, and fragments are provided. And its derivatives, and polypeptides, cells containing such polypeptides, methods for producing proteins that bind to them, and fragments And its derivatives, and polypeptides, including methods for treating or diagnosing test subjects suffering from type 2 diabetes, obesity, NASH, Metabolic syndrome (metabolic syndrome) and related disorders or conditions. This invention provides elements And methods related or derived from the antigen-mediated signaling protein (protein) of FGF21 as an antigen-binding protein specifically bound to (i) (formula) -Klotho. ; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; Or (iii) a complex containing (Recipe) -Klotho And one of the FGFR1c, FGFR2c, FGFR3c and FGFR4. Antigen-bound proteins induce signaling similar to FGF21 in some ways. Antigen-bound proteins are fully human antibody, humanized antibody, or chimeric antibody, fracture. Comment that caught each other And its derivatives, and polypeptides, (polypeptide) specific to (i) (formula) -Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; Or (iii) a complex containing (Recipe) -Klotho And one of the other FGFR1c, FGFR2c, FGFR3c and FGFR4 features. A nucleic acid that transcribes the antigen-bound protein, and fragments are provided. And its derivatives, and polypeptides, cells containing such polypeptides, methods for producing proteins binding to such antigens, and fragments and their derivatives, and poly Lepeptides, which include methods for treating or diagnosing trial participants with type 2 diabetes, obesty, NASH, metabolic syndrome. Drom (metabolic syndrome) and related disorders or conditions.

Claims (3)

1.Protein (protein) bound to isolated antigens that induce FGF21-mediated signaling. 2. The isolated antigen-binding protein to bind specifically to at least one type of: (i) (formula) -Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; And (iii) complexes containing (Recipe) -Klotho And one of the FGFR1c, FGFR2c, FGFR3c and FGFR4, where antigen-binding proteins induce FGF21-mediated signaling. 3. Antigen-bound protein of claim 1, where antigen-bound protein: Drug patent