EA201991472A1 - LOW-MOLECULAR KINASE INHIBITORS JAK FAMILY - Google Patents

LOW-MOLECULAR KINASE INHIBITORS JAK FAMILY

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Publication number
EA201991472A1
EA201991472A1 EA201991472A EA201991472A EA201991472A1 EA 201991472 A1 EA201991472 A1 EA 201991472A1 EA 201991472 A EA201991472 A EA 201991472A EA 201991472 A EA201991472 A EA 201991472A EA 201991472 A1 EA201991472 A1 EA 201991472A1
Authority
EA
Eurasian Patent Office
Prior art keywords
low
kinase inhibitors
jak family
molecular kinase
methods
Prior art date
Application number
EA201991472A
Other languages
Russian (ru)
Other versions
EA037347B1 (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/066744 external-priority patent/WO2018112379A1/en
Publication of EA201991472A1 publication Critical patent/EA201991472A1/en
Publication of EA037347B1 publication Critical patent/EA037347B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Соединения 2-((1r,4r)-4-(имидазо[4,5-d]пирроло[2,3-b]пиридин-1(6H)-ил)циклогексил)ацетонитрила, содержащие их фармацевтические композиции, способы их получения и способы их применения, включая способы лечения заболеваний, расстройств и состояний, опосредованных JAK, таких как воспалительное заболевание кишечника.Compounds 2 - ((1r, 4r) -4- (imidazo [4,5-d] pyrrolo [2,3-b] pyridin-1 (6H) -yl) cyclohexyl) acetonitrile, pharmaceutical compositions containing them, methods for their preparation and methods of using them, including methods of treating diseases, disorders and conditions mediated by JAK, such as inflammatory bowel disease.

EA201991472A 2017-12-08 2017-12-15 Small molecule inhibitors of the jak family of kinases EA037347B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762596607P 2017-12-08 2017-12-08
PCT/US2017/066744 WO2018112379A1 (en) 2016-12-16 2017-12-15 Small molecule inhibitors of the jak family of kinases

Publications (2)

Publication Number Publication Date
EA201991472A1 true EA201991472A1 (en) 2019-11-29
EA037347B1 EA037347B1 (en) 2021-03-16

Family

ID=68653637

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201991472A EA037347B1 (en) 2017-12-08 2017-12-15 Small molecule inhibitors of the jak family of kinases

Country Status (1)

Country Link
EA (1) EA037347B1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2523957A1 (en) * 2010-01-12 2012-11-21 F. Hoffmann-La Roche AG Tricyclic heterocyclic compounds, compositions and methods of use thereof
WO2013007765A1 (en) * 2011-07-13 2013-01-17 F. Hoffmann-La Roche Ag Fused tricyclic compounds for use as inhibitors of janus kinases

Also Published As

Publication number Publication date
EA037347B1 (en) 2021-03-16

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