EA201991473A1 - IMIDAZOPYRROLOPYRIDINE AS AN INHIBITOR KINASE KINASE FAMILY JAK - Google Patents

IMIDAZOPYRROLOPYRIDINE AS AN INHIBITOR KINASE KINASE FAMILY JAK

Info

Publication number
EA201991473A1
EA201991473A1 EA201991473A EA201991473A EA201991473A1 EA 201991473 A1 EA201991473 A1 EA 201991473A1 EA 201991473 A EA201991473 A EA 201991473A EA 201991473 A EA201991473 A EA 201991473A EA 201991473 A1 EA201991473 A1 EA 201991473A1
Authority
EA
Eurasian Patent Office
Prior art keywords
kinase
jak
imidazopyrrolopyridine
inhibitor
family
Prior art date
Application number
EA201991473A
Other languages
Russian (ru)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/066754 external-priority patent/WO2018112382A1/en
Publication of EA201991473A1 publication Critical patent/EA201991473A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Abstract

Соединения 2-((1r,4r)-4-(имидазо[4,5-d]пирроло[2,3-b]пиридин-1(6H)-ил)циклогексил)ацетонитрила, содержащие их фармацевтические композиции, способы их получения и способы их применения, включая способы лечения заболеваний, расстройств и состояний, опосредованных JAK, таких как воспалительное заболевание кишечника.Compounds 2 - ((1r, 4r) -4- (imidazo [4,5-d] pyrrolo [2,3-b] pyridin-1 (6H) -yl) cyclohexyl) acetonitrile, pharmaceutical compositions containing them, methods for their preparation and methods for their use, including methods for treating JAK-mediated diseases, disorders and conditions, such as inflammatory bowel disease.

EA201991473A 2017-12-08 2017-12-15 IMIDAZOPYRROLOPYRIDINE AS AN INHIBITOR KINASE KINASE FAMILY JAK EA201991473A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762596636P 2017-12-08 2017-12-08
PCT/US2017/066754 WO2018112382A1 (en) 2016-12-16 2017-12-15 Imidazopyrrolopyridine as inhibitors of the jak family of kinases

Publications (1)

Publication Number Publication Date
EA201991473A1 true EA201991473A1 (en) 2019-11-29

Family

ID=68653615

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201991473A EA201991473A1 (en) 2017-12-08 2017-12-15 IMIDAZOPYRROLOPYRIDINE AS AN INHIBITOR KINASE KINASE FAMILY JAK

Country Status (1)

Country Link
EA (1) EA201991473A1 (en)

Similar Documents

Publication Publication Date Title
PH12019501355A1 (en) Small molecule inhibitors of the jak family of kinases
PH12019501254A1 (en) Small molecule inhibitors of the jak family of kinases
EA202090659A1 (en) COMPOSITIONS CONTAINING 6- (2-HYDROXY-2-METHYLPROPOXY) -4- (6- (6 - ((6-METOXYPIRIDIN-3-YL) METHYL) -3,6-DIAZABICYCLO [3.1.1] HEPTAN-3- IL) PYRIDIN-3-YL) PYRAZOLO [1,5-a] PYRIDINE-3-CARBONITRILE
GEP20217242B (en) Pyrazolo[1,5-a]pyrazin-4-yl derivatives as jak-inhibitors
PH12020551984A1 (en) Small molecule inhibitors of the jak family of kinases
EA201891067A1 (en) [1,2,4] TRIAZOLO [1,5-a] PYRIMIDIN-7-ILY COMPOUND
EA201991109A1 (en) [1,2,4] TRIAZOLO [1,5-a] PYRIMIDINE DERIVATIVES AS PDE2 INHIBITORS
EA201491520A1 (en) NEW CONNECTIONS OF 3,5-DESIGNED-3H-IMIDAZO [4,5-b] Pyridine and 3,5-DESIGNED-3H- [1,2,3] TRIAZOLO [4,5-b] Pyridine as modulators of C-met PROTEINKINASE
EA201991094A1 (en) COMPOUNDS [1,2,4] TRIAZOLO [1,5-a] PYRIMIDINE AS PDE2 INHIBITORS
EA201990973A1 (en) COMPOUNDS [1,2,4] TRIAZOLO [1,5-a] PYRIMIDINE AS PDE2 INHIBITORS
EA201890922A1 (en) CYCLIC PROSTOFIRY DERIVATIVES OF PYRAZOLO [1,5-A] PYRIMIDIN-3-CARBOXAMIDE
EA201991473A1 (en) IMIDAZOPYRROLOPYRIDINE AS AN INHIBITOR KINASE KINASE FAMILY JAK
EA201991472A1 (en) LOW-MOLECULAR KINASE INHIBITORS JAK FAMILY
EA201792087A1 (en) DERIVATIVES OF 7- (MORFOLIN-4-IL) PYRAZOLO [1,5-a] Pyrimidine, suitable for the treatment of immune or inflammatory diseases or cancer
EA202190047A1 (en) LOW MOLECULAR KINASE INHIBITORS OF THE JAK FAMILY
AR114969A1 (en) SMALL MOLECULE INHIBITORS FROM THE JAK FAMILY OF KINASES
CR20190283A (en) Imidazopirrolopiridina como inhibidores de la familia de quinasas jak
EA201790795A1 (en) COMPOUNDS 4H-PYRIDO [1,2-a] PYRIMIDIN-4-IT
MA50430B1 (en) Imidazo[4,5-d]pyrrolo[2,3-b]pyridine compounds as janus kinase inhibitors