EA201991130A1 - LIQUID PHARMACEUTICAL COMPOSITION FOR PREPARING SOLUTION FOR LOCAL AND EXTERNAL APPLICATION (VERSIONS) AND METHOD FOR ITS PREPARATION - Google Patents

LIQUID PHARMACEUTICAL COMPOSITION FOR PREPARING SOLUTION FOR LOCAL AND EXTERNAL APPLICATION (VERSIONS) AND METHOD FOR ITS PREPARATION

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Publication number
EA201991130A1
EA201991130A1 EA201991130A EA201991130A EA201991130A1 EA 201991130 A1 EA201991130 A1 EA 201991130A1 EA 201991130 A EA201991130 A EA 201991130A EA 201991130 A EA201991130 A EA 201991130A EA 201991130 A1 EA201991130 A1 EA 201991130A1
Authority
EA
Eurasian Patent Office
Prior art keywords
solvent
nitrofural
solution
local
preparation
Prior art date
Application number
EA201991130A
Other languages
Russian (ru)
Other versions
EA038471B1 (en
Inventor
Евгений Федорович Прохода
Елена Юрьевна Ксенофонтова
Антон Павлович Ластовой
Original Assignee
Открытое Акционерное Общество "Фармстандарт-Лексредства"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Открытое Акционерное Общество "Фармстандарт-Лексредства" filed Critical Открытое Акционерное Общество "Фармстандарт-Лексредства"
Priority to EA201991130A priority Critical patent/EA038471B1/en
Publication of EA201991130A1 publication Critical patent/EA201991130A1/en
Publication of EA038471B1 publication Critical patent/EA038471B1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение относится к области медицины, а именно к противомикробному лекарственному препарату в виде концентрированного раствора нитрофурала, который предназначен для приготовления раствора для местного и наружного применения, обладающего противомикробным действием. Композиция содержит действующее вещество нитрофурал, растворитель (ПЭГ-400), сорастворитель (ДМСО, этанол, пропиленгликоль, воду), неионогенное поверхностно-активное вещество и/или антикристаллизатор. Согласно способу получения проводят растворение действующего вещества в растворителе и/или смеси растворителя и сорастворителя, при необходимости добавляя неионогенное ПАВ или антикристаллизатор. Полученный таким способом противомикробный лекарственный препарат применяют при гнойных ранах, пролежнях, мелких повреждениях кожи, в том числе ссадинах, царапинах, трещинах, порезах, инфекционно-воспалительных заболеваниях ротовой полости и горла, в том числе ангине, стоматите, гингивите, тонзиллите. Концентрированный раствор нитрофурала стабилен при хранении в течение двух лет и растворяются в воде при комнатной температуре либо мгновенно, либо за время не более 5 мин в зависимости от композиции.The invention relates to medicine, namely to an antimicrobial drug in the form of a concentrated solution of nitrofural, which is intended for the preparation of a solution for local and external use with antimicrobial action. The composition contains the active ingredient nitrofural, a solvent (PEG-400), a co-solvent (DMSO, ethanol, propylene glycol, water), a nonionic surfactant and / or an anticrystallizer. According to the production method, the active substance is dissolved in a solvent and / or a mixture of solvent and co-solvent, if necessary adding a nonionic surfactant or an anticrystallizer. The antimicrobial drug obtained in this way is used for purulent wounds, bedsores, minor skin lesions, including abrasions, scratches, cracks, cuts, infectious and inflammatory diseases of the mouth and throat, including sore throat, stomatitis, gingivitis, tonsillitis. The concentrated nitrofural solution is stable when stored for two years and dissolves in water at room temperature either instantly or in no more than 5 minutes, depending on the composition.

EA201991130A 2019-06-05 2019-06-05 Liquid pharmaceutical composition for preparation of solution for local and topical application (embodiments) and method for its production EA038471B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EA201991130A EA038471B1 (en) 2019-06-05 2019-06-05 Liquid pharmaceutical composition for preparation of solution for local and topical application (embodiments) and method for its production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EA201991130A EA038471B1 (en) 2019-06-05 2019-06-05 Liquid pharmaceutical composition for preparation of solution for local and topical application (embodiments) and method for its production

Publications (2)

Publication Number Publication Date
EA201991130A1 true EA201991130A1 (en) 2020-12-30
EA038471B1 EA038471B1 (en) 2021-09-02

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201991130A EA038471B1 (en) 2019-06-05 2019-06-05 Liquid pharmaceutical composition for preparation of solution for local and topical application (embodiments) and method for its production

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EA (1) EA038471B1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102210651A (en) * 2011-06-10 2011-10-12 中国人民解放军第八五医院 Nitrofurazone washing fluid, preparation method and application thereof
RU2697056C2 (en) * 2017-07-25 2019-08-09 Федеральное государственное бюджетное образовательное учреждение высшего образования "Курский государственный университет" Method for increasing antibacterial activity of furacin in vitro

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Publication number Publication date
EA038471B1 (en) 2021-09-02

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