EA201892521A1 - РЕМИЕЛИНИЗАЦИЯ ПЕРИФЕРИЧЕСКИХ НЕРВОВ, СТИМУЛИРОВАННАЯ IgG - Google Patents
РЕМИЕЛИНИЗАЦИЯ ПЕРИФЕРИЧЕСКИХ НЕРВОВ, СТИМУЛИРОВАННАЯ IgGInfo
- Publication number
- EA201892521A1 EA201892521A1 EA201892521A EA201892521A EA201892521A1 EA 201892521 A1 EA201892521 A1 EA 201892521A1 EA 201892521 A EA201892521 A EA 201892521A EA 201892521 A EA201892521 A EA 201892521A EA 201892521 A1 EA201892521 A1 EA 201892521A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- peripheral
- polyclonal igg
- remyelinization
- myelin
- differentiation
- Prior art date
Links
- 210000000578 peripheral nerve Anatomy 0.000 title abstract 2
- 208000033808 peripheral neuropathy Diseases 0.000 abstract 4
- 102000006386 Myelin Proteins Human genes 0.000 abstract 2
- 108010083674 Myelin Proteins Proteins 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 230000003210 demyelinating effect Effects 0.000 abstract 2
- 230000004069 differentiation Effects 0.000 abstract 2
- 230000035800 maturation Effects 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 210000005012 myelin Anatomy 0.000 abstract 2
- 208000027232 peripheral nervous system disease Diseases 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000010886 Peripheral nerve injury Diseases 0.000 abstract 1
- 231100000573 exposure to toxins Toxicity 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 201000001119 neuropathy Diseases 0.000 abstract 1
- 230000007823 neuropathy Effects 0.000 abstract 1
- 210000004116 schwann cell Anatomy 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39516—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum from serum, plasma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Abstract
Настоящее изобретение основано на открытии способности поликлональных IgG стимулировать созревание, дифференциацию шванновских клеток и выработку ими миелина. Представлены способы лечения неидиопатических демиелинизирующих периферических нейропатий у млекопитающих, при этом нейропатия не является иммуноопосредованной или инфекционно-опосредованной, путем введения поликлональных IgG. Типы демиелинизирующих периферических нейропатий, подлежащие лечению при помощи настоящего изобретения, включают травму периферического нерва и периферическую нейропатию, вызванную воздействием токсинов. В качестве альтернативы, композицию поликлональных IgG можно наносить непосредственно на периферическую нервную клетку, чтобы стимулировать созревание, дифференциацию в миелинизирующее состояние, экспрессию миелина или способствовать выживанию клеток.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261605117P | 2012-02-29 | 2012-02-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201892521A1 true EA201892521A1 (ru) | 2019-07-31 |
Family
ID=47884569
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201892521A EA201892521A1 (ru) | 2012-02-29 | 2013-02-28 | РЕМИЕЛИНИЗАЦИЯ ПЕРИФЕРИЧЕСКИХ НЕРВОВ, СТИМУЛИРОВАННАЯ IgG |
| EA201400966A EA032000B1 (ru) | 2012-02-29 | 2013-02-28 | Способы лечения демиелинизирующей периферической нейропатии, вызванной травмой |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201400966A EA032000B1 (ru) | 2012-02-29 | 2013-02-28 | Способы лечения демиелинизирующей периферической нейропатии, вызванной травмой |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US8986670B2 (ru) |
| EP (2) | EP3590960B1 (ru) |
| JP (3) | JP6335800B2 (ru) |
| KR (3) | KR102170615B1 (ru) |
| CN (4) | CN109966488A (ru) |
| AR (2) | AR090211A1 (ru) |
| AU (3) | AU2013203088B2 (ru) |
| BR (1) | BR112014021240A2 (ru) |
| DK (2) | DK2820042T3 (ru) |
| EA (2) | EA201892521A1 (ru) |
| ES (2) | ES2943585T3 (ru) |
| FI (1) | FI3590960T3 (ru) |
| HK (2) | HK1206035A1 (ru) |
| IL (3) | IL274512B1 (ru) |
| MX (2) | MX369444B (ru) |
| NZ (1) | NZ629867A (ru) |
| PL (2) | PL2820042T3 (ru) |
| PT (2) | PT2820042T (ru) |
| SG (1) | SG11201405302WA (ru) |
| TW (3) | TWI632158B (ru) |
| WO (1) | WO2013130826A2 (ru) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9690975B2 (en) * | 2015-05-28 | 2017-06-27 | Axogen Corporation | Quantitative structural assay of a nerve graft |
| CN111655336A (zh) | 2017-11-17 | 2020-09-11 | 纽约州立大学研究基金会 | 使用x射线微束辐射治疗受损周围神经的方法 |
| WO2020146370A1 (en) * | 2019-01-07 | 2020-07-16 | Mallinckrodt Ard Ip Limited | Methods of promoting remyelination |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE348942B (ru) | 1970-06-02 | 1972-09-18 | Statens Bakteriologiska Labor | |
| AT376367B (de) | 1983-03-16 | 1984-11-12 | Immuno Ag | Verfahren zur herstellung von therapeutisch verabreichbaren, in endbehaeltern abgefuellten plasmaderivaten |
| DK166763C (da) | 1983-03-16 | 1993-07-12 | Immuno Ag | Immunoglobulin-g-holdig fraktion |
| EP0124506B1 (de) | 1983-05-02 | 1988-08-17 | IMMUNO Aktiengesellschaft für chemisch-medizinische Produkte | Verfahren zur Inaktivierung von vermehrungsfähigen Krankheitserregern |
| AT389815B (de) | 1984-03-09 | 1990-02-12 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten |
| AT390560B (de) | 1986-05-30 | 1990-05-25 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern |
| JP2871709B2 (ja) | 1988-11-21 | 1999-03-17 | 住友製薬株式会社 | 免疫グロブリンｇ結合活性を有する新規な蛋白質プロテインｈ、該蛋白質をコードする遺伝子及び該蛋白質の製造法 |
| US5177194A (en) | 1990-02-01 | 1993-01-05 | Baxter International, Inc. | Process for purifying immune serum globulins |
| WO1992003536A1 (en) * | 1990-08-15 | 1992-03-05 | University Of Miami And Its School Of Medicine | Autotransplantation of schwann cells to promote nervous system repair |
| AT402891B (de) | 1991-06-20 | 1997-09-25 | Immuno Ag | Verfahren zur herstellung eines inaktivierten blutproduktes |
| WO1994013329A1 (de) | 1992-12-16 | 1994-06-23 | Immuno Aktiengesellschaft | Verfahren zur herstellung eines virussicheren biologischen präparates |
| FR2706466B1 (fr) | 1993-06-14 | 1995-08-25 | Aetsrn | Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré. |
| HRP940645A2 (en) | 1993-10-06 | 1996-12-31 | Immuno Ag | Process for virus deactivation in the presence of polyalkylene glycol and the pharmaceutical preparation thus obtained |
| TW491855B (en) | 1996-08-07 | 2002-06-21 | Csl Ltd | Purification of immunoglobulins |
| US5886154A (en) | 1997-06-20 | 1999-03-23 | Lebing; Wytold R. | Chromatographic method for high yield purification and viral inactivation of antibodies |
| IL140155A (en) | 1998-06-09 | 2005-12-18 | Statens Seruminstitut | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products |
| SE0001128D0 (sv) | 2000-03-30 | 2000-03-30 | Amersham Pharm Biotech Ab | A method of producing IgG |
| AU2000261978B2 (en) * | 2000-05-10 | 2006-07-06 | Mayo Foundation For Medical Education And Research | Human igm antibodies with the capability of inducing remyelination, and diagnostic and therapeutic uses thereof particularly in the central nervous system |
| FR2824568B1 (fr) | 2001-05-11 | 2004-04-09 | Lab Francais Du Fractionnement | Procede de preparation de concentres d'immunoglobulines humaines a usage therapeutique |
| JP2003070465A (ja) * | 2001-08-31 | 2003-03-11 | Keio Gijuku | シュワン細胞の培養方法 |
| CA2514117A1 (en) | 2003-01-24 | 2004-08-12 | Elan Pharmaceuticals, Inc. | Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents |
| BRPI0507298A (pt) | 2004-01-30 | 2007-07-03 | Suomen Punainen Risti Veripalv | processo para a produção de imunoglobulina segura a vìrus |
| CN1922207B (zh) | 2004-02-27 | 2012-06-06 | 奥克特珐玛股份有限公司 | 提供纯化的、病毒安全的抗体制剂的方法 |
| WO2008097503A2 (en) * | 2007-02-02 | 2008-08-14 | Biogen Idec Ma Inc. | Use of semaphorin 6a for promoting myelination and oligodendrocyte differentiation |
| US7854703B2 (en) | 2007-09-25 | 2010-12-21 | Intel Corporation | Peripheral neuropathy detection |
| CA2643496C (en) | 2008-11-06 | 2015-02-03 | Michael Fehlings | The therapeutic use of igg as a neuroprotective agent |
| CN102021140B (zh) * | 2009-09-18 | 2013-04-24 | 上海市第一人民医院 | 一种分离、纯化许旺细胞的方法 |
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2013
- 2013-02-28 KR KR1020147027130A patent/KR102170615B1/ko active IP Right Grant
- 2013-02-28 EA EA201892521A patent/EA201892521A1/ru unknown
- 2013-02-28 KR KR1020207030277A patent/KR20200126005A/ko not_active IP Right Cessation
- 2013-02-28 ES ES19180237T patent/ES2943585T3/es active Active
- 2013-02-28 SG SG11201405302WA patent/SG11201405302WA/en unknown
- 2013-02-28 PT PT137096756T patent/PT2820042T/pt unknown
- 2013-02-28 US US13/781,283 patent/US8986670B2/en active Active
- 2013-02-28 CN CN201910008205.7A patent/CN109966488A/zh active Pending
- 2013-02-28 ES ES13709675T patent/ES2755056T3/es active Active
- 2013-02-28 PT PT191802370T patent/PT3590960T/pt unknown
- 2013-02-28 PL PL13709675T patent/PL2820042T3/pl unknown
- 2013-02-28 JP JP2014560045A patent/JP6335800B2/ja active Active
- 2013-02-28 CN CN201380021280.8A patent/CN104302666A/zh active Pending
- 2013-02-28 KR KR1020227011045A patent/KR102673154B1/ko active IP Right Grant
- 2013-02-28 BR BR112014021240A patent/BR112014021240A2/pt not_active Application Discontinuation
- 2013-02-28 CN CN201710896364.6A patent/CN107551269A/zh active Pending
- 2013-02-28 CN CN201910611688.XA patent/CN110343171A/zh active Pending
- 2013-02-28 DK DK13709675T patent/DK2820042T3/da active
- 2013-02-28 EP EP19180237.0A patent/EP3590960B1/en active Active
- 2013-02-28 FI FIEP19180237.0T patent/FI3590960T3/fi active
- 2013-02-28 DK DK19180237.0T patent/DK3590960T3/da active
- 2013-02-28 MX MX2014010387A patent/MX369444B/es active IP Right Grant
- 2013-02-28 EP EP13709675.6A patent/EP2820042B1/en active Active
- 2013-02-28 NZ NZ629867A patent/NZ629867A/en unknown
- 2013-02-28 WO PCT/US2013/028350 patent/WO2013130826A2/en active Application Filing
- 2013-02-28 PL PL19180237.0T patent/PL3590960T3/pl unknown
- 2013-02-28 IL IL274512A patent/IL274512B1/en unknown
- 2013-02-28 EA EA201400966A patent/EA032000B1/ru not_active IP Right Cessation
- 2013-02-28 AU AU2013203088A patent/AU2013203088B2/en active Active
- 2013-03-01 TW TW102107471A patent/TWI632158B/zh active
- 2013-03-01 AR ARP130100662A patent/AR090211A1/es not_active Application Discontinuation
- 2013-03-01 TW TW106122004A patent/TWI700297B/zh active
- 2013-03-01 TW TW107124197A patent/TW201838654A/zh unknown
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2014
- 2014-08-26 IL IL234303A patent/IL234303B/en active IP Right Grant
- 2014-08-28 MX MX2019012496A patent/MX2019012496A/es unknown
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2015
- 2015-02-18 US US14/625,542 patent/US9834593B2/en active Active
- 2015-07-07 HK HK15106445.1A patent/HK1206035A1/xx unknown
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2016
- 2016-02-23 AU AU2016201137A patent/AU2016201137B2/en active Active
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2017
- 2017-09-13 JP JP2017175330A patent/JP6637934B2/ja active Active
- 2017-10-30 US US15/798,313 patent/US10494418B2/en active Active
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2018
- 2018-01-02 AU AU2018200026A patent/AU2018200026B2/en active Active
- 2018-06-25 HK HK18108139.5A patent/HK1248534A1/zh unknown
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2019
- 2019-10-04 JP JP2019183415A patent/JP6979990B2/ja active Active
- 2019-10-18 US US16/657,920 patent/US20200216518A1/en not_active Abandoned
- 2019-11-28 AR ARP190103486A patent/AR117207A2/es unknown
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2020
- 2020-09-02 IL IL277103A patent/IL277103A/en unknown
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2021
- 2021-06-14 US US17/347,380 patent/US20210300997A1/en active Pending
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