EA201891349A1 - Производные гексагидропиразинотриазинона в качестве ингибиторов киназы - Google Patents

Производные гексагидропиразинотриазинона в качестве ингибиторов киназы

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Publication number
EA201891349A1
EA201891349A1 EA201891349A EA201891349A EA201891349A1 EA 201891349 A1 EA201891349 A1 EA 201891349A1 EA 201891349 A EA201891349 A EA 201891349A EA 201891349 A EA201891349 A EA 201891349A EA 201891349 A1 EA201891349 A1 EA 201891349A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
hexagidropyrazinotriasinon
kinase inhibitors
pi4kiiiβ
hexahydropyrazino
Prior art date
Application number
EA201891349A
Other languages
English (en)
Other versions
EA037559B1 (ru
Inventor
Хелен Трейси Хорсли
Ричард Джон Мирс
Джуди Шарлотта Нойсс
Джеймс Томас Рюберсон
Original Assignee
Юсб Байофарма Спрл
Католике Университейт Лёвен
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Юсб Байофарма Спрл, Католике Университейт Лёвен filed Critical Юсб Байофарма Спрл
Publication of EA201891349A1 publication Critical patent/EA201891349A1/ru
Publication of EA037559B1 publication Critical patent/EA037559B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

В заявке описана серия производных 1,2,6,7,9,9a-гексагидропиразино[1,2-d][1,2,4]триазин-4-она, замещенных в положении 8 необязательно замещенной конденсированной бициклической гетероароматической группой и в положении 3 рядом функциональных групп, являющихся селективными ингибиторами активности фосфатидилинозит-4-киназы IIIβ (PI4KIIIβ), полезных для лечения и/или предупреждения различных заболеваний человека, включая воспалительные, аутоиммунные и онкологические нарушения; вирусные заболевания и малярию; и отторжение трансплантата органа и клеток.
EA201891349A 2015-12-10 2016-12-08 Производные гексагидропиразинотриазинона в качестве ингибиторов киназы EA037559B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1521767.2A GB201521767D0 (en) 2015-12-10 2015-12-10 Therapeutic agents
PCT/EP2016/080168 WO2017097871A1 (en) 2015-12-10 2016-12-08 Hexahydropyrazinotriazinone derivatives as kinase inhibitors

Publications (2)

Publication Number Publication Date
EA201891349A1 true EA201891349A1 (ru) 2019-01-31
EA037559B1 EA037559B1 (ru) 2021-04-14

Family

ID=55274503

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201891349A EA037559B1 (ru) 2015-12-10 2016-12-08 Производные гексагидропиразинотриазинона в качестве ингибиторов киназы

Country Status (10)

Country Link
US (1) US10450320B2 (ru)
EP (1) EP3386984B1 (ru)
JP (1) JP6775019B2 (ru)
CN (1) CN108699064B (ru)
BR (1) BR112018011656A2 (ru)
CA (1) CA3007975A1 (ru)
EA (1) EA037559B1 (ru)
ES (1) ES2894680T3 (ru)
GB (1) GB201521767D0 (ru)
WO (1) WO2017097871A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202012616RA (en) 2018-08-21 2021-02-25 Kyorin Pharmaceutical Co Ltd Bicyclic heteroaromatic ring derivative
WO2020132384A1 (en) 2018-12-21 2020-06-25 Celgene Corporation Thienopyridine inhibitors of ripk2

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010103130A2 (en) 2009-03-13 2010-09-16 Katholieke Universiteit Leuven, K.U.Leuven R&D Novel bicyclic heterocycles
EP2417138B1 (en) * 2009-04-09 2019-11-27 Merck Sharp & Dohme Corp. Pyrazolo[1, 5-a]pyrimidine derivatives as mtor inhibitors
GB201012889D0 (en) 2010-08-02 2010-09-15 Univ Leuven Kath Antiviral activity of novel bicyclic heterocycles
GB201015411D0 (en) 2010-09-15 2010-10-27 Univ Leuven Kath Anti-cancer activity of novel bicyclic heterocycles
GB201114212D0 (en) 2011-08-18 2011-10-05 Ucb Pharma Sa Therapeutic agents
GB201115665D0 (en) 2011-09-09 2011-10-26 Univ Leuven Kath Autoimmune and inflammatory disorder therapy
GB201119401D0 (en) * 2011-11-10 2011-12-21 Ucb Pharma Sa Therapeutic agents
GB201217704D0 (en) 2012-10-03 2012-11-14 Ucb Pharma Sa Therapeutic agents
PT2935269T (pt) * 2012-12-20 2018-07-16 Katholieke Univ Leuven K U Leuven R&D Derivados de pirazolo-pirimidina terapeuticamente activos
GB201410817D0 (en) 2014-06-17 2014-07-30 Ucb Biopharma Sprl And Katholieke Universiteit Leuven K U Leuven R & D Therapeutic agents
GB201410815D0 (en) 2014-06-17 2014-07-30 Ucb Biopharma Sprl And Katholieke Universiteit Leuven Therapeutic agents
GB201410816D0 (en) 2014-06-17 2014-07-30 Ucb Biopharma Sprl And Katholieke Universiteit Leuven Therapeutic agents

Also Published As

Publication number Publication date
EA037559B1 (ru) 2021-04-14
EP3386984A1 (en) 2018-10-17
JP2019502678A (ja) 2019-01-31
CN108699064A (zh) 2018-10-23
GB201521767D0 (en) 2016-01-27
EP3386984B1 (en) 2021-08-11
BR112018011656A2 (pt) 2018-12-04
JP6775019B2 (ja) 2020-10-28
CN108699064B (zh) 2021-09-14
US10450320B2 (en) 2019-10-22
ES2894680T3 (es) 2022-02-15
US20180362532A1 (en) 2018-12-20
WO2017097871A1 (en) 2017-06-15
CA3007975A1 (en) 2017-06-15

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