EA201891349A1 - Производные гексагидропиразинотриазинона в качестве ингибиторов киназы - Google Patents
Производные гексагидропиразинотриазинона в качестве ингибиторов киназыInfo
- Publication number
- EA201891349A1 EA201891349A1 EA201891349A EA201891349A EA201891349A1 EA 201891349 A1 EA201891349 A1 EA 201891349A1 EA 201891349 A EA201891349 A EA 201891349A EA 201891349 A EA201891349 A EA 201891349A EA 201891349 A1 EA201891349 A1 EA 201891349A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- derivatives
- hexagidropyrazinotriasinon
- kinase inhibitors
- pi4kiiiβ
- hexahydropyrazino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
В заявке описана серия производных 1,2,6,7,9,9a-гексагидропиразино[1,2-d][1,2,4]триазин-4-она, замещенных в положении 8 необязательно замещенной конденсированной бициклической гетероароматической группой и в положении 3 рядом функциональных групп, являющихся селективными ингибиторами активности фосфатидилинозит-4-киназы IIIβ (PI4KIIIβ), полезных для лечения и/или предупреждения различных заболеваний человека, включая воспалительные, аутоиммунные и онкологические нарушения; вирусные заболевания и малярию; и отторжение трансплантата органа и клеток.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1521767.2A GB201521767D0 (en) | 2015-12-10 | 2015-12-10 | Therapeutic agents |
PCT/EP2016/080168 WO2017097871A1 (en) | 2015-12-10 | 2016-12-08 | Hexahydropyrazinotriazinone derivatives as kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201891349A1 true EA201891349A1 (ru) | 2019-01-31 |
EA037559B1 EA037559B1 (ru) | 2021-04-14 |
Family
ID=55274503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201891349A EA037559B1 (ru) | 2015-12-10 | 2016-12-08 | Производные гексагидропиразинотриазинона в качестве ингибиторов киназы |
Country Status (10)
Country | Link |
---|---|
US (1) | US10450320B2 (ru) |
EP (1) | EP3386984B1 (ru) |
JP (1) | JP6775019B2 (ru) |
CN (1) | CN108699064B (ru) |
BR (1) | BR112018011656A2 (ru) |
CA (1) | CA3007975A1 (ru) |
EA (1) | EA037559B1 (ru) |
ES (1) | ES2894680T3 (ru) |
GB (1) | GB201521767D0 (ru) |
WO (1) | WO2017097871A1 (ru) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112752761B (zh) | 2018-08-21 | 2024-03-29 | 杏林制药株式会社 | 双环杂芳族环衍生物 |
AR117472A1 (es) | 2018-12-21 | 2021-08-11 | Celgene Corp | Inhibidores de tienopiridina de ripk2 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2665277T3 (es) | 2009-03-13 | 2018-04-25 | Katholieke Universiteit Leuven K.U. Leuven R&D | Análogos de purina y su uso como agentes inmunosupresores |
EP2417138B1 (en) * | 2009-04-09 | 2019-11-27 | Merck Sharp & Dohme Corp. | Pyrazolo[1, 5-a]pyrimidine derivatives as mtor inhibitors |
GB201012889D0 (en) | 2010-08-02 | 2010-09-15 | Univ Leuven Kath | Antiviral activity of novel bicyclic heterocycles |
GB201015411D0 (en) | 2010-09-15 | 2010-10-27 | Univ Leuven Kath | Anti-cancer activity of novel bicyclic heterocycles |
GB201114212D0 (en) | 2011-08-18 | 2011-10-05 | Ucb Pharma Sa | Therapeutic agents |
GB201115665D0 (en) | 2011-09-09 | 2011-10-26 | Univ Leuven Kath | Autoimmune and inflammatory disorder therapy |
GB201119401D0 (en) | 2011-11-10 | 2011-12-21 | Ucb Pharma Sa | Therapeutic agents |
GB201217704D0 (en) | 2012-10-03 | 2012-11-14 | Ucb Pharma Sa | Therapeutic agents |
KR102215490B1 (ko) * | 2012-12-20 | 2021-02-15 | 유씨비 바이오파마 에스알엘 | 치료 활성 피라졸로-피리미딘 유도체 |
GB201410816D0 (en) | 2014-06-17 | 2014-07-30 | Ucb Biopharma Sprl And Katholieke Universiteit Leuven | Therapeutic agents |
GB201410815D0 (en) | 2014-06-17 | 2014-07-30 | Ucb Biopharma Sprl And Katholieke Universiteit Leuven | Therapeutic agents |
GB201410817D0 (en) | 2014-06-17 | 2014-07-30 | Ucb Biopharma Sprl And Katholieke Universiteit Leuven K U Leuven R & D | Therapeutic agents |
-
2015
- 2015-12-10 GB GBGB1521767.2A patent/GB201521767D0/en not_active Ceased
-
2016
- 2016-12-08 CN CN201680079122.1A patent/CN108699064B/zh not_active Expired - Fee Related
- 2016-12-08 EP EP16808633.8A patent/EP3386984B1/en active Active
- 2016-12-08 EA EA201891349A patent/EA037559B1/ru unknown
- 2016-12-08 CA CA3007975A patent/CA3007975A1/en not_active Abandoned
- 2016-12-08 BR BR112018011656A patent/BR112018011656A2/pt not_active IP Right Cessation
- 2016-12-08 WO PCT/EP2016/080168 patent/WO2017097871A1/en active Application Filing
- 2016-12-08 ES ES16808633T patent/ES2894680T3/es active Active
- 2016-12-08 JP JP2018530112A patent/JP6775019B2/ja not_active Expired - Fee Related
- 2016-12-08 US US16/060,486 patent/US10450320B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP6775019B2 (ja) | 2020-10-28 |
EP3386984B1 (en) | 2021-08-11 |
ES2894680T3 (es) | 2022-02-15 |
WO2017097871A1 (en) | 2017-06-15 |
GB201521767D0 (en) | 2016-01-27 |
EP3386984A1 (en) | 2018-10-17 |
EA037559B1 (ru) | 2021-04-14 |
CA3007975A1 (en) | 2017-06-15 |
CN108699064A (zh) | 2018-10-23 |
CN108699064B (zh) | 2021-09-14 |
US20180362532A1 (en) | 2018-12-20 |
JP2019502678A (ja) | 2019-01-31 |
BR112018011656A2 (pt) | 2018-12-04 |
US10450320B2 (en) | 2019-10-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201890827A1 (ru) | Конденсированные производные пиразола в качестве ингибиторов киназы | |
CL2016001895A1 (es) | Compuestos | |
CY1119588T1 (el) | Εκλεκτικοι αναστολεις pi3κ δελτα | |
BR112016029630A2 (pt) | derivados heteroaromáticos bicíclicos fundidos como inibidores de inibidores de cinase | |
BR112019010222A8 (pt) | Polimorfos de sepiapterina e sais dos mesmos | |
EA201592199A1 (ru) | Производные бипиразола в качестве ингибиторов jak | |
CY1120415T1 (el) | Θεραπευτικα δραστικα παραγωγα πυραζολο-πυριμιδινης | |
BR112019005969A2 (pt) | inibidores seletivos de jak1 inovadores e usos dos mesmos | |
CY1119063T1 (el) | Υποκατασταθεισες δικυκλικες διυδροπυριμιδινονες και η χρηση τους ως αναστολεις της δραστικοτητας ελαστασης ουδετεροφιλων | |
UY36265A (es) | “derivados de pirrolo[2,3-d]pirimidina”. | |
CO2018013803A2 (es) | 1h-pirazolo[4,3-b]piridinas como inhibidores de pde1 | |
BR112016029632A2 (pt) | derivados heteroaromáticos bicíclicos fundidos como inibidores de cinase | |
EA201890626A1 (ru) | ЗАМЕЩЕННЫЕ 1,2-ДИГИДРО-3H-ПИРРОЛО[1,2-c]ИМИДАЗОЛ-3-ОНОВЫЕ АНТИБАКТЕРИАЛЬНЫЕ СОЕДИНЕНИЯ | |
CL2019002605A1 (es) | Formulaciones que contienen proteínas de unión pd-1 y métodos de fabricación de las mismas. | |
ECSP17010481A (es) | Novedosas pirimidinas 2,5-sustituidas | |
FR22C1058I2 (fr) | Formulation de comprimé de 2-fluoro-n-méthyl-4-[7-(quinoline -6-ylméthyl) imidazo[1,2-b][1,2,4]triazine -2-yl]benzamide | |
HK1247923A1 (zh) | 可用作哺乳動物酪氨酸激酶ror1活性抑制劑的2-苯基-3h-咪唑並[4,5-b]吡啶衍生物 | |
TR201901338T4 (tr) | Kinaz İnhibitörleri Olarak Pirazolo-Piridin Türevleri | |
CY1121933T1 (el) | Υποκατεστημενες δικυκλικες διυδροπυριμιδινονες και χρηση αυτων ως αναστολεις δραστικοτητας ελαστασης ουδετεροφιλου | |
ECSP17010482A (es) | Novedosas pirimidinas 2,5-sustituidas | |
CO2017010621A2 (es) | Compuestos bicíclicos fusionados para el tratamiento de enfermedades | |
CL2016000939A1 (es) | Compuestos derivados de pirimidina con actividad inhibidora de syk uso en el tratamiento de una condición inmune, enfermedades inflamatorias, trastornos alérgicos, lupus eritomatosos, epoc, bronquitis, rinitis alérgica, asma, entre otras composición farmacéutica que los comprende. | |
EA201791294A1 (ru) | 7-(МОРФОЛИНИЛ)-2-(N-ПИПЕРАЗИНИЛ)МЕТИЛТИЕНО[2,3-c]ПИРИДИНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ПРОТИВОРАКОВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВ | |
EA201891349A1 (ru) | Производные гексагидропиразинотриазинона в качестве ингибиторов киназы | |
EA202091691A1 (ru) | ТВЕРДЫЕ ФОРМЫ ЗАМЕЩЕННЫХ 5,6-ДИГИДРО-6-ФЕНИЛБЕНЗО[f]ИЗОХИНОЛИН-2-АМИНОВЫХ СОЕДИНЕНИЙ |