EA201890013A1 - Способы получения tcr гамма дельтат-клеток - Google Patents
Способы получения tcr гамма дельтат-клетокInfo
- Publication number
- EA201890013A1 EA201890013A1 EA201890013A EA201890013A EA201890013A1 EA 201890013 A1 EA201890013 A1 EA 201890013A1 EA 201890013 A EA201890013 A EA 201890013A EA 201890013 A EA201890013 A EA 201890013A EA 201890013 A1 EA201890013 A1 EA 201890013A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cells
- methods
- deltat
- tcr gamma
- obtaining tcr
- Prior art date
Links
- 230000001902 propagating effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/32—T-cell receptors [TCR]
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/23—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/2302—Interleukin-2 (IL-2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/23—Interleukins [IL]
- C12N2501/2307—Interleukin-7 (IL-7)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2501/23—Interleukins [IL]
- C12N2501/2321—Interleukin-21 (IL-21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
- C12N2506/115—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells from monocytes, from macrophages
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT2015047568 | 2015-06-09 | ||
| PT2016032002 | 2016-05-12 | ||
| PCT/EP2016/063077 WO2016198480A1 (en) | 2015-06-09 | 2016-06-08 | Methods for the production of tcr gamma delta+ t cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201890013A1 true EA201890013A1 (ru) | 2018-07-31 |
Family
ID=56132913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201890013A EA201890013A1 (ru) | 2015-06-09 | 2016-06-08 | Способы получения tcr гамма дельтат-клеток |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11166983B2 (enExample) |
| EP (2) | EP3307875B1 (enExample) |
| JP (1) | JP6799895B2 (enExample) |
| CN (2) | CN114958738A (enExample) |
| AU (3) | AU2016274633B2 (enExample) |
| CA (1) | CA2988050A1 (enExample) |
| EA (1) | EA201890013A1 (enExample) |
| WO (1) | WO2016198480A1 (enExample) |
| ZA (1) | ZA201800121B (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2756247C2 (ru) | 2014-11-17 | 2021-09-28 | Эдисет Био, Инк. | Генетически модифицированные гамма дельта т-клетки |
| KR20240063197A (ko) | 2015-06-09 | 2024-05-09 | 감마델타 테라퓨틱스 엘티디 | Tcr 감마 델타 양성 t 세포의 생산 방법 |
| CN108473958A (zh) * | 2015-10-30 | 2018-08-31 | 癌症研究技术有限公司 | 非造血组织驻留γδT细胞的扩增及这些细胞的用途 |
| CN118421557A (zh) | 2016-05-12 | 2024-08-02 | 阿迪塞特治疗公司 | 选择性扩增γδT细胞群的方法及其组合物 |
| JP7002769B2 (ja) * | 2016-09-16 | 2022-02-04 | ベイラー カレッジ オブ メディスン | ウイルス特異的t細胞の活性化および拡大のためのプラットフォーム |
| GB201707048D0 (en) * | 2017-05-03 | 2017-06-14 | King S College London | Expansion of gamma delta cells, compositions, and methods of use thereof |
| WO2018229163A1 (en) * | 2017-06-14 | 2018-12-20 | King's College London | Methods of activating v delta 2 negative gamma delta t cells |
| CA3082818A1 (en) * | 2017-11-15 | 2019-05-23 | Adicet Bio Inc. | Methods for selective expansion of .delta.3 .gamma..delta. t-cell populations and compositions thereof |
| WO2019147735A1 (en) | 2018-01-23 | 2019-08-01 | New York University | Antibodies specific to delta 1 chain of t cell receptor |
| GB201804701D0 (en) | 2018-03-23 | 2018-05-09 | Gammadelta Therapeutics Ltd | Lymphocytes expressing heterologous targeting constructs |
| BR112021006182A2 (pt) | 2018-10-01 | 2021-06-29 | Adicet Bio, Inc. | composições e métodos relativos a células t¿d,d engenheiradas e não engenheiradas para tratamento de tumores hematológicos |
| US12698340B2 (en) | 2018-10-01 | 2026-08-04 | Adicet Therapeutics, Inc. | Compositions and methods regarding engineered and non-engineered γδ T-cells for treatment of solid tumors |
| GB201818243D0 (en) | 2018-11-08 | 2018-12-26 | Gammadelta Therapeutics Ltd | Methods for isolating and expanding cells |
| CA3127103A1 (en) | 2019-01-23 | 2020-07-30 | New York University | Antibodies specific to delta 1 chain of t cell receptor |
| US20220088074A1 (en) * | 2019-02-21 | 2022-03-24 | Regents Of The University Of Minnesota | Genetically modified gamma delta t cells and methods of making and using |
| CA3143198A1 (en) * | 2019-06-14 | 2020-12-17 | G Tech Bio Llc | Activated lymphocytic cells and methods of using the same to treat cancer and infectious conditions |
| JP2022545196A (ja) | 2019-08-16 | 2022-10-26 | ガンマデルタ セラピューティクス リミテッド | 抗tcrデルタ可変1抗体の治療的使用 |
| CA3148588A1 (en) | 2019-08-16 | 2021-02-25 | GammaDelta Therapeutics Limited | Ex vivo gamma delta t cell populations |
| CN114555785B (zh) * | 2019-10-17 | 2024-12-06 | 香港大学 | 制备v-t细胞衍生的外泌体以治疗epstein-barr病毒相关癌症的方法 |
| LT4051710T (lt) | 2019-10-31 | 2026-03-10 | Incyte Corporation | Priešnavikinė kompleksinė terapija, apimanti anti-cd19 antikūną ir gama delta ląsteles |
| GB202002581D0 (en) * | 2020-02-24 | 2020-04-08 | Gammadelta Therapeutics Ltd | Novel antibodies |
| US20210290674A1 (en) * | 2020-03-20 | 2021-09-23 | GammaDelta Therapeutics Ltd. | Methods for treating myeloid malignancies |
| WO2021186137A1 (en) | 2020-03-20 | 2021-09-23 | GammaDelta Therapeutics Limited | V delta1+ t cells for the treatment of myeloid malignancies |
| GB202006989D0 (en) * | 2020-05-12 | 2020-06-24 | Gammadelta Therapeutics Ltd | Methods for isolating gamma delta t cells |
| CN113913384A (zh) * | 2020-07-09 | 2022-01-11 | 杭州优凯瑞医药科技有限公司 | 一种制备靶点特异性nk细胞的方法及其应用 |
| ES2943063T5 (en) | 2020-08-14 | 2026-05-05 | Gammadelta Therapeutics Ltd | Multispecific anti-tcr delta variable 1 antibodies |
| US20230302132A1 (en) * | 2020-08-14 | 2023-09-28 | Shanghai Xinghua Bio Pharmaceutical Science & Technology Co., Ltd | Method for preparing universal immune cells and use thereof |
| CA3202233A1 (en) * | 2020-11-18 | 2022-05-27 | Kiromic BioPharma, Inc. | Gamma-delta t cell manufacturing processes and chimeric pd1 receptor molecules |
| KR20230160253A (ko) | 2021-02-17 | 2023-11-23 | 감마델타 테라퓨틱스 엘티디 | 항-tcr 델타 가변 1 항체 |
| MX2023009544A (es) | 2021-02-17 | 2023-11-28 | Gammadelta Therapeutics Ltd | Anticuerpos anti-variable delta 1 de tcr multiespecíficos. |
| CA3228168A1 (en) | 2021-08-03 | 2023-02-09 | Gammadelta Therapeutics Ltd | Engineering of gamma delta t cells and compositions thereof |
| CA3250985A1 (en) | 2022-02-16 | 2023-08-24 | Priothera Sas | CAR CELL TREATMENT METHODS IN COMBINATION WITH S1P RECEIVER MODULATORS |
| PE20242341A1 (es) | 2022-04-04 | 2024-12-12 | Gammadelta Therapeutics Ltd | Blindaje genetico novedoso |
| GB202204926D0 (en) | 2022-04-04 | 2022-05-18 | Gammadelta Therapeutics Ltd | Method for expanding gammadelta T cells |
| US11750950B1 (en) * | 2022-05-26 | 2023-09-05 | Omnivision Technologies, Inc. | Voltage domain global shutter readout circuit timing |
| CN115678846B (zh) * | 2022-09-01 | 2023-06-16 | 广东龄值生物科技有限公司 | 一种肿瘤特异性γδT细胞及其制备方法 |
| EP4680729A1 (en) * | 2023-03-17 | 2026-01-21 | Legend Biotech Ireland Limited | Methods of culturing v delta 1 t cells |
| WO2024209429A1 (en) | 2023-04-07 | 2024-10-10 | Takeda Pharmaceutical Company Limited | T cells for use in treating relapsed or refractory acute myeloid leukemia |
| WO2026013616A1 (en) * | 2024-07-10 | 2026-01-15 | Takeda Pharmaceutical Company Limited | Compositions and methods for treating cancer |
| WO2026033421A1 (en) | 2024-08-05 | 2026-02-12 | Takeda Pharmaceutical Company Limited | IDENTIFICATION OF SUITABLE DONORS OF γδ T CELLS |
| WO2026088163A1 (en) | 2024-10-25 | 2026-04-30 | Takeda Pharmaceutical Company Limited | Compositions of engineered cytokine expressing cells and methods of use thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ511760A (en) * | 1998-11-04 | 2003-10-31 | Hemosol Inc | Methods for the production of TcR gamma delta T cells |
| ES2336302T3 (es) * | 2000-04-03 | 2010-04-12 | Therapure Biopharma Inc. | Produccion de celulas ttcr gamma delta. |
| US20030157060A1 (en) | 2000-04-03 | 2003-08-21 | Bell David N | Production of tcr gamma delta t cells |
| ATE476497T1 (de) * | 2004-08-19 | 2010-08-15 | Univ Cardiff | Präparation antigenpräsentierender menschlicher gamma delta t-zellen und verwendung in der immuntherapie |
| CA2629532C (en) * | 2005-11-18 | 2016-08-09 | University Health Network | Method of expanding double negative t cells |
| JPWO2008111430A1 (ja) * | 2007-03-09 | 2010-06-24 | タカラバイオ株式会社 | γδT細胞集団の製造方法 |
| RS55730B1 (sr) | 2010-10-21 | 2017-07-31 | Syngenta Ltd | Agrohemijski koncentrati koji sadrže alkoksilovane dodatke |
| EP2710123B1 (en) * | 2011-05-19 | 2017-07-12 | Instituto de Medicina Molecular | Cell line of lymphocytes comprising gamma-delta t cells, composition and production method thereof |
| US9907820B2 (en) * | 2013-10-25 | 2018-03-06 | Board Of Regents, The University Of Texas System | Polyclonal gamma delta T cells for immunotherapy |
| AU2017298142B2 (en) | 2016-07-18 | 2021-11-11 | Arthrosi Therapeutics, Inc. | Compounds, compositions and methods for treating or preventing a symptom associated with gout or hyperuricemia |
| CN106399245A (zh) * | 2016-11-30 | 2017-02-15 | 广州赛莱拉干细胞科技股份有限公司 | 一种γδT细胞的培养方法 |
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2016
- 2016-06-08 JP JP2017564369A patent/JP6799895B2/ja active Active
- 2016-06-08 US US15/735,371 patent/US11166983B2/en active Active
- 2016-06-08 CN CN202210397884.3A patent/CN114958738A/zh active Pending
- 2016-06-08 EP EP16729531.0A patent/EP3307875B1/en active Active
- 2016-06-08 EA EA201890013A patent/EA201890013A1/ru unknown
- 2016-06-08 CN CN201680047265.4A patent/CN108350428B/zh active Active
- 2016-06-08 EP EP19207256.9A patent/EP3623468A1/en active Pending
- 2016-06-08 CA CA2988050A patent/CA2988050A1/en active Pending
- 2016-06-08 WO PCT/EP2016/063077 patent/WO2016198480A1/en not_active Ceased
- 2016-06-08 AU AU2016274633A patent/AU2016274633B2/en active Active
-
2018
- 2018-01-08 ZA ZA2018/00121A patent/ZA201800121B/en unknown
-
2022
- 2022-07-15 AU AU2022205271A patent/AU2022205271A1/en not_active Abandoned
-
2024
- 2024-11-21 US US18/955,830 patent/US20250152630A1/en active Pending
-
2025
- 2025-04-23 AU AU2025202866A patent/AU2025202866A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN108350428B (zh) | 2022-04-22 |
| CA2988050A1 (en) | 2016-12-15 |
| AU2016274633A1 (en) | 2018-02-01 |
| JP6799895B2 (ja) | 2020-12-16 |
| AU2022205271A1 (en) | 2022-08-11 |
| CN108350428A (zh) | 2018-07-31 |
| US11166983B2 (en) | 2021-11-09 |
| HK1245831A1 (zh) | 2018-08-31 |
| WO2016198480A1 (en) | 2016-12-15 |
| ZA201800121B (en) | 2019-08-28 |
| JP2018516586A (ja) | 2018-06-28 |
| AU2016274633B2 (en) | 2022-04-21 |
| EP3623468A1 (en) | 2020-03-18 |
| CN114958738A (zh) | 2022-08-30 |
| US20180169147A1 (en) | 2018-06-21 |
| EP3307875B1 (en) | 2021-12-15 |
| AU2025202866A1 (en) | 2025-05-15 |
| NZ738912A (en) | 2025-05-02 |
| US20250152630A1 (en) | 2025-05-15 |
| EP3307875A1 (en) | 2018-04-18 |
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