EA201790603A1 - Ингибиторы гистондеметилазы - Google Patents

Ингибиторы гистондеметилазы

Info

Publication number
EA201790603A1
EA201790603A1 EA201790603A EA201790603A EA201790603A1 EA 201790603 A1 EA201790603 A1 EA 201790603A1 EA 201790603 A EA201790603 A EA 201790603A EA 201790603 A EA201790603 A EA 201790603A EA 201790603 A1 EA201790603 A1 EA 201790603A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cancer
compounds
compositions
useful
treatment
Prior art date
Application number
EA201790603A
Other languages
English (en)
Russian (ru)
Inventor
Амок Болоор
Тоуфайк Каноуни
Джеффри Алан Стэффорд
Джеймс Марвин Вил
Майкл Бреннан Уоллэс
Original Assignee
Селджен Квонтисел Рисёрч, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Селджен Квонтисел Рисёрч, Инк. filed Critical Селджен Квонтисел Рисёрч, Инк.
Publication of EA201790603A1 publication Critical patent/EA201790603A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EA201790603A 2014-09-17 2015-09-16 Ингибиторы гистондеметилазы EA201790603A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462051691P 2014-09-17 2014-09-17
PCT/US2015/050432 WO2016044429A1 (en) 2014-09-17 2015-09-16 Histone demethylase inhibitors

Publications (1)

Publication Number Publication Date
EA201790603A1 true EA201790603A1 (ru) 2017-10-31

Family

ID=55525128

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790603A EA201790603A1 (ru) 2014-09-17 2015-09-16 Ингибиторы гистондеметилазы

Country Status (17)

Country Link
US (7) US9643965B2 (https=)
EP (2) EP3453710B1 (https=)
JP (1) JP6552608B2 (https=)
KR (1) KR20170048591A (https=)
CN (1) CN107205391A (https=)
AU (1) AU2015317806A1 (https=)
BR (1) BR112017005511A2 (https=)
CA (1) CA2961610A1 (https=)
CL (1) CL2017000659A1 (https=)
CO (1) CO2017003538A2 (https=)
EA (1) EA201790603A1 (https=)
EC (1) ECSP17023551A (https=)
ES (1) ES2910226T3 (https=)
IL (1) IL251179A0 (https=)
MX (1) MX2017003466A (https=)
SG (1) SG11201702147TA (https=)
WO (1) WO2016044429A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20171609T1 (hr) 2013-03-15 2017-12-15 Quanticel Pharmaceuticals Inc Inhibitori histon demetilaze
US9643965B2 (en) 2014-09-17 2017-05-09 Celgene Quantical Research, Inc. Histone demethylase inhibitors
JP6970681B2 (ja) * 2016-03-15 2021-11-24 セルジーン クオンティセル リサーチ，インク． ヒストンデメチラーゼ阻害剤
US10150754B2 (en) 2016-04-19 2018-12-11 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
SI3546456T1 (sl) 2016-11-28 2022-04-29 Teijin Pharma Limited Kristal derivata pirido(3,4-D)pirimidina ali njegovega solvata
US11040973B2 (en) 2017-03-29 2021-06-22 Purdue Research Foundation Inhibitors of kinase networks and uses thereof
WO2020113094A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
EP4074317A1 (en) 2021-04-14 2022-10-19 Bayer AG Phosphorus derivatives as novel sos1 inhibitors
CN115368252B (zh) * 2022-09-19 2024-01-12 西北农林科技大学 一种4-胺基酚类衍生物及应用
CN116253712B (zh) * 2023-03-27 2025-05-02 昆山市第一人民医院 5,6,7-三甲氧基-2,3-二氢喹啉类化合物、药物组合物及用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1447405A4 (en) * 2001-10-17 2005-01-12 Kirin Brewery CHINOLIN OR CHINAZOLINE DERIVATIVES THAT PREVENT THE AUTOPHOSPHORYLATION OF RECEPTORS FOR THE FIBROBLAST GROWTH FACTOR
AU2003218215A1 (en) * 2002-03-15 2003-09-29 Vertex Pharmaceuticals, Inc. Azolylaminoazines as inhibitors of protein kinases
CA2527017A1 (en) * 2003-05-27 2004-12-09 Pfizer Products Inc. Quinazolines and pyrido [3,4-d] pyrimidines as receptor tyrosine kinase inhibitors
US7544677B2 (en) * 2004-08-23 2009-06-09 Merck & Co., Inc. Inhibitors of Akt activity
FR2876103B1 (fr) 2004-10-01 2008-02-22 Aventis Pharma Sa Nouveaux derives bis-azaindoles, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
EP2061772A4 (en) 2006-09-11 2011-06-29 Curis Inc MULTIFUNCTIONAL SMALL MOLECULES AS PROLIFERATION-ACTIVE ACTIVE SUBSTANCES
TW200922590A (en) 2007-09-10 2009-06-01 Curis Inc VEGFR inhibitors containing a zinc binding moiety
JP5552608B2 (ja) 2012-04-27 2014-07-16 株式会社ソフイア 遊技機
RS55764B1 (sr) 2012-10-02 2017-07-31 Gilead Sciences Inhibitori histonskih demetilaza
US8969343B2 (en) 2012-12-19 2015-03-03 Quanticel Pharmaceuticals, Inc. Histone demethylase inhibitors
WO2014100818A1 (en) 2012-12-21 2014-06-26 Quanticel Pharmaceuticals, Inc. Histone demethylase inhibitors
JP6320506B2 (ja) 2013-03-12 2018-05-09 セルジーン クオンティセル リサーチ，インク． ヒストンデメチラーゼ阻害剤
HRP20171609T1 (hr) 2013-03-15 2017-12-15 Quanticel Pharmaceuticals Inc Inhibitori histon demetilaze
WO2014144850A1 (en) 2013-03-15 2014-09-18 Genentech, Inc. Methods of treating cancer and preventing cancer drug resistance
AR100997A1 (es) 2014-06-25 2016-11-16 Quanticel Pharmaceuticals Inc Derivados de piridina como inhibidores de histona demetilasa
US9643965B2 (en) * 2014-09-17 2017-05-09 Celgene Quantical Research, Inc. Histone demethylase inhibitors
US10030017B2 (en) 2014-09-17 2018-07-24 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
JP6970681B2 (ja) 2016-03-15 2021-11-24 セルジーン クオンティセル リサーチ，インク． ヒストンデメチラーゼ阻害剤

Also Published As

Publication number Publication date
US9643965B2 (en) 2017-05-09
EP3193601A4 (en) 2018-07-04
US10815234B2 (en) 2020-10-27
US20170240546A1 (en) 2017-08-24
EP3453710A1 (en) 2019-03-13
BR112017005511A2 (pt) 2018-08-14
KR20170048591A (ko) 2017-05-08
JP6552608B2 (ja) 2019-07-31
ECSP17023551A (es) 2017-05-31
EP3193601B1 (en) 2022-01-05
JP2017529346A (ja) 2017-10-05
CO2017003538A2 (es) 2017-07-28
US20200199122A1 (en) 2020-06-25
US20210009585A1 (en) 2021-01-14
US20190023704A1 (en) 2019-01-24
AU2015317806A1 (en) 2017-04-13
US10112940B2 (en) 2018-10-30
US11535616B2 (en) 2022-12-27
CL2017000659A1 (es) 2018-05-11
US20160083379A1 (en) 2016-03-24
CN107205391A (zh) 2017-09-26
WO2016044429A1 (en) 2016-03-24
EP3453710B1 (en) 2022-09-21
SG11201702147TA (en) 2017-04-27
EP3193601A1 (en) 2017-07-26
ES2910226T3 (es) 2022-05-12
US20250066355A1 (en) 2025-02-27
US12172998B2 (en) 2024-12-24
MX2017003466A (es) 2017-07-13
US10611763B2 (en) 2020-04-07
US20230117519A1 (en) 2023-04-20
CA2961610A1 (en) 2016-03-24
IL251179A0 (en) 2017-05-29

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