EA201691555A1 - Способы лечения и предотвращения заболеваний почек и жировых дистрофий печени - Google Patents
Способы лечения и предотвращения заболеваний почек и жировых дистрофий печениInfo
- Publication number
- EA201691555A1 EA201691555A1 EA201691555A EA201691555A EA201691555A1 EA 201691555 A1 EA201691555 A1 EA 201691555A1 EA 201691555 A EA201691555 A EA 201691555A EA 201691555 A EA201691555 A EA 201691555A EA 201691555 A1 EA201691555 A1 EA 201691555A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- dystrophies
- liver
- fatial
- prevention
- Prior art date
Links
- 210000004185 liver Anatomy 0.000 title abstract 2
- 208000017169 kidney disease Diseases 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 239000005541 ACE inhibitor Substances 0.000 abstract 1
- 102000000536 PPAR gamma Human genes 0.000 abstract 1
- 108010016731 PPAR gamma Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 abstract 1
- 229960001713 canagliflozin Drugs 0.000 abstract 1
- VHOFTEAWFCUTOS-TUGBYPPCSA-N canagliflozin hydrate Chemical compound O.CC1=CC=C([C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C=C1CC(S1)=CC=C1C1=CC=C(F)C=C1.CC1=CC=C([C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C=C1CC(S1)=CC=C1C1=CC=C(F)C=C1 VHOFTEAWFCUTOS-TUGBYPPCSA-N 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 abstract 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461934003P | 2014-01-31 | 2014-01-31 | |
| US201461948882P | 2014-03-06 | 2014-03-06 | |
| PCT/US2015/013644 WO2015116880A1 (en) | 2014-01-31 | 2015-01-30 | Methods for the treatment and prevention of renal disorders and fatty liver disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201691555A1 true EA201691555A1 (ru) | 2017-01-30 |
Family
ID=52544570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201691555A EA201691555A1 (ru) | 2014-01-31 | 2015-01-30 | Способы лечения и предотвращения заболеваний почек и жировых дистрофий печени |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20160339047A1 (enExample) |
| EP (1) | EP3099328A1 (enExample) |
| JP (2) | JP2017504649A (enExample) |
| KR (1) | KR20160107344A (enExample) |
| CN (3) | CN113144204A (enExample) |
| AU (2) | AU2015210898A1 (enExample) |
| CA (1) | CA2938406A1 (enExample) |
| EA (1) | EA201691555A1 (enExample) |
| IL (1) | IL246779A0 (enExample) |
| MX (1) | MX2016010011A (enExample) |
| WO (1) | WO2015116880A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2018113437A (ru) * | 2015-09-16 | 2019-10-17 | Тобира Терапьютикс, Инк. | Комбинированная терапия с использованием ценикривирока для лечения фиброза |
| ES2979120T3 (es) * | 2015-11-06 | 2024-09-24 | Gelteq Ltd | Método y producto para evaluar la respuesta a una carga oral de glucosa |
| GB201614455D0 (en) | 2016-08-24 | 2016-10-05 | Univ Oxford Innovation Ltd | Biomarkers |
| TWI835735B (zh) * | 2017-06-12 | 2024-03-21 | 比利時商健生藥品公司 | 減少或預防第ii型糖尿病患者中心血管事件之方法 |
| CN109806397A (zh) * | 2017-11-20 | 2019-05-28 | 江苏恒瑞医药股份有限公司 | Sglt2抑制剂与arb联合在制备治疗高血压等疾病的药物中的用途 |
| ES3035734T3 (en) | 2017-11-30 | 2025-09-08 | Idorsia Pharmaceuticals Ltd | Combination of a 4-pyrimidinesulfamide derivative with an sglt-2 inhibitor for the treatment of endothelin related diseases |
| TW202103709A (zh) * | 2019-03-26 | 2021-02-01 | 比利時商健生藥品公司 | 用於治療患有慢性腎臟病之對象的方法 |
| CN110051851A (zh) * | 2019-05-31 | 2019-07-26 | 江苏苏中药业集团股份有限公司 | 一种钠-葡萄糖共转运蛋白-2抑制剂与黄蜀葵花提取物的组合 |
| KR20230057388A (ko) * | 2020-08-17 | 2023-04-28 | 티엔진 크레아트론 바이오테크놀로지 컴파니 리미티드 | Sglt-2 억제제와 안지오텐신 수용체 길항제의 조성물 및 이의 용도 |
| IL301831A (en) * | 2020-10-30 | 2023-06-01 | Resverlogix Corp | Methods for improving renal function with a combination of a bet bromodomain inhibitor and a sodium dependent glucose transport 2 inhibitor |
| WO2022104621A1 (zh) * | 2020-11-19 | 2022-05-27 | 北京睿创康泰医药研究院有限公司 | 固定剂量的sglt-2抑制剂与血管紧张素转化酶抑制剂的组合物及用途 |
| JP2024094532A (ja) | 2022-12-28 | 2024-07-10 | キヤノン株式会社 | 撮像設定装置および撮像装置 |
| KR20240126452A (ko) * | 2023-02-10 | 2024-08-21 | 가천대학교 산학협력단 | 칸데사르탄 또는 아질사르탄을 포함하는 조성물의 용도 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9707683A (es) * | 1995-04-07 | 1997-12-31 | Novartis Ag | Composiciones de combinacion que contienen benazepril o benazeprilat y valsartan. |
| EP2514756B1 (en) | 2003-08-01 | 2014-12-17 | Mitsubishi Tanabe Pharma Corporation | Novel compounds having inhibitory activity against sodium-dependant glucose transporter |
| UY30730A1 (es) * | 2006-12-04 | 2008-07-03 | Mitsubishi Tanabe Pharma Corp | Forma cristalina del hemihidrato de 1-(b (beta)-d-glucopiranosil) -4-metil-3-[5-(4-fluorofenil) -2-tienilmetil]benceno |
| WO2008113095A1 (en) * | 2007-03-20 | 2008-09-25 | Fibrotech Therapeutics Pty Ltd | Compositions and therapies comprising tranilast compounds and angiotensin-converting enzyme (ace) inhibitors and/or angiotensin receptor blockers (arb) |
| UY32030A (es) * | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| KR20110103987A (ko) * | 2008-12-01 | 2011-09-21 | 인베이스크 테라퓨틱, 인크. | 레닌-안지오텐신 알도스테론계 억제제 및 리포산 화합물을 포함하는 조성물, 및 레닌-안지오텐신 알도스테론계 관련 질환의 치료를 위한 이의 용도 |
| CA2756779C (en) * | 2009-03-26 | 2019-10-29 | Ajay Gupta | Compositions and methods for treatment of renal disease |
| JP2013523681A (ja) * | 2010-03-30 | 2013-06-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｓｇｌｔ２インヒビター及びｐｐａｒ−ガンマアゴニストを含む医薬組成物並びにその使用 |
| KR101890959B1 (ko) * | 2010-11-04 | 2018-08-22 | 알비레오 에이비 | 간질환 치료를 위한 ｉｂａｔ 억제제 |
| US8946224B2 (en) * | 2010-11-11 | 2015-02-03 | Redx Pharma Limited | Substituted [1,2,4]triazolo[4,3-A]pyrazines for medicaments and pharmaceutical compositions |
| US9034883B2 (en) * | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
-
2015
- 2015-01-30 CA CA2938406A patent/CA2938406A1/en not_active Abandoned
- 2015-01-30 MX MX2016010011A patent/MX2016010011A/es unknown
- 2015-01-30 EA EA201691555A patent/EA201691555A1/ru unknown
- 2015-01-30 KR KR1020167023439A patent/KR20160107344A/ko not_active Ceased
- 2015-01-30 CN CN202110463431.1A patent/CN113144204A/zh active Pending
- 2015-01-30 US US15/112,786 patent/US20160339047A1/en not_active Abandoned
- 2015-01-30 JP JP2016549388A patent/JP2017504649A/ja not_active Withdrawn
- 2015-01-30 EP EP15705743.1A patent/EP3099328A1/en not_active Withdrawn
- 2015-01-30 AU AU2015210898A patent/AU2015210898A1/en not_active Abandoned
- 2015-01-30 CN CN202110463410.XA patent/CN113082021A/zh active Pending
- 2015-01-30 CN CN201580006608.8A patent/CN105939728A/zh active Pending
- 2015-01-30 WO PCT/US2015/013644 patent/WO2015116880A1/en not_active Ceased
-
2016
- 2016-07-14 IL IL246779A patent/IL246779A0/en unknown
-
2018
- 2018-07-20 US US16/040,580 patent/US20180344756A1/en not_active Abandoned
-
2020
- 2020-01-16 JP JP2020005106A patent/JP2020090511A/ja active Pending
- 2020-12-02 AU AU2020281039A patent/AU2020281039A1/en not_active Abandoned
-
2021
- 2021-01-05 US US17/141,248 patent/US20210121492A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3099328A1 (en) | 2016-12-07 |
| CN113144204A (zh) | 2021-07-23 |
| WO2015116880A1 (en) | 2015-08-06 |
| CN113082021A (zh) | 2021-07-09 |
| CA2938406A1 (en) | 2015-08-06 |
| MX2016010011A (es) | 2016-10-07 |
| JP2020090511A (ja) | 2020-06-11 |
| AU2020281039A1 (en) | 2021-01-07 |
| CN105939728A (zh) | 2016-09-14 |
| KR20160107344A (ko) | 2016-09-13 |
| JP2017504649A (ja) | 2017-02-09 |
| IL246779A0 (en) | 2016-08-31 |
| US20210121492A1 (en) | 2021-04-29 |
| AU2015210898A1 (en) | 2016-07-28 |
| US20180344756A1 (en) | 2018-12-06 |
| US20160339047A1 (en) | 2016-11-24 |
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