EA201691074A1 - Синтез энт-прогестерона и его промежуточных соединений - Google Patents
Синтез энт-прогестерона и его промежуточных соединенийInfo
- Publication number
- EA201691074A1 EA201691074A1 EA201691074A EA201691074A EA201691074A1 EA 201691074 A1 EA201691074 A1 EA 201691074A1 EA 201691074 A EA201691074 A EA 201691074A EA 201691074 A EA201691074 A EA 201691074A EA 201691074 A1 EA201691074 A1 EA 201691074A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- progesterone
- ent
- synthesis
- intermediate compounds
- racemate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
- C07J15/005—Retrosteroids (9 beta 10 alfa)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
- C07J75/005—Preparation of steroids by cyclization of non-steroid compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
Настоящее изобретение относится к способу получения энт-прогестерона формулыЭнт-прогестерон обладает, по меньшей мере, такой же эффективностью, как и природный прогестерон, в отношении уменьшения клеточной смерти, отека головного мозга и воспаления, при этом антиоксидантная активность энантиомера в три раза превышает антиоксидантную активность рацемата.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361919420P | 2013-12-20 | 2013-12-20 | |
| PCT/US2014/070879 WO2015095339A1 (en) | 2013-12-20 | 2014-12-17 | Synthesis of ent-progesterone and intermediates thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201691074A1 true EA201691074A1 (ru) | 2017-02-28 |
Family
ID=53399300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201691074A EA201691074A1 (ru) | 2013-12-20 | 2014-12-17 | Синтез энт-прогестерона и его промежуточных соединений |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20150175650A1 (ru) |
| EP (1) | EP3083656A1 (ru) |
| JP (1) | JP2017502031A (ru) |
| CN (1) | CN105980396B (ru) |
| AR (1) | AR098879A1 (ru) |
| AU (1) | AU2014364850A1 (ru) |
| BR (1) | BR112016014000A2 (ru) |
| CA (1) | CA2934466A1 (ru) |
| EA (1) | EA201691074A1 (ru) |
| IL (1) | IL246258A0 (ru) |
| MA (1) | MA39126B1 (ru) |
| MX (1) | MX2016008167A (ru) |
| PH (1) | PH12016501201A1 (ru) |
| SG (1) | SG11201604982XA (ru) |
| TN (1) | TN2016000252A1 (ru) |
| TW (1) | TW201538519A (ru) |
| UY (1) | UY35909A (ru) |
| WO (1) | WO2015095339A1 (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017100988A (ja) * | 2015-12-01 | 2017-06-08 | アサヒグループホールディングス株式会社 | 光学活性なヒドロキシ脂肪酸の製造方法 |
| IT201700004904A1 (it) * | 2017-01-18 | 2018-07-18 | Ind Chimica Srl | PROCESSO PER LA PREPARAZIONE DI 9β,10α-PROGESTERONE (RETROPROGESTERONE) |
| JP2022543244A (ja) * | 2019-08-02 | 2022-10-11 | エンターイン、 インコーポレイテッド | ヒトスクアラミン誘導体、それを含む関連組成物、およびそれを用いた方法 |
| CA3149479A1 (en) * | 2019-08-02 | 2021-02-11 | Enterin, Inc. | Human aminosterol ent-03 compounds, related compositions comprising the same, and methods of using the same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9527881B2 (en) * | 2008-02-26 | 2016-12-27 | Emory University | Steroid analogues for neuroprotection |
| US20110306579A1 (en) * | 2009-01-30 | 2011-12-15 | Emory University | Methods of neuroprotection using neuroprotective steroids and a vitamin d |
| MX2014004202A (es) * | 2011-10-07 | 2015-03-05 | Univ Florida State Res Found | Uso post-agudo y profiláctico de progesterona para mejores resultados asociados con concusión. |
-
2014
- 2014-12-17 MX MX2016008167A patent/MX2016008167A/es unknown
- 2014-12-17 TN TN2016000252A patent/TN2016000252A1/en unknown
- 2014-12-17 MA MA39126A patent/MA39126B1/fr unknown
- 2014-12-17 CN CN201480072282.4A patent/CN105980396B/zh not_active Expired - Fee Related
- 2014-12-17 SG SG11201604982XA patent/SG11201604982XA/en unknown
- 2014-12-17 CA CA2934466A patent/CA2934466A1/en not_active Abandoned
- 2014-12-17 AU AU2014364850A patent/AU2014364850A1/en not_active Abandoned
- 2014-12-17 EP EP14871117.9A patent/EP3083656A1/en not_active Withdrawn
- 2014-12-17 EA EA201691074A patent/EA201691074A1/ru unknown
- 2014-12-17 JP JP2016541444A patent/JP2017502031A/ja active Pending
- 2014-12-17 BR BR112016014000A patent/BR112016014000A2/pt not_active IP Right Cessation
- 2014-12-17 US US14/573,656 patent/US20150175650A1/en not_active Abandoned
- 2014-12-17 WO PCT/US2014/070879 patent/WO2015095339A1/en active Application Filing
- 2014-12-19 AR ARP140104814A patent/AR098879A1/es unknown
- 2014-12-19 TW TW103144457A patent/TW201538519A/zh unknown
- 2014-12-19 UY UY0001035909A patent/UY35909A/es not_active Application Discontinuation
-
2016
- 2016-06-16 IL IL246258A patent/IL246258A0/en unknown
- 2016-06-20 PH PH12016501201A patent/PH12016501201A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW201538519A (zh) | 2015-10-16 |
| WO2015095339A1 (en) | 2015-06-25 |
| IL246258A0 (en) | 2016-08-02 |
| MA39126A2 (fr) | 2018-08-31 |
| MX2016008167A (es) | 2017-04-27 |
| JP2017502031A (ja) | 2017-01-19 |
| TN2016000252A1 (en) | 2017-10-06 |
| BR112016014000A2 (pt) | 2017-08-08 |
| CN105980396A (zh) | 2016-09-28 |
| US20150175650A1 (en) | 2015-06-25 |
| MA39126B1 (fr) | 2020-03-31 |
| CN105980396B (zh) | 2019-03-22 |
| CA2934466A1 (en) | 2015-06-25 |
| AU2014364850A1 (en) | 2016-07-07 |
| EP3083656A1 (en) | 2016-10-26 |
| MA39126A3 (fr) | 2019-04-30 |
| SG11201604982XA (en) | 2016-07-28 |
| AR098879A1 (es) | 2016-06-22 |
| PH12016501201A1 (en) | 2016-08-15 |
| UY35909A (es) | 2015-07-31 |
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