EA201690838A1 - Способ снижения воспалительной активности трансплантата стволовых клеток и его применение - Google Patents

Способ снижения воспалительной активности трансплантата стволовых клеток и его применение

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Publication number
EA201690838A1
EA201690838A1 EA201690838A EA201690838A EA201690838A1 EA 201690838 A1 EA201690838 A1 EA 201690838A1 EA 201690838 A EA201690838 A EA 201690838A EA 201690838 A EA201690838 A EA 201690838A EA 201690838 A1 EA201690838 A1 EA 201690838A1
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Eurasian Patent Office
Prior art keywords
stem cell
inflammatory activity
reducing
cell transplantation
application
Prior art date
Application number
EA201690838A
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English (en)
Other versions
EA035338B1 (ru
Inventor
Йоханнес Петрус Йозеф Мария Мюнтер Де
Эккехард Ланг
Эрик Харлес Мария Йосеф Волтерс
Петрус Теодорус Хан Де
Original Assignee
Нёропласт Бехер Б.В.
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Application filed by Нёропласт Бехер Б.В. filed Critical Нёропласт Бехер Б.В.
Publication of EA201690838A1 publication Critical patent/EA201690838A1/ru
Publication of EA035338B1 publication Critical patent/EA035338B1/ru

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Abstract

Данное изобретение относится к области клеточной терапии, конкретнее - к терапии с трансплантацией стволовых клеток. Предлагаются способы и композиции для повышения эффективности терапии с трансплантацией стволовых клеток путем снижения воспалительной активности трансплантата стволовых клеток. В частности, предлагается способ получения трансплантата стволовых клеток с пониженной воспалительной активностью, включающий этап суспендирования композиции, содержащей стволовые клетки, в плазме, из которой удален фибриноген, и/или в плазме, из которой удалены фибриноген и С-реактивный белок.
EA201690838A 2013-10-24 2014-10-24 Композиция гемопоэтических стволовых клеток с пониженной воспалительной активностью, ее получение и применение EA035338B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13190120 2013-10-24
PCT/EP2014/072911 WO2015059300A1 (en) 2013-10-24 2014-10-24 Method for reducing the inflammatory activity of a stem cell transplant and use thereof

Publications (2)

Publication Number Publication Date
EA201690838A1 true EA201690838A1 (ru) 2016-08-31
EA035338B1 EA035338B1 (ru) 2020-05-29

Family

ID=49474298

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201690838A EA035338B1 (ru) 2013-10-24 2014-10-24 Композиция гемопоэтических стволовых клеток с пониженной воспалительной активностью, ее получение и применение

Country Status (6)

Country Link
US (2) US9839653B2 (ru)
EP (1) EP3060653B1 (ru)
DK (1) DK3060653T3 (ru)
EA (1) EA035338B1 (ru)
ES (1) ES2729640T3 (ru)
WO (1) WO2015059300A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3060653B1 (en) 2013-10-24 2019-03-27 Neuroplast Beheer B.V. Method for reducing the inflammatory activity of a stem cell transplant and use thereof
WO2016178914A1 (en) * 2015-05-01 2016-11-10 Cesca Therapeutics, Inc. Intramuscular adaminstration of autologous bone marrw for treatment

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3875456T3 (de) 1987-11-09 1998-06-10 Becton Dickinson Co Verfahren zur Analyse hämatopoietischer Zellen in einer Probe.
US5087570A (en) 1988-05-10 1992-02-11 Weissman Irving L Homogeneous mammalian hematopoietic stem cell composition
GB2343679A (en) 1998-11-16 2000-05-17 Alison Miriam Davies Autologous transplantation and method for making cells dormant
US6645727B2 (en) 2000-05-26 2003-11-11 Stemcell Technologies Inc. Antibody compositions for preparing enriched mesenchymal progenitor preparations
US20030032185A1 (en) 2001-05-03 2003-02-13 Sharkis Saul J. Method of making a homogeneous preparation of hematopoietic stem cells
CZ301148B6 (cs) 2006-01-25 2009-11-18 Univerzita Karlova V Praze Zpusob pestování lidských mezenchymových kmenových bunek, zejména pro lécbu nehojících se fraktur, a bioreaktor k provádení tohoto zpusobu
EP1852500A1 (en) 2006-05-02 2007-11-07 Stemwell LLC Stem cells derived from bone marrow for tissue regeneration
WO2008036374A2 (en) 2006-09-21 2008-03-27 Medistem Laboratories, Inc. Allogeneic stem cell transplants in non-conditioned recipients
EP3060653B1 (en) 2013-10-24 2019-03-27 Neuroplast Beheer B.V. Method for reducing the inflammatory activity of a stem cell transplant and use thereof

Also Published As

Publication number Publication date
EA035338B1 (ru) 2020-05-29
DK3060653T3 (da) 2019-06-11
EP3060653A1 (en) 2016-08-31
US10406181B2 (en) 2019-09-10
ES2729640T3 (es) 2019-11-05
WO2015059300A1 (en) 2015-04-30
US20180042967A1 (en) 2018-02-15
US20160228468A1 (en) 2016-08-11
EP3060653B1 (en) 2019-03-27
US9839653B2 (en) 2017-12-12

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