EA201690622A1 - Соль дигидрофосфат тенофовира дизопроксила - Google Patents
Соль дигидрофосфат тенофовира дизопроксилаInfo
- Publication number
- EA201690622A1 EA201690622A1 EA201690622A EA201690622A EA201690622A1 EA 201690622 A1 EA201690622 A1 EA 201690622A1 EA 201690622 A EA201690622 A EA 201690622A EA 201690622 A EA201690622 A EA 201690622A EA 201690622 A1 EA201690622 A1 EA 201690622A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- tenofovir
- dihydrophosphat
- denoproxyl
- salt
- dihydrophosphate
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title 1
- 229960004556 tenofovir Drugs 0.000 title 1
- SGOIRFVFHAKUTI-ZCFIWIBFSA-N tenofovir (anhydrous) Chemical compound N1=CN=C2N(C[C@@H](C)OCP(O)(O)=O)C=NC2=C1N SGOIRFVFHAKUTI-ZCFIWIBFSA-N 0.000 title 1
- 238000000034 method Methods 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- JFVZFKDSXNQEJW-CQSZACIVSA-N tenofovir disoproxil Chemical compound N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N JFVZFKDSXNQEJW-CQSZACIVSA-N 0.000 abstract 1
- 229960001355 tenofovir disoproxil Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13004844.0A EP2860184B1 (en) | 2013-10-09 | 2013-10-09 | Dihydrogenphosphate salt of Tenofovir disoproxil |
| PCT/EP2014/002562 WO2015051875A1 (en) | 2013-10-09 | 2014-09-22 | Dihydrogenphosphate salt of tenofovir disoproxil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201690622A1 true EA201690622A1 (ru) | 2016-08-31 |
Family
ID=49354420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201690622A EA201690622A1 (ru) | 2013-10-09 | 2014-09-22 | Соль дигидрофосфат тенофовира дизопроксила |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP2860184B1 (enExample) |
| JP (1) | JP2016534047A (enExample) |
| KR (1) | KR20160067843A (enExample) |
| CN (1) | CN105612167A (enExample) |
| BR (1) | BR112016007617A2 (enExample) |
| EA (1) | EA201690622A1 (enExample) |
| IL (1) | IL244848A0 (enExample) |
| MX (1) | MX2016003757A (enExample) |
| PT (1) | PT2860184T (enExample) |
| WO (1) | WO2015051875A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160003532A (ko) * | 2014-07-01 | 2016-01-11 | 한미약품 주식회사 | 테노포비어 디소프록실 인산염과, 비금속염 붕해제 및 비금속염 활택제를 포함하는 약학 조성물 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998004569A1 (en) | 1996-07-26 | 1998-02-05 | Gilead Sciences, Inc. | Nucleotide analogs |
| PT915894E (pt) | 1996-07-26 | 2003-10-31 | Gilead Sciences Inc | Analogos de nucleotidos |
| US5935946A (en) | 1997-07-25 | 1999-08-10 | Gilead Sciences, Inc. | Nucleotide analog composition and synthesis method |
| ATE305009T1 (de) | 1997-07-25 | 2005-10-15 | Gilead Sciences Inc | Nukleotid-analog zusamensetzung und synthese verfahren |
| WO2007013086A1 (en) | 2005-07-26 | 2007-02-01 | Hetero Drugs Limited | Novel polymorphs of tenofovir disoproxil fumarate |
| WO2008007392A2 (en) | 2006-07-12 | 2008-01-17 | Matrix Laboratories Limited | Process for the preparation of tenofovir |
| WO2008140302A1 (en) | 2007-05-14 | 2008-11-20 | Ultimorphix Technologies B.V. | Polymorphic forms of tenofovir disoproxil fumarate |
| WO2008143500A1 (en) | 2007-05-22 | 2008-11-27 | Ultimorphix Technologies B.V. | Tenofovir disoproxil hemi-fumaric acid co-crystal |
| WO2009064174A1 (en) | 2007-11-14 | 2009-05-22 | Ultimorphix Technologies B.V. | Polymorphic form of tenofovir disoproxil fumarate, method for its preparation and use |
| EP2220098A2 (en) * | 2007-12-12 | 2010-08-25 | Ultimorphix Technologies B.v. | Solid forms of tenofovir disoproxil |
| NZ588796A (en) * | 2008-04-25 | 2012-07-27 | Cipla Ltd | Crystalline form of tenofovir disoproxil and a process for its preparation |
| WO2010142761A1 (en) | 2009-06-10 | 2010-12-16 | Ultimorphix Technologies B.V. | The succinate of tenofovir disoproxil |
| CN101781334B (zh) * | 2010-03-04 | 2012-11-28 | 福建广生堂药业股份有限公司 | 替诺福韦酯的盐化合物，其制备方法和药物应用 |
| CN103282369A (zh) * | 2011-04-08 | 2013-09-04 | 劳乐斯实验室私营有限公司 | 抗逆转录病毒化合物与抗氧化酸的固体形式、其制备方法以及其药物组合物 |
| WO2013132314A1 (en) * | 2012-03-05 | 2013-09-12 | Laurus Labs Private Limited | Tenofovir phosphate, processes for the preparation and pharmaceutical composition thereof |
-
2013
- 2013-10-09 PT PT13004844T patent/PT2860184T/pt unknown
- 2013-10-09 EP EP13004844.0A patent/EP2860184B1/en active Active
-
2014
- 2014-09-22 MX MX2016003757A patent/MX2016003757A/es unknown
- 2014-09-22 EA EA201690622A patent/EA201690622A1/ru unknown
- 2014-09-22 KR KR1020167007764A patent/KR20160067843A/ko not_active Withdrawn
- 2014-09-22 BR BR112016007617A patent/BR112016007617A2/pt not_active IP Right Cessation
- 2014-09-22 CN CN201480055828.5A patent/CN105612167A/zh active Pending
- 2014-09-22 JP JP2016522025A patent/JP2016534047A/ja not_active Ceased
- 2014-09-22 WO PCT/EP2014/002562 patent/WO2015051875A1/en not_active Ceased
-
2016
- 2016-03-31 IL IL244848A patent/IL244848A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2016003757A (es) | 2016-07-08 |
| EP2860184B1 (en) | 2018-08-29 |
| JP2016534047A (ja) | 2016-11-04 |
| KR20160067843A (ko) | 2016-06-14 |
| IL244848A0 (en) | 2016-05-31 |
| PT2860184T (pt) | 2018-11-20 |
| WO2015051875A1 (en) | 2015-04-16 |
| EP2860184A1 (en) | 2015-04-15 |
| CN105612167A (zh) | 2016-05-25 |
| BR112016007617A2 (pt) | 2017-08-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1120635T1 (el) | Βενζαμιδια αμινοετεροαρυλιου ως αναστολεις κινασης | |
| MY184733A (en) | Pyrimidine fgfr4 inhibitors | |
| WO2015054642A3 (en) | Use of cbp/ep300 bromodomain inhibitors for cancer immunotherapy | |
| EP3027192A4 (en) | Methods for the treatment of solid tumors | |
| DK3030255T3 (da) | Novel immunotherapy against several tumors, such as lung cancer, including nsclc | |
| WO2015091853A3 (en) | Human anti-cd40 human antibodies | |
| WO2014152157A8 (en) | Methods and compositions for the generation and use of conformation-specific antibodies | |
| MY189912A (en) | Substituted xanthines and methods of use thereof | |
| PH12015502031A1 (en) | Tetrahydropyrrolothiazine compounds | |
| EA201390074A1 (ru) | 5-хлор-4-гидрокси-1-метил-2-оксо-n-фенил-1,2-дигидрохинолин-3-карбоксамид, его соли и применения | |
| SG11201600048VA (en) | Novel fused pyrimidine compound or salt thereof | |
| MX2015014298A (es) | Compuestos de dihidropirido pirimidina como inhibidores de autotaxina. | |
| MX2023006416A (es) | Anticuerpos, usos y metodos. | |
| EP4606784A3 (en) | Co-crystals, salts and solid forms of tenofovir alafenamide | |
| MX381000B (es) | Cristales de compuesto azabicíclico. | |
| MX2015011837A (es) | Co-cristale de pirimetanil y tetracarboximida de ditiina seleccionada. | |
| CL2015002358A1 (es) | Compuestos bicíclicos. | |
| IN2013MU03862A (enExample) | ||
| MY160902A (en) | Process for the preparation of the L-arginine salt of perindopril | |
| PH12015502122A1 (en) | Sovaprevir polymorphs and methods of manufacturing thereof | |
| MX2016001641A (es) | Ciclobutilcarboxamidas como nematicidas. | |
| EP3030268A4 (en) | Combination of ifn-gamma with anti-erbb antibody for the treatment of cancers | |
| MX2015016332A (es) | Inhibidores de alk biciclicos fusionados. | |
| EA201690263A1 (ru) | Улучшенные способы получения перампанеля | |
| EA201690294A1 (ru) | Новые соединения и их применение для получения tau-визуализирующих агентов и tau-визуализирующих составов |