EA201690170A1 - Композиции и способы для лечения инсульта - Google Patents
Композиции и способы для лечения инсультаInfo
- Publication number
- EA201690170A1 EA201690170A1 EA201690170A EA201690170A EA201690170A1 EA 201690170 A1 EA201690170 A1 EA 201690170A1 EA 201690170 A EA201690170 A EA 201690170A EA 201690170 A EA201690170 A EA 201690170A EA 201690170 A1 EA201690170 A1 EA 201690170A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- stroke
- ischemic stroke
- methods
- treatment
- compositions
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
Изобретение относится, inter alia, к способам лечения инсульта, например ишемического инсульта, например острого ишемического инсульта, и способам уменьшения размера инфаркта и/или других неврологических нарушений, связанных с инсультом, например ишемическим инсультом, например острым ишемическим инсультом, в которых применяется антагонист VLA-4, такой как натализумаб. Было обнаружено, что антагонисты VLA-4, такие как натализумаб, могут эффективно уменьшать размер инфаркта и других неврологических нарушений при инсульте, например ишемическом инсульте, например остром ишемическом инсульте, например, при введении в течение определенного периода после начала инсульта. Также в данном документе раскрыты изделия и наборы для лечения инсульта, например ишемического инсульта, например острого ишемического инсульта.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361843125P | 2013-07-05 | 2013-07-05 | |
PCT/US2014/045457 WO2015003156A1 (en) | 2013-07-05 | 2014-07-03 | Compositions and methods for treatment of stroke |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201690170A1 true EA201690170A1 (ru) | 2016-05-31 |
Family
ID=52144219
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201690170A EA201690170A1 (ru) | 2013-07-05 | 2014-07-03 | Композиции и способы для лечения инсульта |
Country Status (13)
Country | Link |
---|---|
US (1) | US20160152709A1 (ru) |
EP (1) | EP3016981A4 (ru) |
JP (1) | JP2016523931A (ru) |
KR (1) | KR20160030200A (ru) |
CN (1) | CN105658667A (ru) |
AU (1) | AU2014285086A1 (ru) |
CA (1) | CA2916028A1 (ru) |
EA (1) | EA201690170A1 (ru) |
HK (1) | HK1217715A1 (ru) |
IL (1) | IL243265A0 (ru) |
MX (1) | MX2015017467A (ru) |
WO (1) | WO2015003156A1 (ru) |
ZA (1) | ZA201509360B (ru) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2034830T3 (pl) * | 2006-05-25 | 2015-04-30 | Biogen Ma Inc | Przeciwciało anty-VLA-1 do leczenia udaru |
WO2017015544A1 (en) * | 2015-07-23 | 2017-01-26 | Biogen Ma Inc. | Compositions and methods for treatment of stroke and other cns disorders |
WO2018140510A1 (en) * | 2017-01-25 | 2018-08-02 | Biogen Ma Inc. | Compositions and methods for treatment of stroke and other cns disorders |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2258400A3 (en) * | 2004-07-08 | 2011-08-10 | Elan Pharmaceuticals, Inc. | Multivalent VLA-4 antagonists comprising polymer moieties |
EP1827491A4 (en) * | 2004-11-19 | 2010-07-14 | Biogen Idec Inc | TREATMENT OF MULTIPLE SCLEROSIS |
PL2034830T3 (pl) * | 2006-05-25 | 2015-04-30 | Biogen Ma Inc | Przeciwciało anty-VLA-1 do leczenia udaru |
US8771689B2 (en) * | 2006-12-11 | 2014-07-08 | The Board Of Trustees Of The Leland Stanford Junior University | Alpha B-crystallin as a therapy for ischemia or inflammation |
EP2050462A1 (en) * | 2007-10-18 | 2009-04-22 | PAION Deutschland GmbH | Improved treatment of stroke patients |
PT3202789T (pt) * | 2010-04-16 | 2020-06-16 | Biogen Ma Inc | Anticorpos anti-vla-4 |
AU2012325013A1 (en) * | 2011-10-17 | 2014-03-27 | Westfaelische Wilhelms-Universitaet Muenster | Methods of risk assessment of PML and related apparatus |
-
2014
- 2014-07-03 WO PCT/US2014/045457 patent/WO2015003156A1/en active Application Filing
- 2014-07-03 AU AU2014285086A patent/AU2014285086A1/en not_active Abandoned
- 2014-07-03 CN CN201480045749.6A patent/CN105658667A/zh active Pending
- 2014-07-03 EP EP14820267.4A patent/EP3016981A4/en not_active Withdrawn
- 2014-07-03 MX MX2015017467A patent/MX2015017467A/es unknown
- 2014-07-03 CA CA2916028A patent/CA2916028A1/en not_active Abandoned
- 2014-07-03 US US14/902,911 patent/US20160152709A1/en not_active Abandoned
- 2014-07-03 KR KR1020167002242A patent/KR20160030200A/ko not_active Application Discontinuation
- 2014-07-03 EA EA201690170A patent/EA201690170A1/ru unknown
- 2014-07-03 JP JP2016524379A patent/JP2016523931A/ja not_active Withdrawn
-
2015
- 2015-12-21 IL IL243265A patent/IL243265A0/en unknown
- 2015-12-23 ZA ZA2015/09360A patent/ZA201509360B/en unknown
-
2016
- 2016-05-17 HK HK16105676.2A patent/HK1217715A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CN105658667A (zh) | 2016-06-08 |
CA2916028A1 (en) | 2015-01-08 |
IL243265A0 (en) | 2016-03-31 |
EP3016981A1 (en) | 2016-05-11 |
WO2015003156A1 (en) | 2015-01-08 |
HK1217715A1 (zh) | 2017-01-20 |
ZA201509360B (en) | 2018-07-25 |
JP2016523931A (ja) | 2016-08-12 |
MX2015017467A (es) | 2016-04-25 |
KR20160030200A (ko) | 2016-03-16 |
AU2014285086A1 (en) | 2016-01-21 |
US20160152709A1 (en) | 2016-06-02 |
EP3016981A4 (en) | 2017-05-31 |
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