EA201592120A1 - Состав на основе наночастиц, содержащий антагонист trpa1 - Google Patents
Состав на основе наночастиц, содержащий антагонист trpa1Info
- Publication number
- EA201592120A1 EA201592120A1 EA201592120A EA201592120A EA201592120A1 EA 201592120 A1 EA201592120 A1 EA 201592120A1 EA 201592120 A EA201592120 A EA 201592120A EA 201592120 A EA201592120 A EA 201592120A EA 201592120 A1 EA201592120 A1 EA 201592120A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- trpa1
- composition based
- antagonist
- nanoparticles containing
- nanoparticles
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Nanotechnology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Настоящее изобретение относится к составу на основе наночастиц, который содержит антагонист анкирин-1 рецептора ионного канала с транзиторным рецепторным потенциалом ("TRPA1"). Конкретно, данное изобретение относится к составу на основе наночастиц, который содержит производное тиенопиримидиндиона в качестве антагониста TRPA1 и поверхностный стабилизатор, к способу получения такого состава и к его применению при лечении респираторного нарушения или боли у субъекта.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2090MU2013 | 2013-06-20 | ||
PCT/IB2014/062462 WO2014203210A1 (en) | 2013-06-20 | 2014-06-20 | Nanoparticulate formulation comprising a trpa1 antagonist |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201592120A1 true EA201592120A1 (ru) | 2016-04-29 |
Family
ID=51136536
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201592120A EA201592120A1 (ru) | 2013-06-20 | 2014-06-20 | Состав на основе наночастиц, содержащий антагонист trpa1 |
Country Status (13)
Country | Link |
---|---|
US (1) | US10603277B2 (ru) |
EP (1) | EP3010489A1 (ru) |
JP (1) | JP2016522251A (ru) |
CN (1) | CN105307642A (ru) |
AP (1) | AP2015008919A0 (ru) |
AU (1) | AU2014282762B2 (ru) |
BR (1) | BR112015030341A2 (ru) |
CA (1) | CA2912578A1 (ru) |
EA (1) | EA201592120A1 (ru) |
HK (1) | HK1221161A1 (ru) |
MX (1) | MX2015016024A (ru) |
PH (1) | PH12015502820A1 (ru) |
WO (1) | WO2014203210A1 (ru) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016042501A1 (en) * | 2014-09-16 | 2016-03-24 | Glenmark Pharmaceuticals S.A. | Trpa1 antagonist for the treatment of pain associated to diabetic neuropathic pain |
PL3568122T3 (pl) * | 2017-01-10 | 2024-03-18 | Dukebox Sp. Z O.O. | Sposób wytwarzania zawiesiny nanocząsteczek soli potasowej albo soli magnezowej |
HUE056959T2 (hu) * | 2018-09-11 | 2022-04-28 | Lead Biotherapeutics Ltd | Mukoadheziv diszperziós nanorészecske rendszer és eljárás annak elõállítására |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
IT1298575B1 (it) | 1998-02-06 | 2000-01-12 | Vectorpharma Int | Composizioni farmaceutiche in forma di nanoparticelle comprendenti sostanze lipidiche e sostanze antifiliche e relativo processo di |
US8771740B2 (en) | 1999-12-20 | 2014-07-08 | Nicholas J. Kerkhof | Process for producing nanoparticles by spray drying |
US7998507B2 (en) | 2000-09-21 | 2011-08-16 | Elan Pharma International Ltd. | Nanoparticulate compositions of mitogen-activated protein (MAP) kinase inhibitors |
UA76810C2 (ru) | 2001-12-10 | 2006-09-15 | Мерк Енд Ко., Інк. | Фармацевтическая композиция антагониста рецептора тахикинина в форме наночастиц |
JP2008531721A (ja) * | 2005-03-03 | 2008-08-14 | エラン・ファルマ・インターナショナル・リミテッド | 複素環式アミド誘導体のナノ粒子状組成物 |
EP1863450A1 (en) * | 2005-03-16 | 2007-12-12 | Elan Pharma International Limited | Nanoparticulate leukotriene receptor antagonist/corticosteroid formulations |
DK2411397T3 (da) | 2009-03-23 | 2013-08-05 | Glenmark Pharmaceuticals Sa | Isothiazol-pyrimidindionderivater som modulatorer af TRPA1 |
PL2411395T3 (pl) * | 2009-03-23 | 2013-10-31 | Glenmark Pharmaceuticals Sa | Pochodne furopirymidynodionu jako modulatory TRPA1 |
WO2010141805A1 (en) | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Heterocyclic amides as modulators of trpa1 |
JP2013507364A (ja) | 2009-10-07 | 2013-03-04 | メルク・シャープ・エンド・ドーム・コーポレイション | 新規なtrpa1アンタゴニスト |
WO2012176105A1 (en) * | 2011-06-22 | 2012-12-27 | Glenmark Pharmaceuticals Sa | Pharmaceutical composition comprising a trpa1 antagonist and a leukotriene receptor antagonist |
IN2014MN02467A (ru) | 2012-06-08 | 2015-07-10 | Glenmark Pharmaceuticals Sa |
-
2014
- 2014-06-20 BR BR112015030341A patent/BR112015030341A2/pt not_active IP Right Cessation
- 2014-06-20 CA CA2912578A patent/CA2912578A1/en not_active Abandoned
- 2014-06-20 EA EA201592120A patent/EA201592120A1/ru unknown
- 2014-06-20 WO PCT/IB2014/062462 patent/WO2014203210A1/en active Application Filing
- 2014-06-20 CN CN201480035009.4A patent/CN105307642A/zh active Pending
- 2014-06-20 US US14/310,447 patent/US10603277B2/en active Active
- 2014-06-20 AP AP2015008919A patent/AP2015008919A0/xx unknown
- 2014-06-20 EP EP14736460.8A patent/EP3010489A1/en not_active Withdrawn
- 2014-06-20 MX MX2015016024A patent/MX2015016024A/es unknown
- 2014-06-20 AU AU2014282762A patent/AU2014282762B2/en active Active
- 2014-06-20 JP JP2016520798A patent/JP2016522251A/ja active Pending
-
2015
- 2015-12-18 PH PH12015502820A patent/PH12015502820A1/en unknown
-
2016
- 2016-08-04 HK HK16109317.9A patent/HK1221161A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
AU2014282762B2 (en) | 2016-11-10 |
US20140377358A1 (en) | 2014-12-25 |
MX2015016024A (es) | 2016-04-04 |
JP2016522251A (ja) | 2016-07-28 |
AU2014282762A1 (en) | 2015-11-26 |
BR112015030341A2 (pt) | 2017-07-25 |
AP2015008919A0 (en) | 2015-12-31 |
WO2014203210A1 (en) | 2014-12-24 |
CN105307642A (zh) | 2016-02-03 |
PH12015502820A1 (en) | 2016-03-21 |
CA2912578A1 (en) | 2014-12-24 |
EP3010489A1 (en) | 2016-04-27 |
HK1221161A1 (zh) | 2017-05-26 |
US10603277B2 (en) | 2020-03-31 |
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