EA201590417A1 - Новые 4,6-дизамещенные аминопиримидиновые производные - Google Patents

Новые 4,6-дизамещенные аминопиримидиновые производные

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Publication number
EA201590417A1
EA201590417A1 EA201590417A EA201590417A EA201590417A1 EA 201590417 A1 EA201590417 A1 EA 201590417A1 EA 201590417 A EA201590417 A EA 201590417A EA 201590417 A EA201590417 A EA 201590417A EA 201590417 A1 EA201590417 A1 EA 201590417A1
Authority
EA
Eurasian Patent Office
Prior art keywords
designed
new
aminopyrimidine derivatives
derivatives
aminopyrimidine
Prior art date
Application number
EA201590417A
Other languages
English (en)
Other versions
EA029278B1 (ru
Inventor
Франко Лори
Джеймс Шафулеа
Давиде Де Форни
Антонио Солинас
Зольтан Варга
Зольтан Грефф (умер)
Ласло Орфи
Дьердь Кери
Original Assignee
Виростэтикс Срл
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Виростэтикс Срл filed Critical Виростэтикс Срл
Publication of EA201590417A1 publication Critical patent/EA201590417A1/ru
Publication of EA029278B1 publication Critical patent/EA029278B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Определенные 4,6-дизамещенные аминопиримидиновые производные, имеющие как ароматические, так и галогеновые заместители.
EA201590417A 2012-08-23 2013-08-23 Новые 4,6-дизамещенные аминопиримидиновые производные EA029278B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261692641P 2012-08-23 2012-08-23
PCT/US2013/056347 WO2014031937A1 (en) 2012-08-23 2013-08-23 Novel 4,6-disubstituted aminopyrimidine derivatives

Publications (2)

Publication Number Publication Date
EA201590417A1 true EA201590417A1 (ru) 2015-07-30
EA029278B1 EA029278B1 (ru) 2018-03-30

Family

ID=50148518

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590417A EA029278B1 (ru) 2012-08-23 2013-08-23 Новые 4,6-дизамещенные аминопиримидиновые производные

Country Status (26)

Country Link
US (2) US9617225B2 (ru)
EP (1) EP2887943B1 (ru)
JP (2) JP6639231B2 (ru)
KR (1) KR102209229B1 (ru)
CN (1) CN104822380B (ru)
AU (1) AU2013305634B2 (ru)
BR (1) BR112015003655A2 (ru)
CA (1) CA2882733C (ru)
DK (1) DK2887943T3 (ru)
EA (1) EA029278B1 (ru)
ES (1) ES2661717T3 (ru)
HK (1) HK1213482A1 (ru)
HR (1) HRP20180285T1 (ru)
HU (1) HUE036288T2 (ru)
IL (2) IL237143A (ru)
LT (1) LT2887943T (ru)
MX (1) MX355354B (ru)
NO (1) NO2970314T3 (ru)
NZ (1) NZ705313A (ru)
PL (1) PL2887943T3 (ru)
SG (2) SG10201701438QA (ru)
SI (1) SI2887943T1 (ru)
TR (1) TR201802913T4 (ru)
UA (1) UA117814C2 (ru)
WO (1) WO2014031937A1 (ru)
ZA (1) ZA201501600B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9617225B2 (en) * 2012-08-23 2017-04-11 Virostatics Srl 4,6-disubstituted aminopyrimidine derivatives have anti-HIV activity
CN104151178B (zh) * 2014-08-06 2016-08-17 江苏鼎龙科技有限公司 2-氨基-4-(β-羟乙基氨基)苯甲醚及其硫酸盐的制备方法
CN107207475A (zh) 2014-10-16 2017-09-26 拜耳医药股份有限公司 含有砜基团的氟化苯并呋喃基‑嘧啶衍生物
JP2018521988A (ja) 2015-06-16 2018-08-09 ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． ピペリジン誘導体およびその製造方法および医薬用途
CN108290903B (zh) 2015-09-29 2021-09-03 拜耳医药股份有限公司 新的大环磺酰二亚胺化合物
CN108368129B (zh) 2015-10-08 2021-08-17 拜耳医药股份有限公司 改性大环化合物
WO2017060322A2 (en) 2015-10-10 2017-04-13 Bayer Pharma Aktiengesellschaft Ptefb-inhibitor-adc
EP3190103A1 (en) * 2016-01-08 2017-07-12 Rijksuniversiteit Groningen Inhibitors of the pd-1/pd-l1 protein/protein interaction
ES2900199T3 (es) 2017-03-28 2022-03-16 Bayer Ag Novedosos compuestos macrocíclicos inhibidores de PTEFB
CA3057891A1 (en) 2017-03-28 2018-10-04 Bayer Aktiengesellschaft Novel ptefb inhibiting macrocyclic compounds
CN109761909B (zh) * 2019-01-25 2022-08-26 中国药科大学 N-(4-(嘧啶-4-氨基)苯基)磺酰胺类抑制剂或其可药用的盐、其制备方法及用途
IT201900004737A1 (it) 2019-03-29 2020-09-29 Virostatics Srl Composti aventi attività enzimatica anti-CDK4/6 e anti-CDK9 per l’inibizione della proliferazione del cancro e relativi metodi di screening per la loro identificazione.
CN111269215B (zh) * 2020-04-01 2021-10-26 中科利健制药(广州)有限公司 含氮杂环有机化合物及其制备方法和应用
CN115843296B (zh) * 2020-08-07 2024-03-08 南京迈晟科技有限责任公司 Cdk9抑制剂及其用途
WO2022195522A1 (en) * 2021-03-17 2022-09-22 Ildong Pharmaceutical Co., Ltd. Inhibitors of ano6 and their uses thereof

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US6114365A (en) 1999-08-12 2000-09-05 Pharmacia & Upjohn S.P.A. Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
US6757135B2 (en) 2000-07-28 2004-06-29 Seagate Technology Llc Leading edge bond pads
BR0113165A (pt) * 2000-08-08 2003-07-15 Ortho Mcneil Pharm Inc Derivados de 4-pirimidinamina, composições farmacêuticas e métodos relacionados
US7419984B2 (en) * 2002-10-17 2008-09-02 Cell Therapeutics, Inc. Pyrimidines and uses thereof
AU2003295776B2 (en) * 2002-11-21 2011-05-12 Novartis Vaccines And Diagnostics, Inc. 2,4,6-trisubstituted pyrimidines as phosphotidylinositol (PI) 3-kinase inhibitors and their use in the treatment of cancer
AU2004261484A1 (en) * 2003-07-30 2005-02-10 Cyclacel Limited 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors
EP1678147B1 (en) * 2003-09-15 2012-08-08 Lead Discovery Center GmbH Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases
EP1901747A2 (en) 2005-05-25 2008-03-26 Ingenium Pharmaceuticals AG Pyrimidine-based cdk inhibitors for treating pain
US8507498B2 (en) 2007-04-24 2013-08-13 Ingenium Pharmaceuticals Gmbh 4, 6-disubstituted aminopyrimidine derivatives as inhibitors of protein kinases
HU0900798D0 (en) 2009-12-21 2010-03-01 Vichem Chemie Kutato Kft 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity
WO2013175415A1 (en) * 2012-05-23 2013-11-28 Piramal Enterprises Limited Substituted pyrimidine compounds and uses thereof
US9617225B2 (en) * 2012-08-23 2017-04-11 Virostatics Srl 4,6-disubstituted aminopyrimidine derivatives have anti-HIV activity

Also Published As

Publication number Publication date
CN104822380A (zh) 2015-08-05
EP2887943B1 (en) 2017-12-06
BR112015003655A2 (pt) 2017-07-04
SG11201501041VA (en) 2015-03-30
LT2887943T (lt) 2018-05-25
NO2970314T3 (ru) 2018-05-12
KR20150064730A (ko) 2015-06-11
IL237143A (en) 2017-07-31
HRP20180285T1 (hr) 2018-04-20
MX2015002270A (es) 2015-08-14
HUE036288T2 (hu) 2018-06-28
IL253061B (en) 2018-03-29
US10294218B2 (en) 2019-05-21
WO2014031937A1 (en) 2014-02-27
DK2887943T3 (en) 2018-03-12
JP6639231B2 (ja) 2020-02-05
US20170204084A1 (en) 2017-07-20
KR102209229B1 (ko) 2021-01-29
IL253061A0 (en) 2017-08-31
PL2887943T3 (pl) 2018-05-30
AU2013305634B2 (en) 2018-03-22
UA117814C2 (uk) 2018-10-10
SG10201701438QA (en) 2017-03-30
ES2661717T3 (es) 2018-04-03
CA2882733A1 (en) 2014-02-27
HK1213482A1 (zh) 2016-07-08
US9617225B2 (en) 2017-04-11
EP2887943A1 (en) 2015-07-01
TR201802913T4 (tr) 2018-03-21
AU2013305634A1 (en) 2015-03-12
MX355354B (es) 2018-04-17
JP2015526479A (ja) 2015-09-10
CA2882733C (en) 2021-07-27
IL237143A0 (en) 2015-04-30
EA029278B1 (ru) 2018-03-30
JP6781736B2 (ja) 2020-11-04
EP2887943A4 (en) 2016-01-13
SI2887943T1 (en) 2018-04-30
US20140057911A1 (en) 2014-02-27
JP2018197233A (ja) 2018-12-13
NZ705313A (en) 2018-03-23
CN104822380B (zh) 2019-01-01
ZA201501600B (en) 2020-12-23

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