EA201590112A1 - НОВЫЕ ФАРМАЦЕВТИЧЕСКИЕ ТВЕРДЫЕ ФОРМЫ (1S,2S,3R,5S)-3-[7-[(1R,2S)-2-(3,4-ДИФТОРФЕНИЛ)ЦИКЛОПРОПИЛАМИНО]-5-(ПРОПИЛТИО)-3H-[1,2,3]ТРИАЗОЛО[4,5-d]ПИРИМИДИН-3-ИЛ]-5-(2-ГИДРОКСИЭТОКСИ)ЦИКЛОПЕНТАН-1,2-ДИОЛА - Google Patents

НОВЫЕ ФАРМАЦЕВТИЧЕСКИЕ ТВЕРДЫЕ ФОРМЫ (1S,2S,3R,5S)-3-[7-[(1R,2S)-2-(3,4-ДИФТОРФЕНИЛ)ЦИКЛОПРОПИЛАМИНО]-5-(ПРОПИЛТИО)-3H-[1,2,3]ТРИАЗОЛО[4,5-d]ПИРИМИДИН-3-ИЛ]-5-(2-ГИДРОКСИЭТОКСИ)ЦИКЛОПЕНТАН-1,2-ДИОЛА

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Publication number
EA201590112A1
EA201590112A1 EA201590112A EA201590112A EA201590112A1 EA 201590112 A1 EA201590112 A1 EA 201590112A1 EA 201590112 A EA201590112 A EA 201590112A EA 201590112 A EA201590112 A EA 201590112A EA 201590112 A1 EA201590112 A1 EA 201590112A1
Authority
EA
Eurasian Patent Office
Prior art keywords
triazolo
hydroxyethoxy
pyrimidin
propyltio
diftorfenil
Prior art date
Application number
EA201590112A
Other languages
English (en)
Other versions
EA024825B8 (ru
EA024825B1 (ru
Inventor
Шармарке Мохамед
Людмила Гейтманкова
Лудек Ридван
Марцела Ткадлецова
Ондрей Даммер
Original Assignee
Зентива К.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зентива К.С. filed Critical Зентива К.С.
Publication of EA201590112A1 publication Critical patent/EA201590112A1/ru
Publication of EA024825B1 publication Critical patent/EA024825B1/ru
Publication of EA024825B8 publication Critical patent/EA024825B8/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

Твердотельные структуры (1S,2S,3R,5S)-3-[7-[(1R,2S)-2-(3,4-дифторфенил)циклопропил]-5-(пропилтио)-3Н-[1,2,3]триазоло[4,5-d]пиримидин-3-ил]-5-(2-гидроксиэтокси)циклопентан-1,2-диола (далее рассматриваемо-го как тикагрелор) в виде стабильной сокристаллической формы З-гидрокси-2-нафтойной кислоты, а также сольвата 1,4-диоксана и способы их получения.
EA201590112A 2012-06-29 2012-06-29 Сокристалл тикагрелора с 3-гидрокси-2-нафтойной кислотой, способ его получения и применение EA024825B8 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CZ2012/000059 WO2014000719A1 (en) 2012-06-29 2012-06-29 Novel pharmaceutical solid forms of (1s,2s,3r,5s)-3-[7-[(1r,2s)-2-(3,4difluorophenyl)cyclopropylamino]-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3yl]-5-(2-hydroxyethoxy)cyclopentane-l,2-diol

Publications (3)

Publication Number Publication Date
EA201590112A1 true EA201590112A1 (ru) 2015-05-29
EA024825B1 EA024825B1 (ru) 2016-10-31
EA024825B8 EA024825B8 (ru) 2016-12-30

Family

ID=46583808

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590112A EA024825B8 (ru) 2012-06-29 2012-06-29 Сокристалл тикагрелора с 3-гидрокси-2-нафтойной кислотой, способ его получения и применение

Country Status (4)

Country Link
EP (1) EP2867235A1 (ru)
BR (1) BR112014032085A2 (ru)
EA (1) EA024825B8 (ru)
WO (1) WO2014000719A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015162630A1 (en) 2014-04-25 2015-10-29 Anlon Chemical Research Organization Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis.
WO2016116942A1 (en) 2015-01-20 2016-07-28 Anlon Chemical Research Organization Novel pharmaceutical compounds comprising ticagrelor with salts of aspirin
US10905691B2 (en) 2016-09-09 2021-02-02 Université de Liège Use of triazolo(4,5-d)pyrimidine derivatives for prevention and treatment of bacterial infection
DK3292867T3 (da) * 2016-09-09 2019-07-22 Univ Liege Ny brug af triazol(4,5-d)pyrimidinderivater til brug i forebyggelsen og behandlingen af bakteriel infektion
WO2018178997A1 (en) * 2017-03-31 2018-10-04 Natco Pharma Limited Novel crystalline form of ticagrelor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
GB0013407D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Forms of a chemical compound
CA2781182A1 (en) * 2009-12-03 2011-06-09 Astrazeneca Ab Co - crystals of a triazolo [4,5 - d] pyrimidine platelet aggregation inhibitor

Also Published As

Publication number Publication date
WO2014000719A1 (en) 2014-01-03
BR112014032085A2 (pt) 2017-06-27
EP2867235A1 (en) 2015-05-06
EA024825B8 (ru) 2016-12-30
EA024825B1 (ru) 2016-10-31

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU