EA201501070A1 - METABIOTIC COMPOSITION FOR CORRECTION OF COLONIZATION RESISTANCE OF HUMAN INTESTINE - Google Patents
METABIOTIC COMPOSITION FOR CORRECTION OF COLONIZATION RESISTANCE OF HUMAN INTESTINEInfo
- Publication number
- EA201501070A1 EA201501070A1 EA201501070A EA201501070A EA201501070A1 EA 201501070 A1 EA201501070 A1 EA 201501070A1 EA 201501070 A EA201501070 A EA 201501070A EA 201501070 A EA201501070 A EA 201501070A EA 201501070 A1 EA201501070 A1 EA 201501070A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- metabiotic
- composition
- relates
- correction
- colonization resistance
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 210000000936 intestine Anatomy 0.000 title 1
- 229910002012 Aerosil® Inorganic materials 0.000 abstract 1
- 244000063299 Bacillus subtilis Species 0.000 abstract 1
- 235000014469 Bacillus subtilis Nutrition 0.000 abstract 1
- 241000982579 Enterococcus faecium L3 Species 0.000 abstract 1
- 241000186673 Lactobacillus delbrueckii Species 0.000 abstract 1
- 241000186840 Lactobacillus fermentum Species 0.000 abstract 1
- 239000006057 Non-nutritive feed additive Substances 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 229910021536 Zeolite Inorganic materials 0.000 abstract 1
- 239000003463 adsorbent Substances 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 abstract 1
- 235000013539 calcium stearate Nutrition 0.000 abstract 1
- 239000008116 calcium stearate Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000012531 culture fluid Substances 0.000 abstract 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 229940012969 lactobacillus fermentum Drugs 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 244000005706 microflora Species 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 235000013406 prebiotics Nutrition 0.000 abstract 1
- 239000007909 solid dosage form Substances 0.000 abstract 1
- 235000019722 synbiotics Nutrition 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
- 239000010457 zeolite Substances 0.000 abstract 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Изобретение относится к области медицины и касается средства для обеспечения колонизационной резистентности микробиоценоза кишечника человека при дисбиотических нарушениях, ассоциированных с воздействием антибиотиков, за счет благотворного влияния на составляющие индигенной микрофлоры биотопа, обеспечения антагонистического эффекта в отношении патогенов бактериальной и вирусной природы и неспецифической резистентности организма. Заявляемая синбиотическая композиция выполнена в твердой дозированной форме в виде капсул и включает (мас.%.): метабиотическую составляющую, включающую стерилизованные высушенные культуральные жидкости, содержащие метаболиты Bacillus subtilis ВКПМ № В-2335 (1,9), Enterococcus faecium L-3 (4,5), Lactobacillus delbrueckii TS1-06 (4,5) и Lactobacillus fermentum TS3-06 (4,5), овсяные хлопья в качестве пребиотической составляющей (20,0), цеолит в качестве адсорбента-носителя (64,3) и стеарат кальция или аэросил в качестве технологической добавки (0,3).The invention relates to the field of medicine and relates to means for ensuring colonization resistance of the human intestinal microbiocenosis with dysbiotic disorders associated with exposure to antibiotics, due to the beneficial effect on the components of the indigenous biotope microflora, providing antagonistic effect against pathogens of bacterial and viral nature and non-specific resistance of the organism. The inventive synbiotic composition is made in solid dosage form in the form of capsules and includes (wt.%.): Metabiotic component, including sterilized dried culture fluids containing metabolites of Bacillus subtilis VKPM number B-2335 (1.9), Enterococcus faecium L-3 ( 4,5), Lactobacillus delbrueckii TS1-06 (4,5) and Lactobacillus fermentum TS3-06 (4,5), oatmeal as a prebiotic component (20.0), zeolite as an adsorbent carrier (64.3) and calcium stearate or aerosil as a processing aid (0.3).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2015113356/15A RU2589818C1 (en) | 2015-04-10 | 2015-04-10 | Metabiotic composition to ensure colonisation resistance of human intestinal microbiocenosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201501070A1 true EA201501070A1 (en) | 2016-10-31 |
| EA028962B1 EA028962B1 (en) | 2018-01-31 |
Family
ID=56371349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201501070A EA028962B1 (en) | 2015-04-10 | 2015-11-30 | Metabiotic composition to ensure colonisation resistance of human intestinal microbiocenosis |
Country Status (2)
| Country | Link |
|---|---|
| EA (1) | EA028962B1 (en) |
| RU (1) | RU2589818C1 (en) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2220199C1 (en) * | 2002-07-03 | 2003-12-27 | Алехина Галина Геннадьевна | Enterococcus strain enterococcus faecium l-3 for preparing curative-prophylactic agents and foodstuffs of curative-prophylactic designation |
| EP1869983A1 (en) * | 2006-06-23 | 2007-12-26 | Chr. Hansen A/S | Low post-acidifying lactic acid bacteria |
| RU2391395C1 (en) * | 2008-11-19 | 2010-06-10 | Галина Геннадиевна Алехина | Lactobacillus fermentum TS3-06 STRAIN USED FOR MAKING BACTERIAL PREPARATIONS AND PRODUCTION OF LIQUID SOUR MILK BROTH AS FOOD PRODUCT FOR MEDICAL AND PREVENTIVE PURPOSES |
| RU2391393C1 (en) * | 2008-11-19 | 2010-06-10 | Галина Геннадиевна Алехина | Lactobacillus delbrueckii TS1-06 STRAIN USED FOR MAKING BACTERIAL PREPARATIONS AND PRODUCTION OF LIQUID SOUR MILK BROTH AS FOOD PRODUCT FOR MEDICAL AND PREVENTIVE PURPOSES |
| ITMI20110679A1 (en) * | 2011-04-20 | 2012-10-21 | Giovanni Mogna | COMPOSITION INCLUDING PROBIOTIC BACTERES ABLE TO RESTORE THE BARRIER EFFECT OF THE STOMACH THAT IS LOST DURING THE PHARMACOLOGICAL TREATMENT OF GASTRICITY. |
| RU2476205C1 (en) * | 2012-02-15 | 2013-02-27 | Общество с ограниченной ответственностью "Лаборатория технологии оздоровительных препаратов" (ООО "Л-ТОП") | Composition with anti-infectious activity |
-
2015
- 2015-04-10 RU RU2015113356/15A patent/RU2589818C1/en active
- 2015-11-30 EA EA201501070A patent/EA028962B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2589818C1 (en) | 2016-07-10 |
| EA028962B1 (en) | 2018-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC4A | Registration of transfer of a eurasian patent by assignment | ||
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM RU |