EA201492059A1 - Твердые формы фидаксомицина и способы их получения - Google Patents

Твердые формы фидаксомицина и способы их получения

Info

Publication number
EA201492059A1
EA201492059A1 EA201492059A EA201492059A EA201492059A1 EA 201492059 A1 EA201492059 A1 EA 201492059A1 EA 201492059 A EA201492059 A EA 201492059A EA 201492059 A EA201492059 A EA 201492059A EA 201492059 A1 EA201492059 A1 EA 201492059A1
Authority
EA
Eurasian Patent Office
Prior art keywords
solid forms
methods
compositions
fidaxomycine
reception
Prior art date
Application number
EA201492059A
Other languages
English (en)
Inventor
Тамаш Фонадь
Адриенне Ковачне-Мезеи
Левенте Сурош
Эдит Надьне Арваи
Original Assignee
Тева Фармасьютикал Уоркс Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тева Фармасьютикал Уоркс Лтд. filed Critical Тева Фармасьютикал Уоркс Лтд.
Publication of EA201492059A1 publication Critical patent/EA201492059A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

Настоящее изобретение относится к твердым формам фидаксомицина, способам получения твердых форм, а также фармацевтическим композициям и составам, содержащим одну или более из твердых форм фидаксомицина, и способам получения композиций и составов. Твердые формы настоящего изобретения обладают полезными свойствами, такими как повышенная надежность и воспроизводимость получения и обработки и стабильность в композициях.
EA201492059A 2012-05-10 2013-05-10 Твердые формы фидаксомицина и способы их получения EA201492059A1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261645214P 2012-05-10 2012-05-10
US201261662542P 2012-06-21 2012-06-21
US201261693445P 2012-08-27 2012-08-27
US201261718286P 2012-10-25 2012-10-25
PCT/US2013/040541 WO2013170142A1 (en) 2012-05-10 2013-05-10 Solid state forms of fidaxomycin and processes for preparation thereof

Publications (1)

Publication Number Publication Date
EA201492059A1 true EA201492059A1 (ru) 2015-02-27

Family

ID=48446705

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201492059A EA201492059A1 (ru) 2012-05-10 2013-05-10 Твердые формы фидаксомицина и способы их получения

Country Status (6)

Country Link
EP (1) EP2855499A1 (ru)
JP (2) JP2015516438A (ru)
KR (1) KR20150001802A (ru)
CN (1) CN104768963A (ru)
EA (1) EA201492059A1 (ru)
WO (1) WO2013170142A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015127955A1 (en) * 2014-02-25 2015-09-03 Olon S.P.A. A new polymorph of tiacumicin b and process for preparation thereof
CA2940902C (en) * 2014-03-18 2022-10-25 Xellia Pharmaceuticals Aps Polymorphs and solid states of tiacumicin b
CN103880904B (zh) * 2014-03-28 2016-08-24 华北制药集团新药研究开发有限责任公司 非达霉素晶型i及其制备方法
CN103897003B (zh) * 2014-03-28 2016-07-06 华北制药集团新药研究开发有限责任公司 非达霉素晶型ii及其制备方法
CN104098637B (zh) * 2014-07-09 2017-01-04 浙江海正药业股份有限公司 一种纯化非达霉素的方法
WO2016024243A2 (en) * 2014-08-14 2016-02-18 Dr. Reddy’S Laboratories Limited Fidaxomicin polymorphs and processes for their preparation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1458512A (en) * 1973-11-22 1976-12-15 Lepetit Spa Antibiotic substance
JP2005534332A (ja) * 2002-07-29 2005-11-17 オプティマー ファーマシューティカルズ、インコーポレイテッド チアクマイシン生産
MX2007009196A (es) * 2005-01-31 2009-02-25 Optimer Pharmaceuticals Inc Compuestos macrocilicos de 18 miembros y analogos de los mismos.
US7378508B2 (en) * 2007-01-22 2008-05-27 Optimer Pharmaceuticals, Inc. Polymorphic crystalline forms of tiacumicin B

Also Published As

Publication number Publication date
EP2855499A1 (en) 2015-04-08
JP2016183193A (ja) 2016-10-20
CN104768963A (zh) 2015-07-08
JP2015516438A (ja) 2015-06-11
WO2013170142A1 (en) 2013-11-14
KR20150001802A (ko) 2015-01-06

Similar Documents

Publication Publication Date Title
EA201891264A3 (ru) Антагонисты st2l и способы их применения
EA201492002A1 (ru) Противовирусные соединения
EA201890333A1 (ru) Противовирусные соединения
EA202193044A2 (ru) Способы лечения таупатии
EA201790781A3 (ru) Противовирусные соединения
EA201992133A1 (ru) Производные пиперидино-пиримидина для лечения вирусных инфекций
EA201491811A1 (ru) АНТИ-LgR5 АНТИТЕЛА И ИММУНОКОНЪЮГАТЫ
MX2016002571A (es) Regulador de ph de transduccion.
EA201590931A1 (ru) Гетероциклические замещенные производные 2-амино-хиназолина для лечения вирусных инфекций
EA201591524A1 (ru) Производные 2-аминопиримидина для лечения вирусных инфекций
EA201591740A1 (ru) Вирусы болезни ньюкасла и их применение
EA201590887A1 (ru) Композиция
NZ743274A (en) Substituted tricyclic compounds as fgfr inhibitors
EA201492056A1 (ru) Пиримидиниловые ингибиторы тирозинкиназы
EA201691216A1 (ru) Композиции линаклотида с замедленным высвобождением
EA201692269A1 (ru) Новые композиции, их использование и способы получения
EA201500383A1 (ru) Производные 1,2,4-триазина для лечения вирусных инфекций
EA201892509A1 (ru) Антитела к гемагглютинину и способы применения
EA201492059A1 (ru) Твердые формы фидаксомицина и способы их получения
EA201491357A1 (ru) Анти-lrp5 антитела и способы их применения
EA201591712A1 (ru) Антибиотические композиции на основе цефтолозана
EA201490037A1 (ru) Антагонисты trpv4
EA201300443A1 (ru) Способ получения дигидроптеридинонов и их промежуточных продуктов
EA201590787A1 (ru) Замещенные пиридопиразины в качестве ингибиторов syk
EA201390713A1 (ru) Противовоспалительные белки и способы их получения и применения