EA201490500A1 - Многослойный высвобождающий состав - Google Patents
Многослойный высвобождающий составInfo
- Publication number
- EA201490500A1 EA201490500A1 EA201490500A EA201490500A EA201490500A1 EA 201490500 A1 EA201490500 A1 EA 201490500A1 EA 201490500 A EA201490500 A EA 201490500A EA 201490500 A EA201490500 A EA 201490500A EA 201490500 A1 EA201490500 A1 EA 201490500A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- copolymer
- composition
- peg
- combinations
- multilayer pressure
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Настоящее изобретение в целом относится к фармацевтической лекарственной форме, содержащей многослойный высвобождающий состав, образуемый посредством соэкструзии. Указанный состав, в частности, включает слой сердцевины, содержащий по меньшей мере один полимер, выбранный из поликапролактона, этилцеллюлозы или их комбинаций, и слой покрытия, содержащий по меньшей мере один сополимер, выбранный из перечня, включающего полиэтиленоксид, полиэтиленгликоль (PEG), сополимер основного бутилированного метакрилата, сополимер поливинилкапролактама, PEG и поливинилацетата и их комбинации.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11179362 | 2011-08-30 | ||
PCT/EP2012/066848 WO2013030267A1 (en) | 2011-08-30 | 2012-08-30 | Multi-layered release formulation |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201490500A1 true EA201490500A1 (ru) | 2014-06-30 |
Family
ID=46851427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201490500A EA201490500A1 (ru) | 2011-08-30 | 2012-08-30 | Многослойный высвобождающий состав |
Country Status (9)
Country | Link |
---|---|
US (1) | US20140178471A1 (ru) |
EP (1) | EP2750666B1 (ru) |
JP (1) | JP2014525423A (ru) |
CN (1) | CN103764125A (ru) |
AU (1) | AU2012300908A1 (ru) |
BR (1) | BR112014004753A2 (ru) |
CA (1) | CA2846446A1 (ru) |
EA (1) | EA201490500A1 (ru) |
WO (1) | WO2013030267A1 (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2925270C (en) * | 2013-09-27 | 2021-05-04 | Board Of Regents, The University Of Texas System | Method of preparation of biodegradable nanoparticles with recognition characteristics |
EP3052084A1 (en) * | 2013-09-30 | 2016-08-10 | Universiteit Gent | Polyurethanes as oral drug delivery platform |
WO2017192458A1 (en) * | 2016-05-03 | 2017-11-09 | Spectrix Therapeutics, LLC | Compositions and methods of providing thyroid hormone or analogs thereof |
US20200163446A1 (en) * | 2018-11-27 | 2020-05-28 | Colgate-Palmolive Company | Oral Care Implement Having a Release Component |
EP3886994A1 (en) | 2018-11-27 | 2021-10-06 | Colgate-Palmolive Company | Oral care implement having a release component |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995022962A1 (en) | 1994-02-23 | 1995-08-31 | Bm Research A/S | Controlled release composition |
DE19539361A1 (de) * | 1995-10-23 | 1997-04-24 | Basf Ag | Verfahren zur Herstellung von mehrschichtigen, festen Arzneiformen zur oralen oder rektalen Verabreichung |
DE19710008A1 (de) * | 1997-03-12 | 1998-09-17 | Basf Ag | Feste, mindestens zweiphasige Zubereitungsformen eines Opioid-Analgeticums mit verzögerter Freisetzung |
DE19753300A1 (de) * | 1997-12-01 | 1999-06-02 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
TW586944B (en) * | 1998-05-29 | 2004-05-11 | Sumitomo Pharma | Controlled release agent having a multi-layer structure |
FR2790387B1 (fr) * | 1999-03-01 | 2001-05-18 | Prographarm Laboratoires | Comprime orodispersible presentant une faible friabilite et son procede de preparation |
FR2795326B1 (fr) * | 1999-06-28 | 2001-08-31 | Adir | Composition pharmaceutique solide thermoformable a liberation controlee |
FR2818550B1 (fr) * | 2000-12-26 | 2003-02-07 | Servier Lab | Composition pharmaceutique solide thermoformable pour la liberation controle de perindopril |
GB0102342D0 (en) * | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
JP2004535431A (ja) * | 2001-06-22 | 2004-11-25 | サザン バイオシステムズ, インコーポレイテッド | ゼロ次長期放出同軸インプラント |
CA2484632C (en) * | 2002-05-07 | 2012-12-11 | Control Delivery Systems, Inc. | Processes for forming a drug delivery device |
GB0222612D0 (en) | 2002-09-30 | 2002-11-06 | Univ Gent | Controlled delivery system for bioactive substances |
DE602004026106D1 (de) | 2003-11-13 | 2010-04-29 | Psivida Inc | Injizierbares implantat mit verzögerter freisetzung mit einem bioerodierbaren matrixkern und einer bioerodierbaren haut |
JP2007517776A (ja) * | 2003-12-09 | 2007-07-05 | スフェリックス, インコーポレイテッド | カテコール官能基を有する生体接着性ポリマー |
EP1978940B1 (en) | 2006-01-19 | 2010-12-29 | Dow Global Technologies Inc. | Biologically active composition comprising ethylcellulose |
GB0811024D0 (en) * | 2008-06-17 | 2008-07-23 | E Therapeutics Plc | Sustained release treatment of depression |
CN102159193B (zh) * | 2008-09-18 | 2015-09-16 | 普渡制药公司 | 包含聚(ε-己内酯)的药物剂型 |
EP2429492B1 (de) * | 2009-05-13 | 2014-06-25 | Basf Se | Feste pharmazeutische Zubereitungen enthaltend Copolymere auf Basis von Polyethern in Kombination mit wasserschwerlöslichen Polymeren |
US9011912B2 (en) * | 2010-10-07 | 2015-04-21 | Abon Pharmaceuticals, Llc | Extended-release oral dosage forms for poorly soluble amine drugs |
-
2012
- 2012-08-30 CA CA2846446A patent/CA2846446A1/en not_active Abandoned
- 2012-08-30 BR BR112014004753A patent/BR112014004753A2/pt not_active IP Right Cessation
- 2012-08-30 US US14/239,556 patent/US20140178471A1/en not_active Abandoned
- 2012-08-30 WO PCT/EP2012/066848 patent/WO2013030267A1/en active Application Filing
- 2012-08-30 EA EA201490500A patent/EA201490500A1/ru unknown
- 2012-08-30 AU AU2012300908A patent/AU2012300908A1/en not_active Abandoned
- 2012-08-30 CN CN201280042187.0A patent/CN103764125A/zh active Pending
- 2012-08-30 JP JP2014527653A patent/JP2014525423A/ja active Pending
- 2012-08-30 EP EP12759055.2A patent/EP2750666B1/en not_active Not-in-force
Also Published As
Publication number | Publication date |
---|---|
BR112014004753A2 (pt) | 2017-03-28 |
EP2750666A1 (en) | 2014-07-09 |
CA2846446A1 (en) | 2013-03-07 |
EP2750666B1 (en) | 2017-10-04 |
WO2013030267A1 (en) | 2013-03-07 |
US20140178471A1 (en) | 2014-06-26 |
CN103764125A (zh) | 2014-04-30 |
AU2012300908A1 (en) | 2014-04-17 |
JP2014525423A (ja) | 2014-09-29 |
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