EA201300880A1 - R2в диагностике и терапии - Google Patents

R2в диагностике и терапии

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Publication number
EA201300880A1
EA201300880A1 EA201300880A EA201300880A EA201300880A1 EA 201300880 A1 EA201300880 A1 EA 201300880A1 EA 201300880 A EA201300880 A EA 201300880A EA 201300880 A EA201300880 A EA 201300880A EA 201300880 A1 EA201300880 A1 EA 201300880A1
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Eurasian Patent Office
Prior art keywords
lung
genes
development
present
cancer
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EA201300880A
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English (en)
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EA034088B1 (ru
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Ерун Марсел Мария Рогер Арсенс
Роналд Карел Луиза Ван Бремпт
Питер Йохан Петерс
Роналд Антониус Де Хогт
Маркус Корнелис Де Рёйтер
Original Assignee
Академис Зикенхёйс Лейден А/Ю Лейден Юни Медикал Ктр
Жансен Фармасетика Нв
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Publication of EA201300880A1 publication Critical patent/EA201300880A1/ru
Publication of EA034088B1 publication Critical patent/EA034088B1/ru

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Abstract

Настоящее изобретение основано на обнаружении того, что два гена, обозначенные как R2Rи R2R, играют важные роли в развитии тканей и биологии рака. В частности, авторы настоящего изобретения открыли, что эти два гена экспрессируются в клетках легких и необходимы для позднего морфогенеза легочного эпителия и эндотелия, и поддержки развития/сохранения усовершенствованной трехмерной архитектуры легких. Эти гены необходимы в программе плоскоклеточной дифференцировки и в развитии/сохранении клеточного пула предшественников (экспрессирующих Krt14). Далее, авторы настоящего изобретения установили критические роли этих генов в биологии рака, в частности в процессах, связанных с приобретением бессмертного и метастатического фенотипа (включая прогрессирование и метастазирование рака), и развитии легких и сердца. Соответственно, изобретение обеспечивает соединения и способы для применения в лечении сердечных и легочных заболеваний, а также рака.
EA201300880A 2011-02-03 2012-02-02 Ген r2r1/2 для лечения и диагностики сердечных и легочных заболеваний или состояний, а также рака EA034088B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11250127 2011-02-03
PCT/IB2012/000177 WO2012127289A1 (en) 2011-02-03 2012-02-02 R2r1/2 in diagnosis and therapy

Publications (2)

Publication Number Publication Date
EA201300880A1 true EA201300880A1 (ru) 2014-02-28
EA034088B1 EA034088B1 (ru) 2019-12-25

Family

ID=44280642

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201300880A EA034088B1 (ru) 2011-02-03 2012-02-02 Ген r2r1/2 для лечения и диагностики сердечных и легочных заболеваний или состояний, а также рака

Country Status (10)

Country Link
US (2) US20140068794A1 (ru)
EP (2) EP3581581A1 (ru)
JP (5) JP2014507943A (ru)
CN (2) CN103649110A (ru)
AU (1) AU2012232830B2 (ru)
CA (1) CA2826490C (ru)
EA (1) EA034088B1 (ru)
ES (1) ES2733369T3 (ru)
PT (1) PT2670769T (ru)
WO (1) WO2012127289A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104756163A (zh) * 2012-11-30 2015-07-01 精工爱普生株式会社 收据发行系统、打印机以及收据发行方法
GB201520258D0 (en) * 2015-11-17 2015-12-30 Academisch Ziekenhuis Leiden Modulation of ciliogenesis
JP6829663B2 (ja) 2017-07-04 2021-02-10 ミネベアミツミ株式会社 アブソリュートエンコーダ
CN112710848B (zh) * 2020-12-17 2022-04-08 温州医科大学慈溪生物医药研究院 Fgf10在制备诊断肺损伤试剂的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006089268A2 (en) * 2005-02-18 2006-08-24 The University Of North Carolina At Chapel Hill Gene and cognate protein profiles and methods to determine connective tissue markers in normal and pathologic conditions
US20070072175A1 (en) * 2005-05-13 2007-03-29 Biogen Idec Ma Inc. Nucleotide array containing polynucleotide probes complementary to, or fragments of, cynomolgus monkey genes and the use thereof
CA2668691A1 (en) * 2006-11-17 2008-06-05 Genizon Biosciences Inc. Genemap of the human genes associated with crohn's disease
US20100144538A1 (en) * 2007-03-08 2010-06-10 Genizon Biosciences Inc. Genemap of the human genes associated with schizophrenia

Also Published As

Publication number Publication date
JP2017131231A (ja) 2017-08-03
AU2012232830B2 (en) 2017-04-27
JP2021184770A (ja) 2021-12-09
JP2024012525A (ja) 2024-01-30
CN110066867A (zh) 2019-07-30
JP2014507943A (ja) 2014-04-03
US20170198357A1 (en) 2017-07-13
WO2012127289A1 (en) 2012-09-27
CN103649110A (zh) 2014-03-19
EP2670769B1 (en) 2019-03-27
WO2012127289A8 (en) 2012-11-29
AU2012232830A1 (en) 2013-09-05
PT2670769T (pt) 2019-06-28
US10975441B2 (en) 2021-04-13
EA034088B1 (ru) 2019-12-25
EP2670769A1 (en) 2013-12-11
US20140068794A1 (en) 2014-03-06
CA2826490C (en) 2020-06-02
CN110066867B (zh) 2024-01-12
JP2019162143A (ja) 2019-09-26
CA2826490A1 (en) 2012-09-27
ES2733369T3 (es) 2019-11-28
EP3581581A1 (en) 2019-12-18

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