EA201291302A1 - Синтез циклопентахиназолинов - Google Patents

Синтез циклопентахиназолинов

Info

Publication number
EA201291302A1
EA201291302A1 EA201291302A EA201291302A EA201291302A1 EA 201291302 A1 EA201291302 A1 EA 201291302A1 EA 201291302 A EA201291302 A EA 201291302A EA 201291302 A EA201291302 A EA 201291302A EA 201291302 A1 EA201291302 A1 EA 201291302A1
Authority
EA
Eurasian Patent Office
Prior art keywords
synthesis
cyclopentachinasolins
aminocyclopenta
onx
quinazolines
Prior art date
Application number
EA201291302A
Other languages
English (en)
Inventor
Джеймс Алан Кершен
Александр Джеймс Бриджес
Шон Марк Далзил
Оливье Дапремон
Хьюнцзюн Ким
Эндрю С. Томпсон
Джеймс Роберт Зеллер
Original Assignee
Оникс Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Оникс Фармасьютикалз, Инк. filed Critical Оникс Фармасьютикалз, Инк.
Publication of EA201291302A1 publication Critical patent/EA201291302A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Предложен способ получения 6-аминоциклопента[g]хиназолинов в энантиомерно обогащенной форме. В частности, указанный способ может быть применим для синтеза N-{N-{4-[N-((6S)-2-гидроксиметил-4-оксо-3,4,7,8-тетрагидро-6Н-циклопента[g]хиназолин-6-ил)-N-(проп-2-инил)амино]бензоил}-L-γ-глутамил}-D-глутаминовой кислоты (ONX-0801).
EA201291302A 2010-07-19 2011-07-15 Синтез циклопентахиназолинов EA201291302A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39986110P 2010-07-19 2010-07-19
PCT/US2011/001235 WO2012011939A2 (en) 2010-07-19 2011-07-15 Synthesis of cyclopentaquinazolines

Publications (1)

Publication Number Publication Date
EA201291302A1 true EA201291302A1 (ru) 2013-09-30

Family

ID=45497340

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201291302A EA201291302A1 (ru) 2010-07-19 2011-07-15 Синтез циклопентахиназолинов

Country Status (13)

Country Link
US (1) US8809526B2 (ru)
EP (1) EP2595966B1 (ru)
KR (1) KR20130056887A (ru)
CN (1) CN103517897A (ru)
AU (1) AU2011280235A1 (ru)
BR (1) BR112013001350A2 (ru)
CA (1) CA2804889A1 (ru)
CO (1) CO6650369A2 (ru)
EA (1) EA201291302A1 (ru)
IL (1) IL223926A0 (ru)
MX (1) MX2013000433A (ru)
SG (1) SG187011A1 (ru)
WO (1) WO2012011939A2 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105237416A (zh) * 2015-10-14 2016-01-13 湖南华腾制药有限公司 一种5-氨基茚酮的合成方法
US10611705B2 (en) 2017-05-03 2020-04-07 Exxonmobil Chemical Patents Inc. Process for conversion of acyclic C5 compounds to cyclic C5 compounds and formulated catalyst compositions used therein
WO2018204036A1 (en) * 2017-05-03 2018-11-08 Exxonmobil Chemical Patents Inc. Process for conversion of acyclic c5 compounds to cyclic c5 compounds and formulated catalyst compositions used therein
GB201707864D0 (en) 2017-05-16 2017-06-28 Inst Of Cancer Research: Royal Cancer Hospital Platinum-reistant cancer treatment

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9223352D0 (en) 1992-11-06 1992-12-23 Ici Plc Tricyclic compounds
GB2272217B (en) 1992-11-06 1996-07-31 Zeneca Ltd Anti-cancer cyclopentaquinazoline tricyclic derivatives
GB9408936D0 (en) 1994-05-05 1994-06-22 Cancer Res Inst Anti-cancer compounds
GB9904275D0 (en) 1999-02-24 1999-04-21 Cancer Res Campaign Tech Anti-cancer compounds
GB0121214D0 (en) * 2001-08-31 2001-10-24 Btg Int Ltd Synthetic method
WO2003020300A1 (en) 2001-08-31 2003-03-13 Btg International Limited Use of cyclopenta[g]quinazoline derivatives for treating cancer
DE60237902D1 (de) 2001-08-31 2010-11-18 Btg Int Ltd ANTIKREBS-CYCLOPENTAiG CHINAZOLINE-DERIVATE
US7250611B2 (en) 2003-12-02 2007-07-31 3M Innovative Properties Company LED curing apparatus and method
WO2005084205A2 (en) * 2004-02-27 2005-09-15 Teva Pharmaceutical Industries, Ltd. Diamino thiazoloindan derivatives and their use
EP2051978A2 (en) * 2006-05-18 2009-04-29 Arena Pharmaceuticals, Inc. Acetamide derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto

Also Published As

Publication number Publication date
SG187011A1 (en) 2013-02-28
CO6650369A2 (es) 2013-04-15
US8809526B2 (en) 2014-08-19
IL223926A0 (en) 2013-03-05
BR112013001350A2 (pt) 2016-05-17
WO2012011939A2 (en) 2012-01-26
EP2595966A4 (en) 2015-12-09
CA2804889A1 (en) 2012-01-26
CN103517897A (zh) 2014-01-15
WO2012011939A3 (en) 2014-04-03
MX2013000433A (es) 2013-05-28
KR20130056887A (ko) 2013-05-30
EP2595966A2 (en) 2013-05-29
EP2595966B1 (en) 2020-10-28
US20130211082A1 (en) 2013-08-15
AU2011280235A1 (en) 2013-03-07

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