EA201201482A1 - Селективные ингибиторы интегрина - Google Patents
Селективные ингибиторы интегринаInfo
- Publication number
- EA201201482A1 EA201201482A1 EA201201482A EA201201482A EA201201482A1 EA 201201482 A1 EA201201482 A1 EA 201201482A1 EA 201201482 A EA201201482 A EA 201201482A EA 201201482 A EA201201482 A EA 201201482A EA 201201482 A1 EA201201482 A1 EA 201201482A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- integrine
- inhibitors
- selective
- methods
- selectively
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Это изобретение предусматривает способы для селективного антагонизирования гетеродимера интегрина α4β1 у субъекта, который в этом нуждается, а предпочтительно - у человека. Способы этого изобретения используют конъюгаты, включающие два или более мелкомолекулярных антагонистов α4β1, ковалентно присоединенных к биосовместимому полимеру. Эти способы селективного ингибирования α4β1 могут быть использованы для модулирования как нормальных, так и патологических биологических процессов, опосредованных, по меньшей мере, частично активностью α4β1.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33012210P | 2010-04-30 | 2010-04-30 | |
US39228810P | 2010-10-12 | 2010-10-12 | |
US201161516846P | 2011-04-08 | 2011-04-08 | |
PCT/US2011/034721 WO2011137418A1 (en) | 2010-04-30 | 2011-05-02 | Selective integrin inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201201482A1 true EA201201482A1 (ru) | 2013-03-29 |
Family
ID=44260795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201201482A EA201201482A1 (ru) | 2010-04-30 | 2011-05-02 | Селективные ингибиторы интегрина |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP2563405A1 (ru) |
JP (1) | JP2013525435A (ru) |
KR (1) | KR20130081651A (ru) |
CN (1) | CN102883750A (ru) |
AU (1) | AU2011245140A1 (ru) |
CA (1) | CA2797974A1 (ru) |
EA (1) | EA201201482A1 (ru) |
WO (1) | WO2011137418A1 (ru) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3722808A1 (en) * | 2010-10-25 | 2020-10-14 | Biogen MA Inc. | Methods for determining differences in alpha-4 integrin activity by correlating differences in svcam and/or smadcam levels |
EP3551034A1 (en) | 2016-12-07 | 2019-10-16 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
TW201834710A (zh) | 2016-12-14 | 2018-10-01 | 美商寶珍那提公司 | 以整合素抑制劑治療胃腸道疾病 |
WO2019246455A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
WO2020106757A1 (en) | 2018-11-19 | 2020-05-28 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
EP3870261B1 (en) | 2019-12-13 | 2024-01-31 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101035563B (zh) * | 2004-07-08 | 2012-03-28 | 艾伦药物公司 | 包括聚合物部分的多价vla-4拮抗剂 |
WO2006127584A1 (en) | 2005-05-20 | 2006-11-30 | Elan Pharmaceuticals, Inc. | Imidazolone phenylalanine derivatives as vla-4 antagonists |
CA2614200A1 (en) | 2005-07-08 | 2007-01-18 | Elan Pharmaceuticals, Inc. | Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds |
EP2019690A2 (en) | 2006-05-22 | 2009-02-04 | Elan Pharmaceuticals Inc. | Preparation of polymer conjugates of vla-4 antagonists via a mitsunobu's reaction |
EP2231185A4 (en) * | 2007-12-07 | 2012-06-27 | Elan Pharm Inc | METHOD AND COMPOSITIONS FOR TREATING LIQUID TUMORS |
-
2011
- 2011-05-02 EA EA201201482A patent/EA201201482A1/ru unknown
- 2011-05-02 JP JP2013508077A patent/JP2013525435A/ja not_active Withdrawn
- 2011-05-02 WO PCT/US2011/034721 patent/WO2011137418A1/en active Application Filing
- 2011-05-02 CA CA2797974A patent/CA2797974A1/en not_active Abandoned
- 2011-05-02 EP EP11725997A patent/EP2563405A1/en not_active Withdrawn
- 2011-05-02 KR KR1020127028463A patent/KR20130081651A/ko not_active Application Discontinuation
- 2011-05-02 AU AU2011245140A patent/AU2011245140A1/en not_active Abandoned
- 2011-05-02 CN CN201180021962XA patent/CN102883750A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2797974A1 (en) | 2011-11-03 |
AU2011245140A1 (en) | 2012-12-20 |
JP2013525435A (ja) | 2013-06-20 |
KR20130081651A (ko) | 2013-07-17 |
EP2563405A1 (en) | 2013-03-06 |
WO2011137418A1 (en) | 2011-11-03 |
CN102883750A (zh) | 2013-01-16 |
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