EA201070536A1 - Ретиноидное пролекарственное соединение - Google Patents

Ретиноидное пролекарственное соединение

Info

Publication number
EA201070536A1
EA201070536A1 EA201070536A EA201070536A EA201070536A1 EA 201070536 A1 EA201070536 A1 EA 201070536A1 EA 201070536 A EA201070536 A EA 201070536A EA 201070536 A EA201070536 A EA 201070536A EA 201070536 A1 EA201070536 A1 EA 201070536A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cooh
hydrogen atom
group
retinoid
compound
Prior art date
Application number
EA201070536A
Other languages
English (en)
Other versions
EA016767B1 (ru
Inventor
Хидеаки Муратаке
Коити Судо
Original Assignee
Рисерч Фаундейшн Ицуу Лэборетери
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рисерч Фаундейшн Ицуу Лэборетери filed Critical Рисерч Фаундейшн Ицуу Лэборетери
Publication of EA201070536A1 publication Critical patent/EA201070536A1/ru
Publication of EA016767B1 publication Critical patent/EA016767B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the nitrogen atom of at least one of the carboxamide groups further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/88—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having the nitrogen atom of at least one of the carboxamide groups further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/30—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Предложено соединение общей формулы (I)где R-Rпредставляют собой атом водорода, алкильную группу или триалкилсилильную группу; Х представляет собой -NH-СО-, -CO-NH-, -N(COR)-CO-, -CO-N(COR)- (Rи Rпредставляют собой низшую алкоксигруппу или карбоксизамещенную фенильную группу) и т.д.; Z представляет собой -Y-CH(R)-COOH, -СНО, -СН=СН-СООН или -COOR(Y представляет собой одинарную связь, -CH-, -СН(ОН)-, -СО-, -CO-NH- или -CO-NH-CH-CO-NH-, Rпредставляет собой атом водорода или низшую алкильную группу и Rпредставляет собой атом водорода, -СН(R)-COOH (Rпредставляет собой атом водорода, низшую алкильную группу или гидроксильную группу), -[СНСН-O]-СН-СН-ОН, -СН-O-[СНСН-O]-СН-ОН или -[СН(СН)-СО-O]-СН(СН)-COOH (m, n и p представляют собой целое число от 1 до 100)), его соль или сложный эфир, которое обладает способностью превращаться в ретиноид после абсорбции in vivo.
EA201070536A 2007-10-31 2007-10-31 Ретиноидное пролекарственное соединение EA016767B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/071184 WO2009057199A1 (ja) 2007-10-31 2007-10-31 レチノイドプロドラッグ化合物

Publications (2)

Publication Number Publication Date
EA201070536A1 true EA201070536A1 (ru) 2010-10-29
EA016767B1 EA016767B1 (ru) 2012-07-30

Family

ID=40590609

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070536A EA016767B1 (ru) 2007-10-31 2007-10-31 Ретиноидное пролекарственное соединение

Country Status (9)

Country Link
US (1) US8633335B2 (ru)
EP (1) EP2216322A4 (ru)
JP (1) JPWO2009057199A1 (ru)
CN (1) CN101888991A (ru)
AU (1) AU2007360907A1 (ru)
CA (1) CA2703684A1 (ru)
EA (1) EA016767B1 (ru)
NZ (1) NZ585587A (ru)
WO (1) WO2009057199A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200922554A (en) 2007-10-11 2009-06-01 Taiho Pharmaceutical Co Ltd Bis(trimethylsilyl)phenyl compound or salt thereof, and use thereof
JP5193400B2 (ja) * 2011-07-05 2013-05-08 公益財団法人乙卯研究所 重水素化フェニルプロピオン酸誘導体
CN103664680A (zh) * 2012-09-26 2014-03-26 山东鲁北药业有限公司 一种他米巴罗汀合成的新工艺
CN114401717A (zh) 2019-06-04 2022-04-26 赛诺维信制药公司 修饰释放配制品及其用途
WO2020263960A1 (en) * 2019-06-28 2020-12-30 Carl Wagner Compositions comprising a retinoid x receptor (rxr) agonist, a retinoic acid receptor (rar) agonist, or a dual rxr/rar agonist

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6122047A (ja) 1984-07-07 1986-01-30 Koichi Shiyudo 安息香酸誘導体
JPS6176440A (ja) 1984-09-19 1986-04-18 Koichi Shiyudo 安息香酸誘導体
JP2761023B2 (ja) 1989-03-20 1998-06-04 大鵬薬品工業株式会社 新規安息香酸誘導体及びその製造方法
US5675024A (en) 1995-11-22 1997-10-07 Allergan Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity
FR2759368B1 (fr) 1997-02-10 2001-06-01 Galderma Rech Dermatologique Composes biaromatiques, compositions les contenant et utilisations
AU1052599A (en) 1997-11-12 1999-05-31 Institute Of Medicinal Molecular Design. Inc. Retinoid receptor agonists
WO2000020358A2 (en) 1998-08-20 2000-04-13 Agouron Pharmaceuticals, Inc. NON-PEPTIDE GnRH AGENTS, METHODS AND INTERMEDIATES FOR THEIR PREPARATION
WO2005056516A1 (en) 2003-12-08 2005-06-23 Galderma Research & Development, S.N.C. Biphenyl derivatives useful as ligands that activate the rar receptors, process for preparing them and use thereof in human medicine and in cosmetics

Also Published As

Publication number Publication date
JPWO2009057199A1 (ja) 2011-03-10
WO2009057199A1 (ja) 2009-05-07
US8633335B2 (en) 2014-01-21
US20100286427A1 (en) 2010-11-11
CA2703684A1 (en) 2009-05-07
EP2216322A4 (en) 2011-09-21
NZ585587A (en) 2012-04-27
AU2007360907A1 (en) 2009-05-07
EA016767B1 (ru) 2012-07-30
CN101888991A (zh) 2010-11-17
EP2216322A1 (en) 2010-08-11

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU