EA201000752A1 - Фармацевтическая композиция, содержащая эзетимиб - Google Patents

Фармацевтическая композиция, содержащая эзетимиб

Info

Publication number
EA201000752A1
EA201000752A1 EA201000752A EA201000752A EA201000752A1 EA 201000752 A1 EA201000752 A1 EA 201000752A1 EA 201000752 A EA201000752 A EA 201000752A EA 201000752 A EA201000752 A EA 201000752A EA 201000752 A1 EA201000752 A1 EA 201000752A1
Authority
EA
Eurasian Patent Office
Prior art keywords
amount
pharmaceutical composition
composition containing
ezetimib
ezetimibe
Prior art date
Application number
EA201000752A
Other languages
English (en)
Other versions
EA022269B1 (ru
Inventor
Ганеш Гат
Пасупулети Джиридхара-Рао
Джавед Хуссаин
Original Assignee
Рациофарм Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40416944&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201000752(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Рациофарм Гмбх filed Critical Рациофарм Гмбх
Publication of EA201000752A1 publication Critical patent/EA201000752A1/ru
Publication of EA022269B1 publication Critical patent/EA022269B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)

Abstract

В заявке описаны новые композиции, содержащие эзетимиб в качестве действующего вещества. В заявке описана, в частности, фармацевтическая композиция, содержащая эзетимиб в количестве от 5 до 20 мас.%, разбавитель в количестве от 50 до 85 мас.%, разрыхлитель в количестве от 3 до 25 мас.%, связующее в количестве от 1 до 10 мас.% и смазывающее вещество в количестве от 0,5 до 1 мас.% и отличающаяся тем, что эзетимиб имеет гранулометрический состав со значением d(0,9) в пределах от 5 до 35 мкм и значением d(0,5) в пределах от 3 до 20 мкм, а также описаны способы приготовления таких композиций.
EA201000752A 2007-12-10 2008-12-09 Фармацевтическая композиция, содержащая эзетимиб EA022269B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2579DE2007 2007-12-10
PCT/EP2008/010431 WO2009074286A2 (en) 2007-12-10 2008-12-09 Pharmaceutical formulation comprising ezetimibe

Publications (2)

Publication Number Publication Date
EA201000752A1 true EA201000752A1 (ru) 2010-12-30
EA022269B1 EA022269B1 (ru) 2015-12-30

Family

ID=40416944

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000752A EA022269B1 (ru) 2007-12-10 2008-12-09 Фармацевтическая композиция, содержащая эзетимиб

Country Status (7)

Country Link
US (1) US8858994B2 (ru)
EP (2) EP2217214B1 (ru)
CA (1) CA2708159C (ru)
EA (1) EA022269B1 (ru)
ES (1) ES2639995T3 (ru)
UA (1) UA103179C2 (ru)
WO (1) WO2009074286A2 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001041512A1 (en) 1999-12-01 2001-06-07 The Trustees Of Princeton University Complexes of form l2mx as phosphorescent dopants for organic leds
EP2127641A1 (en) 2008-05-26 2009-12-02 Inke, S.A. Micronisable form of salmeterol xinafoate
EP2216016A1 (en) * 2009-02-06 2010-08-11 LEK Pharmaceuticals d.d. Process for the preparation of a pharmaceutical composition comprising ezetimibe
HUP1000327A2 (en) 2010-06-18 2012-01-30 Druggability Technologies Ip Holdco Jersey Ltd Composition containing nanostructured ezetibime and process for it's preparation
EP2468258A1 (en) * 2010-12-22 2012-06-27 LEK Pharmaceuticals d.d. Process for the preparation of a pharmaceutical composition comprising a low soluble pharmaceutically active ingredient
WO2013066279A1 (en) * 2011-10-13 2013-05-10 Mahmut Bilgic Solid dosage forms comprising ezetimibe
CN104173307A (zh) * 2014-08-29 2014-12-03 四川制药制剂有限公司 依折麦布片剂的制备方法
US10912751B2 (en) 2015-03-13 2021-02-09 Esperion Therapeutics, Inc. Fixed dose combinations and formulations comprising ETC1002 and ezetimibe and methods of treating or reducing the risk of cardiovascular disease
MA41793A (fr) 2015-03-16 2018-01-23 Esperion Therapeutics Inc Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire
EP3437636A1 (en) 2017-08-02 2019-02-06 Adamed sp. z o.o. Pharmaceutical composition comprising ezetimibe
US11622939B2 (en) * 2017-11-23 2023-04-11 Zhejiang Hisun Pharmaceutical Co., Ltd. HS-25 tablet and preparation method therefor
WO2021220236A1 (en) * 2020-05-01 2021-11-04 Cadila Healthcare Limited Pharmaceutical compositions for combination therapy
WO2024042061A1 (en) * 2022-08-22 2024-02-29 Newamsterdam Pharma B.V. Obicetrapib and ezetimibe combination treatment and fixed dose pharmaceutical compositions
WO2024041746A1 (en) * 2022-08-22 2024-02-29 Newamsterdam Pharma B.V. Fixed dose combination composition of obicetrapib and ezetimibe

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
MX9606319A (es) 1994-06-20 1997-05-31 Schering Corp Compuestos de acetidinonas sustituidas utiles como agentes hipocolesterolemicos.
DK1353696T3 (da) 2001-01-26 2007-04-10 Schering Corp Kombinationer af peroxisomproliferatoraktiveret receptor (PPAR)-aktivator(er) og sterolabsorptionsinhibitor(er) og behandlinger til vaskulære indikationer
US9173847B2 (en) * 2003-10-10 2015-11-03 Veloxis Pharmaceuticals A/S Tablet comprising a fibrate
WO2006060808A1 (en) 2004-12-03 2006-06-08 Teva Pharmaceutical Industries Ltd. Ezetimibe polymorphs
EP1741427A1 (en) 2005-07-06 2007-01-10 KRKA, D.D., Novo Mesto Pharmaceutical composition comprising simvastatin and ezetimibe
US20070049748A1 (en) 2005-08-26 2007-03-01 Uppala Venkata Bhaskara R Preparation of ezetimibe
RU2008136765A (ru) 2006-03-06 2010-04-20 Тева Фармасьютикл Индастриес Лтд. (Il) Композиции эзетимиба
US20070275052A1 (en) 2006-05-24 2007-11-29 Glenmark Pharmaceuticals Limited Pharmaceutical compositions containing sterol inhibitors
WO2008032338A2 (en) 2006-09-11 2008-03-20 Manne Satyanarayana Reddy Improved process for the preparation of ezetimibe and its intermediates
US8500960B2 (en) 2007-01-20 2013-08-06 Dais Analytic Corporation Multi-phase selective mass transfer through a membrane
US20130190487A1 (en) 2007-01-24 2013-07-25 Krka Process for the preparation of ezetimibe and derivatives thereof
WO2008101723A2 (en) 2007-02-23 2008-08-28 Krka Pharmaceutical composition containing a cholesterol absorption inhibitor
WO2009077573A2 (en) 2007-12-17 2009-06-25 Krka, Tovarna Zdravil, D.D., Novo Mesto Suspension comprising non-micronized ezetimibe micro-particles

Also Published As

Publication number Publication date
EP2217214B1 (en) 2017-07-19
US8858994B2 (en) 2014-10-14
UA103179C2 (ru) 2013-09-25
WO2009074286A2 (en) 2009-06-18
WO2009074286A3 (en) 2009-07-30
ES2639995T3 (es) 2017-10-31
CA2708159A1 (en) 2009-06-18
CA2708159C (en) 2016-01-26
US20100291207A1 (en) 2010-11-18
EA022269B1 (ru) 2015-12-30
EP2217214A2 (en) 2010-08-18
EP2965752A1 (en) 2016-01-13

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU