EA200800099A1 - COMPOSITIONS OF MEGESTROL NANOPARTICLES - Google Patents

COMPOSITIONS OF MEGESTROL NANOPARTICLES

Info

Publication number
EA200800099A1
EA200800099A1 EA200800099A EA200800099A EA200800099A1 EA 200800099 A1 EA200800099 A1 EA 200800099A1 EA 200800099 A EA200800099 A EA 200800099A EA 200800099 A EA200800099 A EA 200800099A EA 200800099 A1 EA200800099 A1 EA 200800099A1
Authority
EA
Eurasian Patent Office
Prior art keywords
megestrol
compositions
nanoparticles
composition
particle size
Prior art date
Application number
EA200800099A
Other languages
Russian (ru)
Inventor
Дуглас Хоуви
Джон Пруйтт
Тула Рюде
Original Assignee
Элан Фарма Интернэшнл Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Элан Фарма Интернэшнл Лтд. filed Critical Элан Фарма Интернэшнл Лтд.
Publication of EA200800099A1 publication Critical patent/EA200800099A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

Настоящее изобретение касается композиций наночастиц, включающих мегестрол. Частицы мегестрола в композиции имеют средний эффективный размер частиц меньше чем примерно 2000 нм.The present invention relates to nanoparticle compositions comprising megestrol. The megestrol particles in the composition have an average effective particle size of less than about 2000 nm.

EA200800099A 2005-06-22 2006-06-22 COMPOSITIONS OF MEGESTROL NANOPARTICLES EA200800099A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69312705P 2005-06-22 2005-06-22
PCT/US2006/024349 WO2007002315A2 (en) 2005-06-22 2006-06-22 Nanoparticulate megestrol formulations

Publications (1)

Publication Number Publication Date
EA200800099A1 true EA200800099A1 (en) 2008-06-30

Family

ID=37595838

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800099A EA200800099A1 (en) 2005-06-22 2006-06-22 COMPOSITIONS OF MEGESTROL NANOPARTICLES

Country Status (13)

Country Link
EP (1) EP1901713A2 (en)
JP (1) JP2008546796A (en)
KR (1) KR20080024213A (en)
CN (1) CN101242810A (en)
AU (1) AU2006262144A1 (en)
BR (1) BRPI0612665A2 (en)
CA (1) CA2613466A1 (en)
EA (1) EA200800099A1 (en)
IL (1) IL188322A0 (en)
MX (1) MX2008000396A (en)
NO (1) NO20080403L (en)
WO (1) WO2007002315A2 (en)
ZA (1) ZA200800376B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105147605B (en) * 2015-06-24 2019-04-19 中国人民解放军军事医学科学院毒物药物研究所 Progesterone nano-composition and preparation method thereof
CN105687027A (en) * 2016-01-26 2016-06-22 中国科学院生物物理研究所 Alcohol-free amino acid type rinse-free foam washing solution
CN105769763A (en) * 2016-05-25 2016-07-20 西安德天药业股份有限公司 Megestrol acetate nanosuspension and preparation method and application thereof
CN108309933A (en) * 2018-03-19 2018-07-24 青岛国海生物制药有限公司 A kind of oral megestrol acetate nanosuspension and preparation method thereof
CN108409821A (en) * 2018-03-19 2018-08-17 青岛国海生物制药有限公司 A kind of preparation method and megestrol acetate of megestrol acetate nanocrystal
CN112891309B (en) * 2019-11-19 2022-07-26 北京化工大学 Megestrol acetate nano dry suspension and preparation method thereof
CN111643463A (en) * 2020-07-08 2020-09-11 西安远大德天药业股份有限公司 Megestrol acetate dispersible tablet and preparation method thereof
CN111930838B (en) * 2020-07-23 2023-05-16 金陵科技学院 Time-oriented distributed archive management method

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1227626B (en) * 1988-11-28 1991-04-23 Vectorpharma Int SUPPORTED DRUGS WITH INCREASED DISSOLUTION SPEED AND PROCEDURE FOR THEIR PREPARATION
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US7101576B2 (en) * 2002-04-12 2006-09-05 Elan Pharma International Limited Nanoparticulate megestrol formulations
ES2380318T3 (en) * 2002-04-12 2012-05-10 Alkermes Pharma Ireland Limited Megestrol nanoparticular formulations
JP4787165B2 (en) * 2003-11-05 2011-10-05 エラン ファーマ インターナショナル，リミティド Nanoparticle compositions having peptides as surface stabilizers

Also Published As

Publication number Publication date
BRPI0612665A2 (en) 2010-11-30
NO20080403L (en) 2008-03-19
AU2006262144A1 (en) 2007-01-04
JP2008546796A (en) 2008-12-25
WO2007002315A3 (en) 2007-04-05
WO2007002315A2 (en) 2007-01-04
CA2613466A1 (en) 2007-01-04
KR20080024213A (en) 2008-03-17
IL188322A0 (en) 2008-04-13
EP1901713A2 (en) 2008-03-26
MX2008000396A (en) 2009-02-23
CN101242810A (en) 2008-08-13
ZA200800376B (en) 2009-03-25

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