EA200702377A1 - Производные бензотриазола в качестве антагонистов каннабиноидного рецептора - Google Patents

Производные бензотриазола в качестве антагонистов каннабиноидного рецептора

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Publication number
EA200702377A1
EA200702377A1 EA200702377A EA200702377A EA200702377A1 EA 200702377 A1 EA200702377 A1 EA 200702377A1 EA 200702377 A EA200702377 A EA 200702377A EA 200702377 A EA200702377 A EA 200702377A EA 200702377 A1 EA200702377 A1 EA 200702377A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hydrogen
phenyl
cannabinoid
antagonists
6alkyl
Prior art date
Application number
EA200702377A
Other languages
English (en)
Inventor
Моник Дженни Мари Бервар
Йоаннес Теодорус Мария Линдерс
Питер Джон Кинг
Герт Мария Роберт Ван Хекке
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200702377A1 publication Critical patent/EA200702377A1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Данное изобретение относится к группе производных бензотриазола, приведенных ниже, которые являются эффективными модуляторами каннабиноидного рецептора CB(известные как антагонисты или обратные агонисты), эффективные при лечении ожирения, психических и неврологических нарушений, а также других заболеваний, в которые вовлечена нейрональная передача каннабиноид-CB(Current Opinion in Drug Discovery & Development 2004 7(4):498-506), их фармацевтически приемлемым кислотно-аддитивным солям и стереоизомерным формам, где Rпредставляет собой водород, галоген, трифторметил, Салкил, Салкилокси- или Салкилоксикарбонил-; Rпредставляет собой водород, фенил, Сциклоалкил или Cалкил, необязательно замещенный Ar; Rпредставляет собой водород, гидроксил или Cалкил; Arпредставляет собой фенил или фенил, замещенный заместителями, вплоть до трех; и Het представляет собой моноциклический 5- или 6-членный частично насыщенный или ароматический гетероцикл, выбранный из фуранила, тиенила, пирролила, оксазолила, тиазолила, имидазолила, пиразолила, изоксазолила, изотиазолила, оксадиазолила, триазолила, тиадиазолила, пиримидинила, пиридинила, пиразинила, триазинила, пиридазинила, 2Н-пиранила или 4Н-пиранила, где указанный гетероцикл необязательно замещен Cалкилом.
EA200702377A 2005-04-29 2006-04-24 Производные бензотриазола в качестве антагонистов каннабиноидного рецептора EA200702377A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05103597 2005-04-29
PCT/EP2006/061787 WO2006117307A2 (en) 2005-04-29 2006-04-24 Benzotriazole derivatives as cannabinoid receptor antagonists

Publications (1)

Publication Number Publication Date
EA200702377A1 true EA200702377A1 (ru) 2008-02-28

Family

ID=35841851

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200702377A EA200702377A1 (ru) 2005-04-29 2006-04-24 Производные бензотриазола в качестве антагонистов каннабиноидного рецептора

Country Status (13)

Country Link
US (1) US20080194656A1 (ru)
EP (1) EP1874304B1 (ru)
JP (1) JP5137816B2 (ru)
KR (1) KR20080000584A (ru)
CN (1) CN101166529B (ru)
AU (1) AU2006243246A1 (ru)
BR (1) BRPI0609866A2 (ru)
CA (1) CA2600052A1 (ru)
DE (1) DE602006007832D1 (ru)
EA (1) EA200702377A1 (ru)
ES (1) ES2329614T3 (ru)
MX (1) MX2007013454A (ru)
WO (1) WO2006117307A2 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010141360A1 (en) * 2009-06-05 2010-12-09 Merck Sharp & Dohme Corp. Biaryl benzotriazole derivatives
CA2846187A1 (en) 2011-08-23 2013-02-28 Endo Pharmaceuticals Inc. Pyrimido-pyridazinone compounds and use thereof
US8809372B2 (en) 2011-09-30 2014-08-19 Asana Biosciences, Llc Pyridine derivatives
EP2986587B1 (en) 2013-04-17 2023-11-22 Sharon Anavi-Goffer Cb2 receptor ligands for the treatment of psychiatric disorders
WO2022128050A1 (en) 2020-12-14 2022-06-23 Symrise Ag Medicament for fighting inflammation and pain

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943574A (en) * 1987-06-01 1990-07-24 Janssen Pharmaceutica N.V. (1H-azol-1-ylmethyl) substituted benzotriazole derivatives and pharmaceutical compositions containing them
NZ224714A (en) * 1987-06-01 1990-03-27 Janssen Pharmaceutica Nv Substituted benzotriazole derivatives and pharmaceutical compositions
AR041268A1 (es) * 2002-09-19 2005-05-11 Solvay Pharm Bv Derivados de la 1h -1,2,4- triazol-3-carboxamida que tienen actividad agonista, agonista parcial, agonista inversa o antagonista del receptor cb 1 de cannabinoide y composiciones farmaceuticas que los contienen
JP4786147B2 (ja) * 2003-06-26 2011-10-05 武田薬品工業株式会社 カンナビノイド受容体調節剤

Also Published As

Publication number Publication date
BRPI0609866A2 (pt) 2010-05-11
KR20080000584A (ko) 2008-01-02
CA2600052A1 (en) 2006-11-09
EP1874304B1 (en) 2009-07-15
JP5137816B2 (ja) 2013-02-06
EP1874304A2 (en) 2008-01-09
CN101166529B (zh) 2011-11-16
DE602006007832D1 (de) 2009-08-27
AU2006243246A1 (en) 2006-11-09
JP2008539197A (ja) 2008-11-13
WO2006117307B1 (en) 2007-04-26
WO2006117307A2 (en) 2006-11-09
MX2007013454A (es) 2008-01-21
US20080194656A1 (en) 2008-08-14
CN101166529A (zh) 2008-04-23
ES2329614T3 (es) 2009-11-27
WO2006117307A3 (en) 2007-03-08

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