EA200701433A1 - RECEIVING IRBISARTANA - Google Patents
RECEIVING IRBISARTANAInfo
- Publication number
- EA200701433A1 EA200701433A1 EA200701433A EA200701433A EA200701433A1 EA 200701433 A1 EA200701433 A1 EA 200701433A1 EA 200701433 A EA200701433 A EA 200701433A EA 200701433 A EA200701433 A EA 200701433A EA 200701433 A1 EA200701433 A1 EA 200701433A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- irbisartana
- receiving
- pharmaceutically acceptable
- irbesartan
- salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Настоящее изобретение относится к способу получения ирбесартана или его фармацевтически приемлемых солей, включающему синтез тритилирбесартана с помощью реакции 5-(4-(бромометил)бифенил-2-ил)-1-(трифенилметил)тетразола и 2-н-бутил-4-циклопентан-2-имидазолин-5-она или его соли в органическом растворителе в присутствии катализатора межфазного переноса и основания, удаление защитной группы и выделение ирбесартана или его фармацевтически приемлемой соли.The present invention relates to a method for producing irbesartan or its pharmaceutically acceptable salts, including the synthesis of tritylrbesartan using the reaction of 5- (4- (bromomethyl) biphenyl-2-yl) -1- (triphenylmethyl) tetrazole and 2-n-butyl-4-cyclopentane -2-imidazolin-5-one or its salt in an organic solvent in the presence of a phase transfer catalyst and a base, removal of the protective group and isolation of irbesartan or its pharmaceutically acceptable salt.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI200500004A SI21964A (en) | 2005-01-05 | 2005-01-05 | Preparation of tetrazole derivative |
SI200500132A SI21965A (en) | 2005-01-05 | 2005-05-05 | Preparation of tetrazole derivative |
PCT/SI2006/000001 WO2006073376A2 (en) | 2005-01-05 | 2006-01-04 | Preparation of irbesartan |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200701433A1 true EA200701433A1 (en) | 2008-02-28 |
EA012852B1 EA012852B1 (en) | 2009-12-30 |
Family
ID=36129763
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200701433A EA012852B1 (en) | 2005-01-05 | 2006-01-04 | Preparation of irbesartan |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP2049527A2 (en) |
EA (1) | EA012852B1 (en) |
NO (1) | NO20073984L (en) |
SI (1) | SI21965A (en) |
WO (1) | WO2006073376A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1916246A3 (en) * | 2006-10-11 | 2008-06-18 | Cadila Pharmaceuticals Limited | An improved process for the preparation of olmesartan medoxomil |
GB0700993D0 (en) * | 2007-01-18 | 2007-02-28 | Rainbow Engineering Services | Novel compounds |
GB0700992D0 (en) * | 2007-01-18 | 2007-02-28 | Rainbow Engineering Services | Novel compounds |
EP2194050A1 (en) | 2008-12-08 | 2010-06-09 | KRKA, tovarna zdravil, d.d., Novo mesto | A new process for the preparation of irbesartan |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE340793T1 (en) * | 2002-07-16 | 2006-10-15 | Teva Pharma | NEW SYNTHESIS OF IRBESARTAN |
CN101165062A (en) * | 2003-01-16 | 2008-04-23 | 特瓦制药工业有限公司 | Novel synthesis of irbesartan |
EP1590343B1 (en) * | 2003-02-05 | 2008-07-16 | Teva Pharmaceutical Industries Limited | Synthesis of 2-butyl-3-(2' -(1-trityl-1h-tetrazol-5-yl)biphen yl-4-yl)-1,3-diazaspiro-4,4 -nonene-4-one |
SI21849A (en) * | 2004-07-29 | 2006-02-28 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Preparation of hydrochloride salts of tetrazole derivative |
-
2005
- 2005-05-05 SI SI200500132A patent/SI21965A/en not_active IP Right Cessation
-
2006
- 2006-01-04 WO PCT/SI2006/000001 patent/WO2006073376A2/en active Application Filing
- 2006-01-04 EP EP06700020A patent/EP2049527A2/en not_active Withdrawn
- 2006-01-04 EA EA200701433A patent/EA012852B1/en not_active IP Right Cessation
-
2007
- 2007-07-31 NO NO20073984A patent/NO20073984L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2006073376A2 (en) | 2006-07-13 |
WO2006073376A3 (en) | 2006-09-21 |
NO20073984L (en) | 2007-10-05 |
SI21965A (en) | 2006-08-31 |
EA012852B1 (en) | 2009-12-30 |
EP2049527A2 (en) | 2009-04-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |