EA200701433A1 - RECEIVING IRBISARTANA - Google Patents

RECEIVING IRBISARTANA

Info

Publication number
EA200701433A1
EA200701433A1 EA200701433A EA200701433A EA200701433A1 EA 200701433 A1 EA200701433 A1 EA 200701433A1 EA 200701433 A EA200701433 A EA 200701433A EA 200701433 A EA200701433 A EA 200701433A EA 200701433 A1 EA200701433 A1 EA 200701433A1
Authority
EA
Eurasian Patent Office
Prior art keywords
irbisartana
receiving
pharmaceutically acceptable
irbesartan
salt
Prior art date
Application number
EA200701433A
Other languages
Russian (ru)
Other versions
EA012852B1 (en
Inventor
Силво Зупанциц
Аница Пецавар
Рок Зупет
Original Assignee
Крка, Товарна Здравил, Д. Д., Ново Место
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SI200500004A external-priority patent/SI21964A/en
Application filed by Крка, Товарна Здравил, Д. Д., Ново Место filed Critical Крка, Товарна Здравил, Д. Д., Ново Место
Publication of EA200701433A1 publication Critical patent/EA200701433A1/en
Publication of EA012852B1 publication Critical patent/EA012852B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Настоящее изобретение относится к способу получения ирбесартана или его фармацевтически приемлемых солей, включающему синтез тритилирбесартана с помощью реакции 5-(4-(бромометил)бифенил-2-ил)-1-(трифенилметил)тетразола и 2-н-бутил-4-циклопентан-2-имидазолин-5-она или его соли в органическом растворителе в присутствии катализатора межфазного переноса и основания, удаление защитной группы и выделение ирбесартана или его фармацевтически приемлемой соли.The present invention relates to a method for producing irbesartan or its pharmaceutically acceptable salts, including the synthesis of tritylrbesartan using the reaction of 5- (4- (bromomethyl) biphenyl-2-yl) -1- (triphenylmethyl) tetrazole and 2-n-butyl-4-cyclopentane -2-imidazolin-5-one or its salt in an organic solvent in the presence of a phase transfer catalyst and a base, removal of the protective group and isolation of irbesartan or its pharmaceutically acceptable salt.

EA200701433A 2005-01-05 2006-01-04 Preparation of irbesartan EA012852B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SI200500004A SI21964A (en) 2005-01-05 2005-01-05 Preparation of tetrazole derivative
SI200500132A SI21965A (en) 2005-01-05 2005-05-05 Preparation of tetrazole derivative
PCT/SI2006/000001 WO2006073376A2 (en) 2005-01-05 2006-01-04 Preparation of irbesartan

Publications (2)

Publication Number Publication Date
EA200701433A1 true EA200701433A1 (en) 2008-02-28
EA012852B1 EA012852B1 (en) 2009-12-30

Family

ID=36129763

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701433A EA012852B1 (en) 2005-01-05 2006-01-04 Preparation of irbesartan

Country Status (5)

Country Link
EP (1) EP2049527A2 (en)
EA (1) EA012852B1 (en)
NO (1) NO20073984L (en)
SI (1) SI21965A (en)
WO (1) WO2006073376A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1916246A3 (en) * 2006-10-11 2008-06-18 Cadila Pharmaceuticals Limited An improved process for the preparation of olmesartan medoxomil
GB0700993D0 (en) * 2007-01-18 2007-02-28 Rainbow Engineering Services Novel compounds
GB0700992D0 (en) * 2007-01-18 2007-02-28 Rainbow Engineering Services Novel compounds
EP2194050A1 (en) 2008-12-08 2010-06-09 KRKA, tovarna zdravil, d.d., Novo mesto A new process for the preparation of irbesartan

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050176794A1 (en) * 2002-07-16 2005-08-11 Ben-Zion Dolitzky Novel synthesis of irbesartan
WO2004065383A2 (en) * 2003-01-16 2004-08-05 Teva Pharmaceutical Industries Ltd. Novel synthesis of irbesartan
ATE401323T1 (en) * 2003-02-05 2008-08-15 Teva Pharma SYNTHESIS OF 2-BUTYL-3-(2'-(1-TRITYL-1H-TETRAZOLE- 5-YL)BIPHENYL-4-YL)-1,3-DIAZASPIRO-4,4 -NONEN-4-ONE
SI21849A (en) * 2004-07-29 2006-02-28 Krka, Tovarna Zdravil, D.D., Novo Mesto Preparation of hydrochloride salts of tetrazole derivative

Also Published As

Publication number Publication date
WO2006073376A3 (en) 2006-09-21
EA012852B1 (en) 2009-12-30
WO2006073376A2 (en) 2006-07-13
NO20073984L (en) 2007-10-05
EP2049527A2 (en) 2009-04-22
SI21965A (en) 2006-08-31

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU