NO20073984L - Preparation of tetrazole derivatives - Google Patents

Preparation of tetrazole derivatives

Info

Publication number
NO20073984L
NO20073984L NO20073984A NO20073984A NO20073984L NO 20073984 L NO20073984 L NO 20073984L NO 20073984 A NO20073984 A NO 20073984A NO 20073984 A NO20073984 A NO 20073984A NO 20073984 L NO20073984 L NO 20073984L
Authority
NO
Norway
Prior art keywords
preparation
irbesartan
pharmaceutically acceptable
tetrazole derivatives
tetrazole
Prior art date
Application number
NO20073984A
Other languages
Norwegian (no)
Inventor
Silvo Zupancic
Anica Pecavar
Rok Zupet
Original Assignee
Krka Tovarna Zdravil Dd Novo M
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SI200500004A external-priority patent/SI21964A/en
Application filed by Krka Tovarna Zdravil Dd Novo M filed Critical Krka Tovarna Zdravil Dd Novo M
Publication of NO20073984L publication Critical patent/NO20073984L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Den foreliggende oppfinnelsen angår en fremgangsmåte for fremstillingen av irbesartan eller dets farmasøytisk akseptable salter, som omfatter en syntese av tritylirbesartan ved en reaksjon mellom 5-(4-brommetyl)bifenyl-2-yl)-1-(trifenylmetyl)tetrazol og 2-n-butyl-4-syklopentan-2-imidazolin-5-on eller et salt av disse, i et organisk løsemiddel i nærvær av en faseoverføringskatalysator og en base, en fjerning av den beskyttende gruppen og en isolering av irbesartan eller dets farmasøytisk akseptable salt.The present invention relates to a process for the preparation of irbesartan or its pharmaceutically acceptable salts, which comprises a synthesis of tritylirbesartan by a reaction of 5- (4-bromomethyl) biphenyl-2-yl) -1- (triphenylmethyl) tetrazole and 2-n. -butyl-4-cyclopentan-2-imidazolin-5-one or a salt thereof, in an organic solvent in the presence of a phase transfer catalyst and a base, a removal of the protecting group and an isolation of irbesartan or its pharmaceutically acceptable salt.

NO20073984A 2005-01-05 2007-07-31 Preparation of tetrazole derivatives NO20073984L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SI200500004A SI21964A (en) 2005-01-05 2005-01-05 Preparation of tetrazole derivative
SI200500132A SI21965A (en) 2005-01-05 2005-05-05 Preparation of tetrazole derivative
PCT/SI2006/000001 WO2006073376A2 (en) 2005-01-05 2006-01-04 Preparation of irbesartan

Publications (1)

Publication Number Publication Date
NO20073984L true NO20073984L (en) 2007-10-05

Family

ID=36129763

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20073984A NO20073984L (en) 2005-01-05 2007-07-31 Preparation of tetrazole derivatives

Country Status (5)

Country Link
EP (1) EP2049527A2 (en)
EA (1) EA012852B1 (en)
NO (1) NO20073984L (en)
SI (1) SI21965A (en)
WO (1) WO2006073376A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1916246A3 (en) * 2006-10-11 2008-06-18 Cadila Pharmaceuticals Limited An improved process for the preparation of olmesartan medoxomil
GB0700993D0 (en) * 2007-01-18 2007-02-28 Rainbow Engineering Services Novel compounds
GB0700992D0 (en) * 2007-01-18 2007-02-28 Rainbow Engineering Services Novel compounds
EP2194050A1 (en) 2008-12-08 2010-06-09 KRKA, tovarna zdravil, d.d., Novo mesto A new process for the preparation of irbesartan

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050176794A1 (en) * 2002-07-16 2005-08-11 Ben-Zion Dolitzky Novel synthesis of irbesartan
WO2004065383A2 (en) * 2003-01-16 2004-08-05 Teva Pharmaceutical Industries Ltd. Novel synthesis of irbesartan
ATE401323T1 (en) * 2003-02-05 2008-08-15 Teva Pharma SYNTHESIS OF 2-BUTYL-3-(2'-(1-TRITYL-1H-TETRAZOLE- 5-YL)BIPHENYL-4-YL)-1,3-DIAZASPIRO-4,4 -NONEN-4-ONE
SI21849A (en) * 2004-07-29 2006-02-28 Krka, Tovarna Zdravil, D.D., Novo Mesto Preparation of hydrochloride salts of tetrazole derivative

Also Published As

Publication number Publication date
WO2006073376A3 (en) 2006-09-21
EA012852B1 (en) 2009-12-30
WO2006073376A2 (en) 2006-07-13
EP2049527A2 (en) 2009-04-22
SI21965A (en) 2006-08-31
EA200701433A1 (en) 2008-02-28

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application