UA88501C2 - Preparation of irbesartan - Google Patents

Preparation of irbesartan

Info

Publication number
UA88501C2
UA88501C2 UAA200708937A UAA200708937A UA88501C2 UA 88501 C2 UA88501 C2 UA 88501C2 UA A200708937 A UAA200708937 A UA A200708937A UA A200708937 A UAA200708937 A UA A200708937A UA 88501 C2 UA88501 C2 UA 88501C2
Authority
UA
Ukraine
Prior art keywords
irbesartan
preparation
pharmaceutically acceptable
salt
imidazolin
Prior art date
Application number
UAA200708937A
Other languages
Russian (ru)
Inventor
Силво Жупанчич
Аника Пекавар
Рок Зупет
Original Assignee
Крка, Товарна Здравил, Д.Д. Ново Место
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Крка, Товарна Здравил, Д.Д. Ново Место filed Critical Крка, Товарна Здравил, Д.Д. Ново Место
Publication of UA88501C2 publication Critical patent/UA88501C2/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to a process for the preparation of irbesartan or its pharmaceutically acceptable salts comprising a synthesis of trityl irbesartan by a reaction of 5-(4-(bromomethyl)biphenyl-2-yl)-l-(triphenylmethyl)tetrazole and 2-n-butyl-4-cyclopentane-2-imidazolin-5-one or a salt therof in an organic solvent in the presence of a phase transfer catalyst and a base, a removal of the protecting group and an isolation of irbesartan or its pharmaceutically acceptable salt.
UAA200708937A 2005-01-05 2006-01-04 Preparation of irbesartan UA88501C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI200500004A SI21964A (en) 2005-01-05 2005-01-05 Preparation of tetrazole derivative

Publications (1)

Publication Number Publication Date
UA88501C2 true UA88501C2 (en) 2009-10-26

Family

ID=36951064

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200708937A UA88501C2 (en) 2005-01-05 2006-01-04 Preparation of irbesartan

Country Status (2)

Country Link
SI (1) SI21964A (en)
UA (1) UA88501C2 (en)

Also Published As

Publication number Publication date
SI21964A (en) 2006-08-31

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