EA200401335A1 - CARBOXIMIDE DERIVATIVES AS UROSELECTIVE ALPHA-1A BLOCKERS OF ADDRESSORCEPTORS - Google Patents

CARBOXIMIDE DERIVATIVES AS UROSELECTIVE ALPHA-1A BLOCKERS OF ADDRESSORCEPTORS

Info

Publication number
EA200401335A1
EA200401335A1 EA200401335A EA200401335A EA200401335A1 EA 200401335 A1 EA200401335 A1 EA 200401335A1 EA 200401335 A EA200401335 A EA 200401335A EA 200401335 A EA200401335 A EA 200401335A EA 200401335 A1 EA200401335 A1 EA 200401335A1
Authority
EA
Eurasian Patent Office
Prior art keywords
addressorceptors
uroselective
blockers
alpha
carboximide derivatives
Prior art date
Application number
EA200401335A
Other languages
Russian (ru)
Inventor
Мохаммад Салман
Гян Чанд Ядав
Сомеш ШАРМА
Гобинд Сингх Капкоти
Анита Чугх
Джанг Бахадур Гупта
Нитья Ананд
Original Assignee
Ранбакси Лабораторис Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ранбакси Лабораторис Лимитед filed Critical Ранбакси Лабораторис Лимитед
Publication of EA200401335A1 publication Critical patent/EA200401335A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Предложены новые производные карбоксимида, которые селективно ингибируют связывание с α-адренорецептором, играющим важную роль в лечении доброкачественной гиперплазии простаты. Соединения по настоящему изобретению являются потенциально пригодными для лечения доброкачественной гиперплазии простаты.Международная заявка была опубликована вместе с отчетом о международном поиске.New carboximide derivatives have been proposed that selectively inhibit the binding to the α-adrenoreceptor, which plays an important role in the treatment of benign prostatic hyperplasia. The compounds of the present invention are potentially useful in treating benign prostatic hyperplasia. The international application was published along with an international search report.

EA200401335A 2002-04-08 2002-04-08 CARBOXIMIDE DERIVATIVES AS UROSELECTIVE ALPHA-1A BLOCKERS OF ADDRESSORCEPTORS EA200401335A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2002/001108 WO2003084541A1 (en) 2002-04-08 2002-04-08 Carboximide derivatives as useful uro-selective alpha-1a adrenoceptor blockers

Publications (1)

Publication Number Publication Date
EA200401335A1 true EA200401335A1 (en) 2006-02-24

Family

ID=28686909

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401335A EA200401335A1 (en) 2002-04-08 2002-04-08 CARBOXIMIDE DERIVATIVES AS UROSELECTIVE ALPHA-1A BLOCKERS OF ADDRESSORCEPTORS

Country Status (8)

Country Link
EP (1) EP1494674A4 (en)
JP (1) JP2005532282A (en)
CN (1) CN1627946A (en)
AU (1) AU2002251409A1 (en)
BR (1) BR0215686A (en)
EA (1) EA200401335A1 (en)
MX (1) MXPA04009821A (en)
WO (1) WO2003084541A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005018643A1 (en) * 2003-08-25 2005-03-03 Ranbaxy Laboratories Limited Metabolites of 1-{3-4`4-(2-methoxyphenyl) piperazin-1-yl!-propyl}-piperidine-2, 6-dione for use in the treatment of benign prostatic hyperplasia
WO2005037281A1 (en) * 2003-10-15 2005-04-28 Ranbaxy Laboratories Limited 1-alkylpiperazinyl-pyrrolidin-2, 5-dione derivatives as adrenergic receptor antagonist

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2188936T3 (en) * 1996-04-05 2003-07-01 Sod Conseils Rech Applic ANTAGONISTS OF THE ALFA-Q-ADRENERGIC RECEIVER.
IT1293807B1 (en) * 1997-08-01 1999-03-10 Recordati Chem Pharm 1- (N-PHENYLAMINOALKYL) PIPERAZINE DERIVATIVES SUBSTITUTED AT POSITION 2 OF THE PHENYL RING
US6083950A (en) * 1997-11-13 2000-07-04 Ranbaxy Laboratories Limited 1-(4-arylpiperazin-1-yl)-ω-[n-(α,ω-dicarboximido)]-alka nes useful as uro-selective α1-adrenoceptor blockers
FR2781220B1 (en) * 1998-07-17 2000-10-13 Lafon Labor SUBSTITUTED BETA PIPERAZINONES

Also Published As

Publication number Publication date
EP1494674A4 (en) 2006-04-12
JP2005532282A (en) 2005-10-27
WO2003084541A1 (en) 2003-10-16
EP1494674A1 (en) 2005-01-12
CN1627946A (en) 2005-06-15
AU2002251409A1 (en) 2003-10-20
BR0215686A (en) 2005-02-22
MXPA04009821A (en) 2004-12-13

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