BR0215686A - Carboximide Derivatives Useful as Uroselective Adrenoceptor (alpha) Blockers 1a - Google Patents
Carboximide Derivatives Useful as Uroselective Adrenoceptor (alpha) Blockers 1aInfo
- Publication number
- BR0215686A BR0215686A BR0215686-5A BR0215686A BR0215686A BR 0215686 A BR0215686 A BR 0215686A BR 0215686 A BR0215686 A BR 0215686A BR 0215686 A BR0215686 A BR 0215686A
- Authority
- BR
- Brazil
- Prior art keywords
- adrenoceptor
- blockers
- uroselective
- alpha
- derivatives useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"DERIVADOS DE CARBOXIMIDA úTEIS COMO BLOQUEADORES DE <244>~ 1A~ADRENOCEPTOR UROSSELETIVO". A presente invenção refere-se a derivados de carboximida que inibem seletivamente a aglutinação no receptor <244>~ 1A~adrenérgico, um receptor que foi mostrado como sendo importante no tratamento de hiperplasia benigna da próstata. Os compostos da presente invenção são potencialmente úteis no tratamento da hiperplasia prostática benigna."CARBOXYMID DERIVATIVES USEFUL AS UREDLECTIVE <244> ~ 1A ~ ADRENOCEPTOR BLOCKERS". The present invention relates to carboximide derivatives that selectively inhibit agglutination at the β-1A-adrenergic receptor, a receptor that has been shown to be important in the treatment of benign prostate hyperplasia. The compounds of the present invention are potentially useful in treating benign prostatic hyperplasia.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2002/001108 WO2003084541A1 (en) | 2002-04-08 | 2002-04-08 | Carboximide derivatives as useful uro-selective alpha-1a adrenoceptor blockers |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0215686A true BR0215686A (en) | 2005-02-22 |
Family
ID=28686909
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0215686-5A BR0215686A (en) | 2002-04-08 | 2002-04-08 | Carboximide Derivatives Useful as Uroselective Adrenoceptor (alpha) Blockers 1a |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1494674A4 (en) |
JP (1) | JP2005532282A (en) |
CN (1) | CN1627946A (en) |
AU (1) | AU2002251409A1 (en) |
BR (1) | BR0215686A (en) |
EA (1) | EA200401335A1 (en) |
MX (1) | MXPA04009821A (en) |
WO (1) | WO2003084541A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005018643A1 (en) * | 2003-08-25 | 2005-03-03 | Ranbaxy Laboratories Limited | Metabolites of 1-{3-4`4-(2-methoxyphenyl) piperazin-1-yl!-propyl}-piperidine-2, 6-dione for use in the treatment of benign prostatic hyperplasia |
WO2005037281A1 (en) * | 2003-10-15 | 2005-04-28 | Ranbaxy Laboratories Limited | 1-alkylpiperazinyl-pyrrolidin-2, 5-dione derivatives as adrenergic receptor antagonist |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ315098A3 (en) * | 1996-04-05 | 1999-04-14 | Société De Conseils De Recherches Et D'applications Scientifiques (S. C. R. A. S.) | Antagonists of alpha1-adrenergic receptors |
IT1293807B1 (en) * | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | 1- (N-PHENYLAMINOALKYL) PIPERAZINE DERIVATIVES SUBSTITUTED AT POSITION 2 OF THE PHENYL RING |
US6083950A (en) * | 1997-11-13 | 2000-07-04 | Ranbaxy Laboratories Limited | 1-(4-arylpiperazin-1-yl)-ω-[n-(α,ω-dicarboximido)]-alka nes useful as uro-selective α1-adrenoceptor blockers |
FR2781220B1 (en) * | 1998-07-17 | 2000-10-13 | Lafon Labor | SUBSTITUTED BETA PIPERAZINONES |
-
2002
- 2002-04-08 AU AU2002251409A patent/AU2002251409A1/en not_active Abandoned
- 2002-04-08 CN CNA028290976A patent/CN1627946A/en active Pending
- 2002-04-08 MX MXPA04009821A patent/MXPA04009821A/en not_active Application Discontinuation
- 2002-04-08 JP JP2003581781A patent/JP2005532282A/en not_active Withdrawn
- 2002-04-08 WO PCT/IB2002/001108 patent/WO2003084541A1/en active Application Filing
- 2002-04-08 BR BR0215686-5A patent/BR0215686A/en not_active IP Right Cessation
- 2002-04-08 EA EA200401335A patent/EA200401335A1/en unknown
- 2002-04-08 EP EP02720343A patent/EP1494674A4/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
MXPA04009821A (en) | 2004-12-13 |
WO2003084541A1 (en) | 2003-10-16 |
EP1494674A1 (en) | 2005-01-12 |
EP1494674A4 (en) | 2006-04-12 |
EA200401335A1 (en) | 2006-02-24 |
JP2005532282A (en) | 2005-10-27 |
CN1627946A (en) | 2005-06-15 |
AU2002251409A1 (en) | 2003-10-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application fees: dismissal - article 86 of industrial property law |
Free format text: REFERENTE A(S) 6A,7A,8A E 9A ANUIDADE(S). |
|
B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011. |