BR0215686A - Carboximide Derivatives Useful as Uroselective Adrenoceptor (alpha) Blockers 1a - Google Patents

Carboximide Derivatives Useful as Uroselective Adrenoceptor (alpha) Blockers 1a

Info

Publication number
BR0215686A
BR0215686A BR0215686-5A BR0215686A BR0215686A BR 0215686 A BR0215686 A BR 0215686A BR 0215686 A BR0215686 A BR 0215686A BR 0215686 A BR0215686 A BR 0215686A
Authority
BR
Brazil
Prior art keywords
adrenoceptor
blockers
uroselective
alpha
derivatives useful
Prior art date
Application number
BR0215686-5A
Other languages
Portuguese (pt)
Inventor
Mohammad Salman
Gyan Chand Yadav
Somesh Sharma
Gobind Singh Kapkoti
Anita Chugh
Jang Bahadur Gupta
Nitya Anand
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of BR0215686A publication Critical patent/BR0215686A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"DERIVADOS DE CARBOXIMIDA úTEIS COMO BLOQUEADORES DE <244>~ 1A~ADRENOCEPTOR UROSSELETIVO". A presente invenção refere-se a derivados de carboximida que inibem seletivamente a aglutinação no receptor <244>~ 1A~adrenérgico, um receptor que foi mostrado como sendo importante no tratamento de hiperplasia benigna da próstata. Os compostos da presente invenção são potencialmente úteis no tratamento da hiperplasia prostática benigna."CARBOXYMID DERIVATIVES USEFUL AS UREDLECTIVE <244> ~ 1A ~ ADRENOCEPTOR BLOCKERS". The present invention relates to carboximide derivatives that selectively inhibit agglutination at the β-1A-adrenergic receptor, a receptor that has been shown to be important in the treatment of benign prostate hyperplasia. The compounds of the present invention are potentially useful in treating benign prostatic hyperplasia.

BR0215686-5A 2002-04-08 2002-04-08 Carboximide Derivatives Useful as Uroselective Adrenoceptor (alpha) Blockers 1a BR0215686A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2002/001108 WO2003084541A1 (en) 2002-04-08 2002-04-08 Carboximide derivatives as useful uro-selective alpha-1a adrenoceptor blockers

Publications (1)

Publication Number Publication Date
BR0215686A true BR0215686A (en) 2005-02-22

Family

ID=28686909

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0215686-5A BR0215686A (en) 2002-04-08 2002-04-08 Carboximide Derivatives Useful as Uroselective Adrenoceptor (alpha) Blockers 1a

Country Status (8)

Country Link
EP (1) EP1494674A4 (en)
JP (1) JP2005532282A (en)
CN (1) CN1627946A (en)
AU (1) AU2002251409A1 (en)
BR (1) BR0215686A (en)
EA (1) EA200401335A1 (en)
MX (1) MXPA04009821A (en)
WO (1) WO2003084541A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003259391A1 (en) * 2003-08-25 2005-03-10 Ranbaxy Laboratories Limited Metabolites of 1-{3-4`4-(2-methoxyphenyl) piperazin-1-yl!-propyl}-piperidine-2, 6-dione for use in the treatment of benign prostatic hyperplasia
WO2005037281A1 (en) * 2003-10-15 2005-04-28 Ranbaxy Laboratories Limited 1-alkylpiperazinyl-pyrrolidin-2, 5-dione derivatives as adrenergic receptor antagonist

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE229946T1 (en) * 1996-04-05 2003-01-15 Sod Conseils Rech Applic ALPHA-1 ADRENERGIC RECEPTOR ANTAGONISTS
IT1293807B1 (en) * 1997-08-01 1999-03-10 Recordati Chem Pharm 1- (N-PHENYLAMINOALKYL) PIPERAZINE DERIVATIVES SUBSTITUTED AT POSITION 2 OF THE PHENYL RING
US6083950A (en) * 1997-11-13 2000-07-04 Ranbaxy Laboratories Limited 1-(4-arylpiperazin-1-yl)-ω-[n-(α,ω-dicarboximido)]-alka nes useful as uro-selective α1-adrenoceptor blockers
FR2781220B1 (en) * 1998-07-17 2000-10-13 Lafon Labor SUBSTITUTED BETA PIPERAZINONES

Also Published As

Publication number Publication date
JP2005532282A (en) 2005-10-27
EP1494674A1 (en) 2005-01-12
EA200401335A1 (en) 2006-02-24
WO2003084541A1 (en) 2003-10-16
AU2002251409A1 (en) 2003-10-20
EP1494674A4 (en) 2006-04-12
MXPA04009821A (en) 2004-12-13
CN1627946A (en) 2005-06-15

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Legal Events

Date Code Title Description
B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE A(S) 6A,7A,8A E 9A ANUIDADE(S).

B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011.