EA200401012A1 - MEDICINAL MEANS OF PROLONGED ACTION IN DEPOT-FORM, MEDIA FOR SUCH MEDICINES AND METHOD OF OBTAINING THEM - Google Patents

MEDICINAL MEANS OF PROLONGED ACTION IN DEPOT-FORM, MEDIA FOR SUCH MEDICINES AND METHOD OF OBTAINING THEM

Info

Publication number
EA200401012A1
EA200401012A1 EA200401012A EA200401012A EA200401012A1 EA 200401012 A1 EA200401012 A1 EA 200401012A1 EA 200401012 A EA200401012 A EA 200401012A EA 200401012 A EA200401012 A EA 200401012A EA 200401012 A1 EA200401012 A1 EA 200401012A1
Authority
EA
Eurasian Patent Office
Prior art keywords
depot
medicines
media
obtaining
carriers
Prior art date
Application number
EA200401012A
Other languages
Russian (ru)
Other versions
EA006988B1 (en
Inventor
Габриеле Райх
Бертхольд Кёлер
Original Assignee
Дойче Желатине-Фабрикен Штёсс Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дойче Желатине-Фабрикен Штёсс Аг filed Critical Дойче Желатине-Фабрикен Штёсс Аг
Publication of EA200401012A1 publication Critical patent/EA200401012A1/en
Publication of EA006988B1 publication Critical patent/EA006988B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Materials For Medical Uses (AREA)
  • Biological Treatment Of Waste Water (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Detergent Compositions (AREA)

Abstract

В заявке описываются лекарственное средство пролонгированного действия в депо-форме с фармакологическим действующим веществом и носителем, предназначенное, прежде всего, для парентерального применения, а также носители для лекарственных средств подобного типа и способ получения таких носителей, при этом обеспечивается точно определенное высвобождение действующего вещества в течение предусмотренного промежутка времени и сохранение его фармакологической эффективности. Предлагаемый в изобретении носитель получают из материала, представляющего собой полимер, образованный из соответствующего полипептида и связанного с ним ковалентной связью биологически разлагаемого сложного полиэфира.Международная заявка была опубликована вместе с отчетом о международном поиске.The application describes a sustained-release drug in a depot form with a pharmacological active substance and a carrier, intended primarily for parenteral use, as well as carriers for drugs of this type and a method for producing such carriers, while ensuring precisely defined release of the active substance during the prescribed period of time and maintaining its pharmacological efficacy. The carrier according to the invention is obtained from a material which is a polymer formed from the corresponding polypeptide and the associated covalent bond of a biodegradable polyester. The international application was published together with an international search report.

EA200401012A 2002-02-16 2003-01-24 Depot medicament, carrier materials for depot medicaments, and method for the production thereof EA006988B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10206517A DE10206517A1 (en) 2002-02-16 2002-02-16 Depot medicinal products, carrier materials for depot medicinal products and processes for their production
PCT/EP2003/000725 WO2003068192A1 (en) 2002-02-16 2003-01-24 Depot medicament, carrier materials for depot medicaments, and method for the production thereof

Publications (2)

Publication Number Publication Date
EA200401012A1 true EA200401012A1 (en) 2005-04-28
EA006988B1 EA006988B1 (en) 2006-06-30

Family

ID=27674694

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401012A EA006988B1 (en) 2002-02-16 2003-01-24 Depot medicament, carrier materials for depot medicaments, and method for the production thereof

Country Status (17)

Country Link
EP (1) EP1474110B1 (en)
AT (1) ATE369123T1 (en)
AU (1) AU2003210181A1 (en)
BR (1) BR0307675A (en)
DE (2) DE10206517A1 (en)
DK (1) DK1474110T3 (en)
EA (1) EA006988B1 (en)
ES (1) ES2289304T3 (en)
HU (1) HUP0500119A3 (en)
IL (2) IL162868A0 (en)
MX (1) MXPA04006982A (en)
NO (1) NO20043860L (en)
NZ (1) NZ533103A (en)
PL (1) PL371785A1 (en)
PT (1) PT1474110E (en)
WO (1) WO2003068192A1 (en)
ZA (1) ZA200403979B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20060682A1 (en) * 2006-12-19 2008-06-20 Sicit Chemitech S P A NEW BIODEGRADABLE POLYMER DERIVATIVES
DE102007011606A1 (en) 2007-03-02 2008-09-04 Carl Freudenberg Kg Fiber-tangled structure useful as cell settling material, wound covering, medical implant and carriers for pharmaceutical active substance and for producing depot medicament, comprises fibers made of partially interlaced gelatin material

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2046830C (en) * 1990-07-19 1999-12-14 Patrick P. Deluca Drug delivery system involving inter-action between protein or polypeptide and hydrophobic biodegradable polymer
GB9211268D0 (en) * 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
DK0814778T3 (en) * 1995-03-10 2001-09-17 Roche Diagnostics Gmbh Polypeptide-containing pharmaceutical administration forms in the form of microparticles and their method of preparation
DE19813174A1 (en) * 1998-03-25 1999-05-27 Schering Ag Gas-filled microparticles, used for administering biologically active substances
CA2370357C (en) * 1999-04-16 2007-04-10 Wm. Marsh Rice University Poly(propylene fumarate) cross linked with poly(ethylene glycol)

Also Published As

Publication number Publication date
WO2003068192A1 (en) 2003-08-21
EP1474110B1 (en) 2007-08-08
BR0307675A (en) 2005-01-11
ZA200403979B (en) 2004-11-29
PT1474110E (en) 2007-10-01
HUP0500119A3 (en) 2008-04-28
ES2289304T3 (en) 2008-02-01
EP1474110A1 (en) 2004-11-10
ATE369123T1 (en) 2007-08-15
IL162868A (en) 2008-03-20
MXPA04006982A (en) 2004-11-10
DE10206517A1 (en) 2003-09-04
EA006988B1 (en) 2006-06-30
NO20043860L (en) 2004-09-15
DE50307874D1 (en) 2007-09-20
NZ533103A (en) 2007-04-27
IL162868A0 (en) 2005-11-20
HUP0500119A2 (en) 2005-07-28
AU2003210181A1 (en) 2003-09-04
DK1474110T3 (en) 2007-12-10
PL371785A1 (en) 2005-06-27

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU