RU2001132140A - Recombinant platelet collagen receptor glycoprotein VI and its use in pharmaceuticals - Google Patents

Recombinant platelet collagen receptor glycoprotein VI and its use in pharmaceuticals

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Publication number
RU2001132140A
RU2001132140A RU2001132140/13A RU2001132140A RU2001132140A RU 2001132140 A RU2001132140 A RU 2001132140A RU 2001132140/13 A RU2001132140/13 A RU 2001132140/13A RU 2001132140 A RU2001132140 A RU 2001132140A RU 2001132140 A RU2001132140 A RU 2001132140A
Authority
RU
Russia
Prior art keywords
sequence shown
glycoprotein
platelet
recombinant
gpvi
Prior art date
Application number
RU2001132140/13A
Other languages
Russian (ru)
Other versions
RU2287580C2 (en
Inventor
Кеннет Дж. КЛЕМЕТСОН
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of RU2001132140A publication Critical patent/RU2001132140A/en
Application granted granted Critical
Publication of RU2287580C2 publication Critical patent/RU2287580C2/en

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Claims (10)

1. ДНК, кодирующая Гликопротеин VI или его биологически активные фрагменты.1. DNA encoding Glycoprotein VI or its biologically active fragments. 2. ДНК по п.1, которая частично или полностью содержит последовательность, представленную на фиг.2.2. DNA according to claim 1, which partially or completely contains the sequence shown in figure 2. 3. ДНК, которая имеет последовательность, представленную на фиг.2.3. DNA, which has the sequence shown in figure 2. 4. ДНК по пп.1-3, которая кодирует Гликопротеин VI, содержащий аминокислотную последовательность, представленную на фиг.1а и 1b.4. DNA according to claims 1 to 3, which encodes a Glycoprotein VI containing the amino acid sequence shown in figa and 1b. 5. Рекомбинантный человеческий Гликопротеин VI как медицинский препарат, содержащий аминокислотную последовательность, представленную на фиг.1b.5. Recombinant human Glycoprotein VI as a medicine containing the amino acid sequence shown in fig.1b. 6. Фармацевтическая композиция, включающая протеин по п.5 и фармацевтически приемлемые растворитель, носитель или их эксципиенты.6. A pharmaceutical composition comprising the protein of claim 5 and a pharmaceutically acceptable solvent, carrier, or excipients thereof. 7. Фармацевтическая композиция, включающая дополнительно фармакологически активное соединение.7. A pharmaceutical composition, further comprising a pharmacologically active compound. 8. Применение рекомбинантного GPVI в качестве инструмента скрининга на предмет определения специфических ингибиторов взаимодействий тромбоцитов с коллагеном.8. The use of recombinant GPVI as a screening tool for the determination of specific inhibitors of the interaction of platelets with collagen. 9. Применение рекомбинантного GPVI для производства медицинского препарата для терапии тромбозов, сердечно-сосудистых заболеваний и расстройств, связанных с тромбоцит-коллагеновыми взаимодействиями.9. The use of recombinant GPVI for the manufacture of a medicament for the treatment of thrombosis, cardiovascular diseases and disorders associated with platelet-collagen interactions. 10. Применение изменений в GPVI в качестве показателя возраста тромбоцита и воздействия тромбоцита на условия протекания тромбозов и сердечнососудистых заболеваний или приступов.10. Application of changes in GPVI as an indicator of platelet age and the effect of platelet on the course of thrombosis and cardiovascular disease or seizures.
RU2001132140/13A 1999-05-07 2000-04-25 Glycoprotein vi as collagen recombinant receptor on platelets and its using in pharmaceutics RU2287580C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99109094.5 1999-05-07
EP99109094 1999-05-07

Publications (2)

Publication Number Publication Date
RU2001132140A true RU2001132140A (en) 2003-08-10
RU2287580C2 RU2287580C2 (en) 2006-11-20

Family

ID=8238132

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2001132140/13A RU2287580C2 (en) 1999-05-07 2000-04-25 Glycoprotein vi as collagen recombinant receptor on platelets and its using in pharmaceutics

Country Status (26)

Country Link
US (5) US7928066B1 (en)
EP (3) EP1942186B1 (en)
JP (2) JP5480457B2 (en)
KR (1) KR100703592B1 (en)
CN (1) CN1253569C (en)
AR (1) AR023848A1 (en)
AT (1) ATE393223T1 (en)
AU (1) AU775952B2 (en)
BR (1) BRPI0010325B1 (en)
CA (1) CA2372515C (en)
CY (2) CY1108190T1 (en)
CZ (1) CZ302693B6 (en)
DE (1) DE60038675T2 (en)
DK (2) DK1177289T3 (en)
ES (2) ES2534652T3 (en)
HK (1) HK1045714B (en)
HU (1) HUP0201049A2 (en)
MX (1) MXPA01011274A (en)
NO (1) NO333408B1 (en)
PL (1) PL204449B1 (en)
PT (2) PT2341141E (en)
RU (1) RU2287580C2 (en)
SI (1) SI1177289T1 (en)
SK (1) SK15762001A3 (en)
WO (1) WO2000068377A1 (en)
ZA (1) ZA200110071B (en)

Families Citing this family (17)

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Publication number Priority date Publication date Assignee Title
SK15762001A3 (en) 1999-05-07 2002-04-04 Merck Patent Gmbh Recombinant platelet collagen receptor glycoprotein vi and its pharmaceutical use
US7291714B1 (en) 1999-06-30 2007-11-06 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
US6245527B1 (en) 1999-06-30 2001-06-12 Millennium Pharmaceuticals, Inc. Nucleic acid molecules encoding glycoprotein VI and recombinant uses thereof
US20040001826A1 (en) 1999-06-30 2004-01-01 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
AU7097400A (en) * 1999-09-01 2001-03-26 Otsuka Pharmaceutical Co., Ltd. Platelet membrane glycoprotein vi (gpvi) dna and protein sequences, and uses thereof
EP1224942A1 (en) * 2001-01-23 2002-07-24 Bernhard Dr. Nieswandt Use of JAQ1 (monoclonal antibody anti GPVI) as a medicament for the protection against thrombotic diseases
EP1406929A2 (en) * 2001-07-18 2004-04-14 MERCK PATENT GmbH Glycoprotein vi fusion proteins
US7531178B2 (en) 2002-06-07 2009-05-12 Trigen Gmbh Immunoadhesin comprising a glycoprotein VI domain
EP1369128A1 (en) 2002-06-07 2003-12-10 Procorde GmbH Inhibitors of glycoprotein VI and their therapeutic use
US20070071744A1 (en) 2002-06-07 2007-03-29 Gotz Munch Agents which bind to epitopes of glycoprotein VI
DE102004017295A1 (en) * 2004-04-05 2005-11-03 Zlb Behring Gmbh Compounds which cause or prevent the removal of receptors from cell membranes, and methods for their detection
CN1964990B (en) 2004-04-29 2012-12-12 大冢制药株式会社 Antibodies specific for glycoprotein VI and methods of producing these antibodies
US7645592B2 (en) 2004-04-29 2010-01-12 Otsuka Pharmaceutical Co., Ltd. Glycoprotein VI antibodies and methods of use thereof
WO2006117910A1 (en) 2005-04-28 2006-11-09 Mochida Pharmaceutical Co., Ltd. Monoclonal antibody against platelet membrane glycoprotein vi
RU2010121878A (en) * 2007-10-31 2011-12-10 Оцука Фармасьютикал Ко., Лтд. (Jp) Glycoprotein VI Inhibitor (GPVI)
EP2694709B1 (en) 2011-04-08 2016-09-14 Prognosys Biosciences, Inc. Peptide constructs and assay systems
EP3184544A1 (en) * 2015-12-23 2017-06-28 Julius-Maximilians-Universität Würzburg Glycoprotein v inhibitors for use as coagulants

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT662088E (en) 1993-07-01 2002-06-28 Merck Patent Gmbh INHIBITOR OF COLLAGENIC STIMULATED PLATELETS AGGREGATION
AU701576B2 (en) * 1993-10-22 1999-02-04 Trigen Limited Platelet-derived growth factor analogues
AU5927398A (en) * 1997-01-21 1998-08-07 Human Genome Sciences, Inc. Fc receptors and polypeptides
CA2250291A1 (en) * 1997-01-29 1998-07-30 Toray Industries Inc. Chimeric proteins, their heterodimer complexes, and platelet substitutes
SK15762001A3 (en) 1999-05-07 2002-04-04 Merck Patent Gmbh Recombinant platelet collagen receptor glycoprotein vi and its pharmaceutical use
US7291714B1 (en) * 1999-06-30 2007-11-06 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
US20040001826A1 (en) 1999-06-30 2004-01-01 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
US6245527B1 (en) * 1999-06-30 2001-06-12 Millennium Pharmaceuticals, Inc. Nucleic acid molecules encoding glycoprotein VI and recombinant uses thereof
AU7097400A (en) * 1999-09-01 2001-03-26 Otsuka Pharmaceutical Co., Ltd. Platelet membrane glycoprotein vi (gpvi) dna and protein sequences, and uses thereof
EP1406929A2 (en) 2001-07-18 2004-04-14 MERCK PATENT GmbH Glycoprotein vi fusion proteins
EP1538165A1 (en) 2003-12-03 2005-06-08 Procorde GmbH Inhibitors of glycoprotein VI based on monoclonal antibody hgp 5c4

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