EA200400729A1 - НОВЫЕ СОЕДИНЕНИЯ БЕНЗО[α]ПИРАНО[3,2-h]АКРИДИН-7-ОНА, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ИХ - Google Patents

НОВЫЕ СОЕДИНЕНИЯ БЕНЗО[α]ПИРАНО[3,2-h]АКРИДИН-7-ОНА, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ИХ

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Publication number
EA200400729A1
EA200400729A1 EA200400729A EA200400729A EA200400729A1 EA 200400729 A1 EA200400729 A1 EA 200400729A1 EA 200400729 A EA200400729 A EA 200400729A EA 200400729 A EA200400729 A EA 200400729A EA 200400729 A1 EA200400729 A1 EA 200400729A1
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EA
Eurasian Patent Office
Prior art keywords
group
pirano
acridin
description
production
Prior art date
Application number
EA200400729A
Other languages
English (en)
Other versions
EA007790B1 (ru
Inventor
Мишель Кох
Франсуа Тилликен
Сильви Мишель
Джон Хикман
Ален Пьер
Стефан Леонс
Брюно Пфеффер
Пьер Ренар
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA200400729A1 publication Critical patent/EA200400729A1/ru
Publication of EA007790B1 publication Critical patent/EA007790B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Соединения формулы (I)в которой X и Y представляют группу, выбранную из водорода, галогена, гидрокси, алкокси, нитро, циано, алкила, тригалогеналкила и NRR, где Rи Rпринимают значения, указанные в описании,Rпредставляет собой атом водорода или алкильную группу,Rпредставляет собой группу, выбранную из атома водорода и алкильной группы; -OR"; -NR'R'; -O-T-OR"; -NR"-T-NR'R'; -NR"-C(O)-TH; -O-C(O)-TH; -O-T-NR'R'; -NR"-T-OR"; -NR"-T-COR"; и -NR"-C(O)-T-NR'R'групп, где R', R", R'и Tпринимают значения, указанные в описании,Rи Rпредставляют собой атом водорода или алкильную группу,A представляет собой группу формулы -CH(R)-CH(R)-, -CH=C(R)-, -C(R)=CH-, -C(O)-CH(R) или -CH(R)-C(O), где R, R, Rи Rпринимают значения, указанные в описании, их изомеры, указанные в описании, их N-оксиды и их соли присоединения с фармацевтически приемлемой кислотой или основанием. Лекарственные средства.
EA200400729A 2003-06-25 2004-06-24 СОЕДИНЕНИЯ БЕНЗО [α]ПИРАНО[3,2-h]АКРИДИН-7-ОНА И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ИХ EA007790B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0307664A FR2856687B1 (fr) 2003-06-25 2003-06-25 Nouveaux derives de benzo[a]pyrano[3,2-h]acridin-7-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
EA200400729A1 true EA200400729A1 (ru) 2004-12-30
EA007790B1 EA007790B1 (ru) 2007-02-27

Family

ID=33396845

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400729A EA007790B1 (ru) 2003-06-25 2004-06-24 СОЕДИНЕНИЯ БЕНЗО [α]ПИРАНО[3,2-h]АКРИДИН-7-ОНА И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ИХ

Country Status (19)

Country Link
US (1) US7276512B2 (ru)
EP (1) EP1491544A1 (ru)
JP (1) JP2005041864A (ru)
KR (1) KR20050001451A (ru)
CN (1) CN1289502C (ru)
AR (1) AR045695A1 (ru)
AU (1) AU2004202864A1 (ru)
BR (1) BRPI0402500A (ru)
CA (1) CA2472294A1 (ru)
EA (1) EA007790B1 (ru)
FR (1) FR2856687B1 (ru)
GE (1) GEP20063874B (ru)
HK (1) HK1070360A1 (ru)
MA (1) MA27096A1 (ru)
MX (1) MXPA04006177A (ru)
NO (1) NO20042447L (ru)
NZ (1) NZ533747A (ru)
SG (1) SG146431A1 (ru)
ZA (1) ZA200405074B (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2666356C2 (ru) * 2013-04-29 2018-09-07 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Новые производные морфолинилантрациклина

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2986202C (en) * 2015-04-27 2023-08-22 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Egr1 targeting molecules for the treatment of inflammatory and hyperproliferative conditions
CN110105318B (zh) * 2019-06-21 2021-04-09 南京林业大学 一种α-吡喃酮类化合物的绿色合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732204A (en) * 1967-07-17 1973-05-08 Lilly Co Eli Synthesis of acronycine and related compounds
US3943137A (en) * 1973-07-09 1976-03-09 University Of Kansas Endowment Association Acronycine derivatives
GB9318935D0 (en) * 1992-10-20 1993-10-27 Zeneca Ltd Heterocyclic derivatives
US5428040A (en) * 1993-08-31 1995-06-27 The Du Pont Merck Pharmaceutical Company Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents
FR2716197B1 (fr) * 1994-02-17 1996-04-19 Adir Nouveaux analogues de l'acronycine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2772765B1 (fr) * 1997-12-19 2000-03-17 Adir Nouveaux derives de l'acronycine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2795071B1 (fr) * 1999-06-16 2001-07-27 Adir Nouveaux derives de carboxylate de 7-oxo-2,3,7,14- tetrahydro-1h-benzo[b]pyrano[3,2,h] acridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2827864B1 (fr) * 2001-07-25 2005-09-16 Servier Lab Nouveaux derives de benzo[b]pyrano[3,2-h]acridin-7-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2666356C2 (ru) * 2013-04-29 2018-09-07 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Новые производные морфолинилантрациклина

Also Published As

Publication number Publication date
AU2004202864A1 (en) 2005-01-13
SG146431A1 (en) 2008-10-30
EP1491544A1 (fr) 2004-12-29
MA27096A1 (fr) 2004-12-20
CA2472294A1 (fr) 2004-12-25
ZA200405074B (en) 2005-06-02
FR2856687A1 (fr) 2004-12-31
NZ533747A (en) 2005-12-23
CN1576277A (zh) 2005-02-09
US20040266753A1 (en) 2004-12-30
NO20042447L (no) 2004-12-27
HK1070360A1 (en) 2005-06-17
AR045695A1 (es) 2005-11-09
CN1289502C (zh) 2006-12-13
JP2005041864A (ja) 2005-02-17
MXPA04006177A (es) 2005-03-23
GEP20063874B (en) 2006-07-10
FR2856687B1 (fr) 2005-09-16
EA007790B1 (ru) 2007-02-27
KR20050001451A (ko) 2005-01-06
BRPI0402500A (pt) 2005-06-14
US7276512B2 (en) 2007-10-02

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU