EA200200738A1 - Способ и состав для лечения невосприимчивости организма к гипотензивным средствам и связанных с ней состояний - Google Patents

Способ и состав для лечения невосприимчивости организма к гипотензивным средствам и связанных с ней состояний

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Publication number
EA200200738A1
EA200200738A1 EA200200738A EA200200738A EA200200738A1 EA 200200738 A1 EA200200738 A1 EA 200200738A1 EA 200200738 A EA200200738 A EA 200200738A EA 200200738 A EA200200738 A EA 200200738A EA 200200738 A1 EA200200738 A1 EA 200200738A1
Authority
EA
Eurasian Patent Office
Prior art keywords
melatonin
patient
absence
blood pressure
impersibility
Prior art date
Application number
EA200200738A
Other languages
English (en)
Other versions
EA004679B1 (ru
Inventor
Нава Цисапель
Моше Лаудон
Original Assignee
Неурим Фармасьютикалс (1991) Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Неурим Фармасьютикалс (1991) Лтд. filed Critical Неурим Фармасьютикалс (1991) Лтд.
Publication of EA200200738A1 publication Critical patent/EA200200738A1/ru
Publication of EA004679B1 publication Critical patent/EA004679B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Изобретение относится к фармацевтическому составу, содержащему как мелатонин, так и, по меньшей мере, одно гипотензивное соединение, а также к способу лечения пациента с невосприимчивостью к гипотензивным медикаментам в отсутствии мелатонина, способу понижения ночного кровяного давления у пациентов с ненормальным ритмом кровяного давления в отсутствие или присутствии гипотензивных медикаментов и к способу оказания на пациента, по меньшей мере, одного воздействия, выбираемого из улучшения настроения и дневной бессонницы, смещения на более позднее время пикового уровня кортизола у пациента и потенциальной профилактической защиты от разрушительных воздействий ишемии на сердце, в которых мелатонин вводится эффективным способом в эффективных количествах.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200738A 2000-01-05 2000-01-05 Применение и состав для лечения невосприимчивости организма к гипотензивным средствам и связанных с ней состояний EA004679B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IL2000/000009 WO2001049286A1 (en) 2000-01-05 2000-01-05 Method and formulation for treating resistance to antihypertensives and related conditions

Publications (2)

Publication Number Publication Date
EA200200738A1 true EA200200738A1 (ru) 2002-12-26
EA004679B1 EA004679B1 (ru) 2004-06-24

Family

ID=11042938

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200738A EA004679B1 (ru) 2000-01-05 2000-01-05 Применение и состав для лечения невосприимчивости организма к гипотензивным средствам и связанных с ней состояний

Country Status (31)

Country Link
US (3) US7332177B1 (ru)
EP (1) EP1272177B1 (ru)
JP (1) JP4996803B2 (ru)
CN (1) CN1414851A (ru)
AT (1) ATE359072T1 (ru)
AU (1) AU782266B2 (ru)
BG (1) BG65637B1 (ru)
BR (1) BR0016918A (ru)
CA (1) CA2396129C (ru)
CY (2) CY1108018T1 (ru)
CZ (1) CZ299931B6 (ru)
DE (1) DE60034373T2 (ru)
DK (1) DK1272177T3 (ru)
EA (1) EA004679B1 (ru)
EE (1) EE200200379A (ru)
ES (1) ES2284471T3 (ru)
HK (1) HK1052655A1 (ru)
HU (1) HU227002B1 (ru)
IL (1) IL150190A0 (ru)
IS (1) IS6439A (ru)
MX (1) MXPA02005783A (ru)
NO (1) NO322567B1 (ru)
NZ (1) NZ520078A (ru)
PL (1) PL201219B1 (ru)
PT (1) PT1272177E (ru)
SI (1) SI1272177T1 (ru)
SK (1) SK287508B6 (ru)
TR (1) TR200201724T2 (ru)
TW (1) TWI260983B (ru)
UA (1) UA77394C2 (ru)
WO (1) WO2001049286A1 (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL144900A (en) * 2001-08-14 2013-12-31 Neurim Pharma 1991 Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs
US9119846B2 (en) 2003-04-29 2015-09-01 Neurim Pharmaceuticals (1991) Ltd. Method and composition for enhancing cognition in alzheimer's patients
IL155666A (en) 2003-04-29 2013-12-31 Neurim Pharma 1991 Insomnia treatment
US20050020666A1 (en) * 2003-07-25 2005-01-27 Dabur Research Foundation Cardioprotective agents
US20050137247A1 (en) * 2003-12-22 2005-06-23 The Brigham And Women's Hospital, Inc. Methods and compositions for treatment of hypertension
JP3964417B2 (ja) * 2004-09-27 2007-08-22 国立大学法人金沢大学 インドール誘導体を有効成分とするα２受容体遮断剤及び血管拡張剤
KR101053780B1 (ko) * 2008-02-29 2011-08-02 동아제약주식회사 도세탁셀을 함유하는 단일액상의 안정한 약제학적 조성물
US20130325151A1 (en) * 2010-10-25 2013-12-05 Uico, Llc Control system with solid state touch sensor for complex surface geometry
US9532952B2 (en) 2011-01-28 2017-01-03 Physician's Seal, LLC Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients
US8691275B2 (en) 2011-01-28 2014-04-08 Zx Pharma, Llc Controlled-release melatonin compositions and related methods
WO2018033546A1 (en) * 2016-08-18 2018-02-22 Koninklijke Philips N.V. Blood-pressure management
HUE051362T2 (hu) 2016-10-31 2021-03-01 Neurim Pharma 1991 Melatonin minitabletták és eljárás azok elõállítására
US10849856B2 (en) 2016-10-31 2020-12-01 Neurim Pharmaceuticals Ltd. Melatonin mini-tablets and method of manufacturing the same
WO2019038586A1 (en) 2017-08-19 2019-02-28 Ftf Pharma Private Limited PHARMACEUTICAL COMPOSITION OF MELATONIN
ES2724933A1 (es) * 2018-03-13 2019-09-17 Ocupharm Diagnostics Sl Terapia combinada con melatonina para la reducción de la presión intraocular
GB2617102A (en) * 2022-03-29 2023-10-04 John Hemming Trading Ltd Sleep therapy

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0518468B1 (en) 1991-05-09 1999-06-30 Neurim Pharmaceuticals (1991) Limited Melatonin containing compositions
US5508039A (en) 1991-10-18 1996-04-16 Alza Corporation Controlled transdermal administration of melatonin
US5646049A (en) * 1992-03-27 1997-07-08 Abbott Laboratories Scheduling operation of an automated analytical system
DK0565296T3 (da) * 1992-04-07 1996-12-09 Neurim Pharma 1991 Anvendelse af melatonin til fremstilling af et lægemiddel til behandling af godartet prostatahyperplasi
EP0664339A4 (en) * 1993-07-09 1999-04-28 Wakunaga Seiyaku Kk METHOD FOR DISCRIMINATION OF NUCLEIC ACIDS AND TEST KIT FOR THIS PURPOSE.
SK284521B6 (sk) 1995-02-01 2005-05-05 Neurim Pharmaceuticals (1991) Ltd. Použitie melatonínu na prípravu farmaceutického prostriedku
US5648727A (en) * 1995-10-24 1997-07-15 Dpc Cirrus Inc. Capacitive level sensing pipette probe
US5700828A (en) * 1995-12-07 1997-12-23 Life Resuscitation Technologies, Inc. Treatment or prevention of anoxic or ischemic brain injury with melatonin-containing compositions
WO1997037670A1 (en) * 1996-04-10 1997-10-16 Chronorx, Llc Unit dosage forms, containing magnesium, vitamin c, vitamin e, folate and selenium, for treatment of vasoconstriction and related conditions
RU2134108C1 (ru) 1998-10-06 1999-08-10 Заславская Рина Михайловна Средство для лечения артериальной гипертонии, способ лечения артериальной гипертонии

Also Published As

Publication number Publication date
BG106978A (en) 2003-03-31
HU227002B1 (en) 2010-04-28
CN1414851A (zh) 2003-04-30
WO2001049286A1 (en) 2001-07-12
BR0016918A (pt) 2004-03-23
CZ20022346A3 (cs) 2002-11-13
NO20023102D0 (no) 2002-06-27
CY2007033I1 (el) 2009-11-04
TR200201724T2 (tr) 2003-03-21
CA2396129A1 (en) 2001-07-12
DE60034373D1 (de) 2007-05-24
CY1108018T1 (el) 2011-04-06
PT1272177E (pt) 2007-07-11
SK287508B6 (sk) 2010-12-07
IS6439A (is) 2002-06-24
AU782266B2 (en) 2005-07-14
CZ299931B6 (cs) 2008-12-29
CA2396129C (en) 2010-11-30
CY2007033I2 (el) 2009-11-04
JP4996803B2 (ja) 2012-08-08
US20120070501A1 (en) 2012-03-22
EP1272177A1 (en) 2003-01-08
ES2284471T3 (es) 2007-11-16
EE200200379A (et) 2003-10-15
AU1888200A (en) 2001-07-16
NO20023102L (no) 2002-08-30
DK1272177T3 (da) 2007-08-06
EA004679B1 (ru) 2004-06-24
MXPA02005783A (es) 2003-10-14
PL201219B1 (pl) 2009-03-31
DE60034373T2 (de) 2007-12-20
NO322567B1 (no) 2006-10-30
US8075914B2 (en) 2011-12-13
SI1272177T1 (sl) 2007-10-31
PL356325A1 (en) 2004-06-28
HUP0204089A3 (en) 2005-12-28
ATE359072T1 (de) 2007-05-15
UA77394C2 (ru) 2006-12-15
BG65637B1 (bg) 2009-04-30
HK1052655A1 (zh) 2003-09-26
TWI260983B (en) 2006-09-01
IL150190A0 (en) 2002-12-01
JP2003519181A (ja) 2003-06-17
EP1272177B1 (en) 2007-04-11
US7332177B1 (en) 2008-02-19
NZ520078A (en) 2004-02-27
SK9732002A3 (en) 2002-11-06
US8728511B2 (en) 2014-05-20
US20080085317A1 (en) 2008-04-10
HUP0204089A2 (hu) 2003-04-28
EP1272177A4 (en) 2004-04-28

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