EA199801066A1 - INFUSION SOLUTION "REAMBERIN" - Google Patents
INFUSION SOLUTION "REAMBERIN"Info
- Publication number
- EA199801066A1 EA199801066A1 EA199801066A EA199801066A EA199801066A1 EA 199801066 A1 EA199801066 A1 EA 199801066A1 EA 199801066 A EA199801066 A EA 199801066A EA 199801066 A EA199801066 A EA 199801066A EA 199801066 A1 EA199801066 A1 EA 199801066A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- solution
- detoxifying
- infusion solution
- sodium
- antioxidant
- Prior art date
Links
Abstract
Изобретение относится к медицине, а именно к инфузионным солевым растворам, обладающим детоксицирующими свойствами за счет проявления антигипоксических, антиоксидантных и гепатопротекторных свойств. Задачей изобретения является создание детоксицирующего солевого инфузионного раствора, обладающего высокой антигипоксической, антиоксидантной и гепатопротекторной активностью при низкой токсичности и имеющего осмолярность, близкую к осмолярности плазмы крови. Решение поставленной задачи достигается получением детоксицирующего инфузионного раствора на основе нового активного компонента - натрия глюкамина сукцината общей формулы:Na[НОСН(СНОН)СНNHСН][ООС СНСНСОО],образующегося непосредственно в растворе из янтарной кислоты, едкого натра и N-метилглюкамина и содержащего (мас.%): 0,4-0,6 хлорида натрия, 0,011-0,013 хлорида магния, 0,027-0,033 хлорида калия, 1,4-1,6 натрия глюкамина сукцината, остальное - вода для инъекций. Заявляемый инфузионный раствор в процессе детоксикации организма позволяет не только нормализовать водно-электролитный баланс, но и существенно снизить гипоксию органов и тканей, а также усилить выделение токсинов клетками печени (гепатопротекторная активность). Кроме того, заявляемый препарат обладает выраженным антиоксидантным действием, защищая мембраны клеток организма от свободно-радикальных частиц, возникающих в процессе интоксикации.The invention relates to medicine, namely to infusion salt solutions with detoxifying properties due to the manifestation of antihypoxic, antioxidant and hepatoprotective properties. The objective of the invention is the creation of a detoxifying salt infusion solution with high antihypoxic, antioxidant and hepatoprotective activity with low toxicity and having an osmolarity close to the osmolarity of the blood plasma. The solution of this task is achieved by obtaining a detoxifying infusion solution based on a new active component — sodium glucamine succinate of the general formula: Na [НОСН (СНОН) СНННСН] [ООС СНССОО]], which is formed directly in a solution of succinic acid, caustic soda and N-methylglucamine and containing ( wt.%): 0.4–0.6 sodium chloride, 0.011–0.013 magnesium chloride, 0.027–0.033 potassium chloride, 1.4–1.6 sodium glucamine succinate, the rest is water for injection. The inventive infusion solution in the process of detoxification of the body allows not only to normalize water and electrolyte balance, but also significantly reduce the hypoxia of organs and tissues, as well as enhance the release of toxins by liver cells (hepatoprotective activity). In addition, the claimed drug has a pronounced antioxidant effect, protecting the cell membranes of the body from free-radical particles that occur during intoxication.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EA199801066A EA000879B1 (en) | 1998-12-02 | 1998-12-02 | Infusion solution ''reamberin'' |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EA199801066A EA000879B1 (en) | 1998-12-02 | 1998-12-02 | Infusion solution ''reamberin'' |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA199801066A1 true EA199801066A1 (en) | 1999-06-24 |
| EA000879B1 EA000879B1 (en) | 2000-06-26 |
Family
ID=8161471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA199801066A EA000879B1 (en) | 1998-12-02 | 1998-12-02 | Infusion solution ''reamberin'' |
Country Status (1)
| Country | Link |
|---|---|
| EA (1) | EA000879B1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2677856C2 (en) * | 2014-04-29 | 2019-01-22 | Гуменюк Мыкола Ивановыч | Pharmaceutical composition for treatment of chronic obstructive lung diseases |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA007865B1 (en) * | 2005-03-01 | 2007-02-27 | Общество С Ограниченной Ответственностью "Палисандр" | Disintoxicating infusion solution |
| RU2475234C2 (en) * | 2011-05-10 | 2013-02-20 | Олеся Викторовна Спинева | Method for prevention of severe complications accompanying surgical management of massive and submassive blood loss with continuous haemorrhages |
| RU2549448C1 (en) * | 2014-05-20 | 2015-04-27 | Екофарм Патент Менеджмент Аг | Balanced infusion solution |
| RU2621875C1 (en) * | 2016-05-11 | 2017-06-07 | федеральное государственное бюджетное образовательное учреждение высшего образования "Ростовский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО РостГМУ Минздрава России) | Method of treating patients suffering pulmonary tuberculosis |
| RU2676761C1 (en) * | 2017-10-09 | 2019-01-11 | Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" | Polyionic infusion solution |
| RU2678313C1 (en) * | 2018-02-27 | 2019-01-25 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Амурская государственная медицинская академия" Министерства здравоохранения Российской Федерации | Method for reducing toxic damage of rats' liver by a carbon tetrachlorated |
-
1998
- 1998-12-02 EA EA199801066A patent/EA000879B1/en not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2677856C2 (en) * | 2014-04-29 | 2019-01-22 | Гуменюк Мыкола Ивановыч | Pharmaceutical composition for treatment of chronic obstructive lung diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| EA000879B1 (en) | 2000-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC4A | Registration of transfer of a eurasian patent by assignment | ||
| QB4A | Registration of a licence in a contracting state | ||
| PC4A | Registration of transfer of a eurasian patent by assignment | ||
| QB4A | Registration of a licence in a contracting state | ||
| QZ4A | Registered corrections and amendments in a licence | ||
| QB4A | Registration of a licence in a contracting state | ||
| QB4A | Registration of a licence in a contracting state | ||
| QB4A | Registration of a licence in a contracting state | ||
| QB4A | Registration of a licence in a contracting state | ||
| TK4A | Corrections in published eurasian patents | ||
| MK4A | Patent expired |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |
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| QC4A | Termination of a registered licence in a contracting state |