RU2001111373A - COMPOSITION OF PERFLUOROUS CARBIDE SUBSTITUTE BASED ON PERFUORORGANIC COMPOUNDS EMULSION FOR MEDICAL AND BIOLOGICAL PURPOSES - Google Patents

COMPOSITION OF PERFLUOROUS CARBIDE SUBSTITUTE BASED ON PERFUORORGANIC COMPOUNDS EMULSION FOR MEDICAL AND BIOLOGICAL PURPOSES

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Publication number
RU2001111373A
RU2001111373A RU2001111373/14A RU2001111373A RU2001111373A RU 2001111373 A RU2001111373 A RU 2001111373A RU 2001111373/14 A RU2001111373/14 A RU 2001111373/14A RU 2001111373 A RU2001111373 A RU 2001111373A RU 2001111373 A RU2001111373 A RU 2001111373A
Authority
RU
Russia
Prior art keywords
composition
blood substitute
perfluorocarbon
perfuororganic
perfluorous
Prior art date
Application number
RU2001111373/14A
Other languages
Russian (ru)
Other versions
RU2199311C2 (en
Original Assignee
Воробьев Сергей Иванович
Filing date
Publication date
Application filed by Воробьев Сергей Иванович filed Critical Воробьев Сергей Иванович
Priority to RU2001111373A priority Critical patent/RU2199311C2/en
Priority claimed from RU2001111373A external-priority patent/RU2199311C2/en
Publication of RU2001111373A publication Critical patent/RU2001111373A/en
Application granted granted Critical
Publication of RU2199311C2 publication Critical patent/RU2199311C2/en

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Claims (3)

1. Состав перфторуглеродного кровезаменителя на основе эмульсий перфторорганических соединений (ПФОС) для медико-биологичнских целей, включающий перфторорганические соединения и проксанол, отличающийся тем, что перфторуглеродный кровезаменитель, состоящий из смеси двух ПФОС: перфтордекалина (ПФД)/перфторметилциклогексилпиперидина (ПФМЦП), в соотношении 2/1 соответственно, концентрацией 1 - 30%, эмульгированных проксанолом 268, концентрацией 0,2 - 6%, не содержит крупнодисперсных частиц перфторуглеродной эмульсии, превышающих диаметр 0,2 мкм, способен стерилизоваться методом стерилизационной фильтрации, дополнительно имеет физиологически приемлемый электролитный раствор при следующих концентрациях ингредиентов в составе: натрия хлорида - 6,0 г/л; калия хлорида - 0,39 г/л; магния хлорида (в пересчете на сухое вещество) - 0,19 г/л; натрия гидрокарбоната - 0,65 г/л; натрия фосфата однозамещенного (в пересчете на сухое вещество) - 0,2 г/л; глюкозы - 2,0 г/л, растворенных в инъекционной воде.1. The composition of perfluorocarbon blood substitute on the basis of emulsions of perfluororganic compounds (PFOS) for biomedical purposes, including perfluororganic compounds and proxanol, characterized in that the perfluorocarbon blood substitute, consisting of a mixture of two PFOS: perfluorodecalin (PFD) / perfluoromethylphenylphenylphenylphenylphenylphenylphenylphenylphenylphenylphenylphenylphenylphenylphenylphenylphenylphenylphenylphenylphenylphenylphenylphenylphenoxymethyl and benzofluorodiphenylphenylphenoxyphenylphenylphenylphenylphenylphenylphenoxymethylphenoxymethylphenylmethylphenylphenylphenoxymethyl (chlorofluoromethyl) 2/1, respectively, with a concentration of 1 - 30% emulsified with proxanol 268, a concentration of 0.2 - 6%, does not contain coarse particles of perfluorocarbon emulsion exceeding a diameter of 0.2 μm, s Able to sterilize by sterilization filtration, additionally has a physiologically acceptable electrolyte solution at the following concentrations of ingredients in the composition: sodium chloride - 6.0 g / l; potassium chloride - 0.39 g / l; magnesium chloride (in terms of dry matter) - 0.19 g / l; sodium bicarbonate - 0.65 g / l; monosubstituted sodium phosphate (in terms of dry matter) - 0.2 g / l; glucose - 2.0 g / l dissolved in injection water. 2. Состав перфторуглеродного кровезаменителя по п. 1, отличающийся тем, что кровезаменитель предназначен для внутривенного, внутриартериального, перорального и внутриполостного применения и перед употреблением разводится от 1,2 до 12 раз любым совместимым с кровезаменителем раствором или составом. 2. The composition of the perfluorocarbon blood substitute according to claim 1, characterized in that the blood substitute is intended for intravenous, intraarterial, oral and intracavitary use and is diluted from 1.2 to 12 times with any solution or composition compatible with the blood substitute. 3. Состав перфторуглеродного кровезаменителя по пп. 1 и 2, отличающийся тем, что кровезаменитель предназначен для наружного использования в качестве среды для орошения или смачивания долго не заживляющих ран, язв и других заболеваний. 3. The composition of perfluorocarbon blood substitute according to paragraphs. 1 and 2, characterized in that the blood substitute is intended for external use as a medium for irrigation or soaking of non-healing wounds, ulcers and other diseases.
RU2001111373A 2001-04-26 2001-04-26 Composition of perfluorocarbon blood substitute based on emulsion of perfluoroorganic compounds for medical-biological aims RU2199311C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2001111373A RU2199311C2 (en) 2001-04-26 2001-04-26 Composition of perfluorocarbon blood substitute based on emulsion of perfluoroorganic compounds for medical-biological aims

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2001111373A RU2199311C2 (en) 2001-04-26 2001-04-26 Composition of perfluorocarbon blood substitute based on emulsion of perfluoroorganic compounds for medical-biological aims

Publications (2)

Publication Number Publication Date
RU2001111373A true RU2001111373A (en) 2003-02-20
RU2199311C2 RU2199311C2 (en) 2003-02-27

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Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2259819C1 (en) 2004-03-01 2005-09-10 Кузнецова Ирина Николаевна Emulsion of perfluoroorganic compounds of medicinal indication and method for its obtaining
CN101437502A (en) 2006-03-14 2009-05-20 谢尔盖·伊万诺维奇·沃罗比耶夫 Perfluocarbon gaseous transfer emulsion composition for medicament and biology, and obtaining method thereof and medicament
WO2008082321A1 (en) * 2006-12-28 2008-07-10 Germanov, Evgeny Pavlovich Emulsion of perfluoroorganic compounds for medical use and a methods for the preparation and the use thereof
RU2469714C1 (en) * 2011-07-15 2012-12-20 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") Emulsion of perfluoroorganic compounds with gas transport properties
RU2518313C2 (en) * 2012-05-17 2014-06-10 Сергей Иванович Воробьев Perfluorinated blood substitute - gas transport donor blood substitute: formulation and treatment
RU2745290C2 (en) * 2019-04-12 2021-03-23 Ирина Николаевна Кузнецова Emulsion of perfluorocarbon compounds for biomedical purposes and a method for its production

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