EA199801015A1 - DERIVATIVES OF PIPERIDINOXIC ACID AND THEIR APPLICATION IN THE TREATMENT OF THROMBOTIC DISORDERS - Google Patents

DERIVATIVES OF PIPERIDINOXIC ACID AND THEIR APPLICATION IN THE TREATMENT OF THROMBOTIC DISORDERS

Info

Publication number
EA199801015A1
EA199801015A1 EA199801015A EA199801015A EA199801015A1 EA 199801015 A1 EA199801015 A1 EA 199801015A1 EA 199801015 A EA199801015 A EA 199801015A EA 199801015 A EA199801015 A EA 199801015A EA 199801015 A1 EA199801015 A1 EA 199801015A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
application
piperidinoxic
derivatives
acid
Prior art date
Application number
EA199801015A
Other languages
Russian (ru)
Inventor
Дейвид Джордж Аллен
Колин Дейвид Элдред
Брайан Дейвид Джадкинс
Уильям Леонард Митчелл
Original Assignee
Глаксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9613017.4A external-priority patent/GB9613017D0/en
Priority claimed from GBGB9613095.0A external-priority patent/GB9613095D0/en
Priority claimed from GBGB9613018.2A external-priority patent/GB9613018D0/en
Application filed by Глаксо Груп Лимитед filed Critical Глаксо Груп Лимитед
Publication of EA199801015A1 publication Critical patent/EA199801015A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к соединениям формулы (I) или их соли, сольвату или физиологически функциональному производному, в которых Х представляет собой либо СН-СНлибо СН=СН; Y представляет собой группу (а) или (б); Rпредставляет собой SOMe или CONHи Rпредставляет собой SOMe, к способам их получения, к фармацевтическим композициям, содержащим такие соединения, и к их применению в медицине, в частности при лечении тромботических нарушений.Международная заявка была опубликована вместе с отчетом о международном поиске.The invention relates to compounds of formula (I) or their salts, solvate or physiologically functional derivative, in which X is either CH-CH or CH = CH; Y is a group of (a) or (b); R represents SOMe or CONH and R represents SOMe, to methods for their preparation, to pharmaceutical compositions containing such compounds, and to their use in medicine, in particular in the treatment of thrombotic disorders. The international application was published together with an international search report.

EA199801015A 1996-06-21 1997-06-19 DERIVATIVES OF PIPERIDINOXIC ACID AND THEIR APPLICATION IN THE TREATMENT OF THROMBOTIC DISORDERS EA199801015A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9613017.4A GB9613017D0 (en) 1996-06-21 1996-06-21 Therapeutic compounds
GBGB9613095.0A GB9613095D0 (en) 1996-06-21 1996-06-21 Therapeutic piperidines
GBGB9613018.2A GB9613018D0 (en) 1996-06-21 1996-06-21 Therapeutic indazoles
PCT/EP1997/003196 WO1997049699A1 (en) 1996-06-21 1997-06-19 Piperidine acetic acid derivatives and their use in the treatment of thrombotic disorders

Publications (1)

Publication Number Publication Date
EA199801015A1 true EA199801015A1 (en) 1999-08-26

Family

ID=27268341

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199801015A EA199801015A1 (en) 1996-06-21 1997-06-19 DERIVATIVES OF PIPERIDINOXIC ACID AND THEIR APPLICATION IN THE TREATMENT OF THROMBOTIC DISORDERS

Country Status (17)

Country Link
EP (1) EP0912555A1 (en)
JP (1) JP2000512648A (en)
KR (1) KR20000022041A (en)
AP (1) AP9801417A0 (en)
AR (1) AR008245A1 (en)
AU (1) AU3261197A (en)
BR (1) BR9709930A (en)
CA (1) CA2258753A1 (en)
CZ (1) CZ424698A3 (en)
EA (1) EA199801015A1 (en)
ID (1) ID17052A (en)
IL (1) IL127464A0 (en)
IS (1) IS4924A (en)
NO (1) NO985974L (en)
PL (1) PL330797A1 (en)
TR (1) TR199802665T2 (en)
WO (1) WO1997049699A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7642278B2 (en) 2001-07-03 2010-01-05 Novartis Vaccines And Diagnostics, Inc. Indazole benzimidazole compounds
US7064215B2 (en) 2001-07-03 2006-06-20 Chiron Corporation Indazole benzimidazole compounds
TW200401641A (en) 2002-07-18 2004-02-01 Wyeth Corp 1-Heterocyclylalkyl-3-sulfonylindole or-indazole derivatives as 5-hydroxytryptamine-6 ligands
MXPA05008438A (en) * 2003-02-14 2005-10-19 Wyeth Corp Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands.
WO2007117413A1 (en) 2006-04-05 2007-10-18 Wyeth Sulfonyl-3-heterocyclylindazole derivatives as 5-hydroxytryptamine-6 ligands
MX2009007416A (en) 2007-01-10 2009-07-17 Hoffmann La Roche Sulfonamide derivatives as chymase inhibitors.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4124942A1 (en) * 1991-07-27 1993-01-28 Thomae Gmbh Dr K 5-LOW HETEROCYCLES, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENTS CONTAINING SUCH COMPOUNDS
JPH07501063A (en) * 1991-11-14 1995-02-02 グラクソ、グループ、リミテッド Piperidine acetic acid derivatives as fibrinogen-dependent platelet aggregation inhibitors
GB9208740D0 (en) * 1992-04-23 1992-06-10 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
CA2258753A1 (en) 1997-12-31
WO1997049699A1 (en) 1997-12-31
IS4924A (en) 1998-12-15
JP2000512648A (en) 2000-09-26
NO985974D0 (en) 1998-12-18
AR008245A1 (en) 1999-12-29
ID17052A (en) 1997-12-04
KR20000022041A (en) 2000-04-25
CZ424698A3 (en) 1999-05-12
AU3261197A (en) 1998-01-14
EP0912555A1 (en) 1999-05-06
TR199802665T2 (en) 1999-03-22
AP9801417A0 (en) 1998-12-31
IL127464A0 (en) 1999-10-28
BR9709930A (en) 1999-08-10
NO985974L (en) 1999-02-17
PL330797A1 (en) 1999-06-07

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