EA199800057A1 - Применение производных пиррола, производные пиррола, способ их получения, фармацевтическая композиция на их основе и ассоциация производных пиррола с антиретровирусным агентом - Google Patents
Применение производных пиррола, производные пиррола, способ их получения, фармацевтическая композиция на их основе и ассоциация производных пиррола с антиретровирусным агентомInfo
- Publication number
- EA199800057A1 EA199800057A1 EA199800057A EA199800057A EA199800057A1 EA 199800057 A1 EA199800057 A1 EA 199800057A1 EA 199800057 A EA199800057 A EA 199800057A EA 199800057 A EA199800057 A EA 199800057A EA 199800057 A1 EA199800057 A1 EA 199800057A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pyrrol derivatives
- derivatives
- pyrrol
- alkyl
- association
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Новое терапевтическое применение производных пиррола общей формулы (I)в которой Het означает конденсированный с пирролом цикл, такой, что он образует пирролотиазольный, 5,6,7,8-тетрагидроиндолизиновый, дигидропирролотиазиновый или дигидропирролизиновый цикл; Rозначает карбоксамидогруппу, цианогруппу, карбоксил, алкоксикарбонил, ацил или имидазолилкарбонил; Rозначает атом водорода или галогена, или алкильный, алкенильный, тригалогенметильный радикал, или цианогруппу; Rозначает атом водорода или галогена, или гидроксильный, или алкильный радикал; и Het' означает пиридил, пиридил-N-оксид или тиазолил, причем алкильные или ацильные радикалы являются линейными или разветвленными (с 1-4 атомами углерода) и алкенильные радикалы являются линейными или разветвленными (с 2-4 атомами углерода), так же как их солей, когда они имеются, для получения лекарственного средства, предназначенного для лечения заболеваний, в которых принимает участие фактор некроза опухоли.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9507055A FR2735476B1 (fr) | 1995-06-14 | 1995-06-14 | Nouvelle application de derives du pyrrole |
PCT/FR1996/000887 WO1997000073A1 (fr) | 1995-06-14 | 1996-06-12 | Nouvelle application de derives du pyrrole |
Publications (1)
Publication Number | Publication Date |
---|---|
EA199800057A1 true EA199800057A1 (ru) | 1998-10-29 |
Family
ID=9479965
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199800057A EA199800057A1 (ru) | 1995-06-14 | 1996-06-12 | Применение производных пиррола, производные пиррола, способ их получения, фармацевтическая композиция на их основе и ассоциация производных пиррола с антиретровирусным агентом |
Country Status (19)
Country | Link |
---|---|
US (1) | US6194426B1 (ru) |
EP (1) | EP0833635A1 (ru) |
JP (1) | JP2001510437A (ru) |
KR (1) | KR19990022908A (ru) |
AU (1) | AU6309396A (ru) |
BR (1) | BR9609000A (ru) |
CA (1) | CA2221027A1 (ru) |
CZ (1) | CZ400697A3 (ru) |
EA (1) | EA199800057A1 (ru) |
FR (1) | FR2735476B1 (ru) |
HU (1) | HUP9901625A2 (ru) |
IL (1) | IL122560A0 (ru) |
NO (1) | NO975811D0 (ru) |
PL (1) | PL328669A1 (ru) |
SK (1) | SK171697A3 (ru) |
TR (1) | TR199701604T2 (ru) |
TW (1) | TW336935B (ru) |
WO (1) | WO1997000073A1 (ru) |
ZA (1) | ZA964932B (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5871537A (en) | 1996-02-13 | 1999-02-16 | Scimed Life Systems, Inc. | Endovascular apparatus |
FR2757166B1 (fr) * | 1996-12-12 | 1999-01-29 | Rhone Poulenc Rorer Sa | Derives du pyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2779724B1 (fr) * | 1998-06-10 | 2001-04-20 | Rhone Poulenc Rorer Sa | Derives du pyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent |
US20040014744A1 (en) * | 2002-04-05 | 2004-01-22 | Fortuna Haviv | Substituted pyridines having antiangiogenic activity |
GB0816759D0 (en) * | 2008-09-12 | 2008-10-22 | Selcia Ltd | Compounds |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3931201A (en) * | 1974-01-22 | 1976-01-06 | The Dow Chemical Company | Substituted pyridinyloxy(thio)phenyl -acetamides, -ureas and urea derivatives |
FR2539417A1 (fr) * | 1983-01-13 | 1984-07-20 | Rhone Poulenc Sante | Nouveaux pyrrolo-1, 2 heterocycles, leur preparation et les medicaments qui les contiennent |
FR2557111B1 (fr) | 1983-12-21 | 1986-04-11 | Rhone Poulenc Sante | Nouveaux derives ortho-condenses du pyrrole, leur preparation et les medicaments qui les contiennent |
DK704488D0 (da) * | 1988-12-19 | 1988-12-19 | Novo Industri As | Nye n-substituerede azaheterocykliske carboxylsyrer |
FR2678834A1 (fr) * | 1991-07-09 | 1993-01-15 | Rhone Poulenc Rorer Sa | Nouvelle application therapeutique du pyridylpyrrolothiazole carboxamide. |
-
1995
- 1995-06-14 FR FR9507055A patent/FR2735476B1/fr not_active Expired - Fee Related
-
1996
- 1996-06-10 TW TW085106956A patent/TW336935B/zh active
- 1996-06-10 ZA ZA964932A patent/ZA964932B/xx unknown
- 1996-06-12 BR BR9609000A patent/BR9609000A/pt not_active Application Discontinuation
- 1996-06-12 PL PL96328669A patent/PL328669A1/xx unknown
- 1996-06-12 WO PCT/FR1996/000887 patent/WO1997000073A1/fr not_active Application Discontinuation
- 1996-06-12 AU AU63093/96A patent/AU6309396A/en not_active Abandoned
- 1996-06-12 CA CA002221027A patent/CA2221027A1/fr not_active Abandoned
- 1996-06-12 SK SK1716-97A patent/SK171697A3/sk unknown
- 1996-06-12 JP JP50270597A patent/JP2001510437A/ja active Pending
- 1996-06-12 EP EP96922100A patent/EP0833635A1/fr not_active Withdrawn
- 1996-06-12 US US08/981,095 patent/US6194426B1/en not_active Expired - Fee Related
- 1996-06-12 HU HU9901625A patent/HUP9901625A2/hu unknown
- 1996-06-12 KR KR1019970709377A patent/KR19990022908A/ko not_active Application Discontinuation
- 1996-06-12 CZ CZ974006A patent/CZ400697A3/cs unknown
- 1996-06-12 TR TR97/01604T patent/TR199701604T2/xx unknown
- 1996-06-12 EA EA199800057A patent/EA199800057A1/ru unknown
-
1997
- 1997-12-10 NO NO975811A patent/NO975811D0/no not_active Application Discontinuation
- 1997-12-11 IL IL12256097A patent/IL122560A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
NO975811L (no) | 1997-12-10 |
CA2221027A1 (fr) | 1997-01-03 |
PL328669A1 (en) | 1999-02-15 |
WO1997000073A1 (fr) | 1997-01-03 |
SK171697A3 (en) | 1998-07-08 |
US6194426B1 (en) | 2001-02-27 |
ZA964932B (en) | 1997-01-06 |
JP2001510437A (ja) | 2001-07-31 |
MX9709150A (es) | 1998-03-31 |
FR2735476A1 (fr) | 1996-12-20 |
AU6309396A (en) | 1997-01-15 |
TW336935B (en) | 1998-07-21 |
EP0833635A1 (fr) | 1998-04-08 |
HUP9901625A2 (hu) | 1999-09-28 |
TR199701604T2 (xx) | 2000-10-23 |
NO975811D0 (no) | 1997-12-10 |
FR2735476B1 (fr) | 1997-07-18 |
IL122560A0 (en) | 1998-06-15 |
CZ400697A3 (cs) | 1998-03-18 |
KR19990022908A (ko) | 1999-03-25 |
BR9609000A (pt) | 1999-06-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE178044T1 (de) | Inhibitoren des arginin-ketoamid-enzyms | |
ES2080900T3 (es) | Derivados piranicos utiles como inhibidores de 5-lipoxigenasa. | |
GEP20033053B (en) | Substituted Pyrazoles as P38 Kinase Inhibitors, Methods for their Production, Pharmaceutical Compositions Containing Them and Methods for Treatment | |
PL306590A1 (en) | Substituted heterocyclic carboxylamides, method obtaining them and their application as therapeutic agents | |
DE60316779D1 (de) | Thiadiazolylpiperazinderivate geeignet für die behandlung bzw. prävention von schmerzen | |
HUP0105414A2 (hu) | Pirrolo-izokinolin-, azepino- és diazepino-indol-származékok, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények | |
NO981911L (no) | Anvendelse av rhodaninderivater for fremstilling av et medikament for behandling av Alzheimer's sykdom | |
ATE273279T1 (de) | 2,3,5-trisubstituierte pyridine als inhibitoren von cyclooxygenase-2 | |
AU2002314914A1 (en) | Hydroxy alkyl amine derivatives as beta-secretase inhibitors and their use for the treatment of alzheimer's disease and similar diseases | |
ATE226574T1 (de) | 4,6-diarylpyrimidin-derivate und deren salze | |
DE69825154D1 (de) | Pyridazinone als inhibitoren von cyclooxygenase-2 | |
NO931317L (no) | Et terapeutisk middel for parkinson's sykdom | |
FR2705343B1 (fr) | Dérivés de beta,beta-diméthyl-4-pipéridineéthanamine, leur procédé de préparation et leur utilisation en thérapeutique. | |
KR950014067A (ko) | 아릴아미드유도체 | |
DE69131359D1 (de) | Kondensierte Thiazolverbindungen, ihre Darstellung und ihre Anwendung | |
DE69413118D1 (de) | Benzolsulfonamid-Derivate zur Behandlung der Blaseninstabilität | |
EA199800057A1 (ru) | Применение производных пиррола, производные пиррола, способ их получения, фармацевтическая композиция на их основе и ассоциация производных пиррола с антиретровирусным агентом | |
RU94045271A (ru) | Применение 2-фенил-3-ароилбензотиофенов для ингибирования синдрома тернера | |
ATE284684T1 (de) | Amidderivate zur behandlung neurodegenerativer erkrankungen der netzhaut | |
KR920019785A (ko) | 벤조티아졸 유도체 | |
ATE293602T1 (de) | 2-aminopyridine als inhibitoren von cyclooxygenase-2 | |
DE69119642T2 (de) | Verwendung von Pyrido-Indol-Derivaten bei der Behandlung ischämischer Störungen | |
DE69619088T2 (de) | Quinoxalin-Derivate zur Behandlung von Tinnitus | |
FR2663026B1 (fr) | Derives de [(1-arylpyrrolidin-2-yl) methyl] piperazine, leur preparation et leur application en therapeutique. | |
ITMI920082A1 (it) | Derivati solforati di acidi biliari |