EA199800046A1 - POLYPEPTIDE, DNA SEQUENCE, VACCINE COMPOSITION (OPTIONS), ANTIBODY OR ITS FRAGMENT, VACCINE, APPLICATIONS OF POLYPEPTIDE-INDICATED, DNA SEQUENCE AND ANTIBODY OR ITS FRAGMENT - Google Patents

POLYPEPTIDE, DNA SEQUENCE, VACCINE COMPOSITION (OPTIONS), ANTIBODY OR ITS FRAGMENT, VACCINE, APPLICATIONS OF POLYPEPTIDE-INDICATED, DNA SEQUENCE AND ANTIBODY OR ITS FRAGMENT

Info

Publication number
EA199800046A1
EA199800046A1 EA199800046A EA199800046A EA199800046A1 EA 199800046 A1 EA199800046 A1 EA 199800046A1 EA 199800046 A EA199800046 A EA 199800046A EA 199800046 A EA199800046 A EA 199800046A EA 199800046 A1 EA199800046 A1 EA 199800046A1
Authority
EA
Eurasian Patent Office
Prior art keywords
seq
polypeptide
antibody
fragment
dna sequence
Prior art date
Application number
EA199800046A
Other languages
Russian (ru)
Inventor
Бернар Р. Бродор
Денис Мартэн
Клеман Риу
Хосе Хамел
Original Assignee
Байокем Вэксинс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/472,534 external-priority patent/US5919620A/en
Application filed by Байокем Вэксинс Инк. filed Critical Байокем Вэксинс Инк.
Publication of EA199800046A1 publication Critical patent/EA199800046A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Описаны новые белки теплового шока (HSP) Streptococcus pneumoniae, Streptococcus pyogenes и Streptococcus agalactiae, имеющие приблизительную молекулярную массу 70-72 кДа, иммунологически родственные полипептиды, нуклеотидные и соответствующие аминокислотные последовательности HSP72 S.pneumoniae (SEQ ID NO: 4, SEQ ID NO: 5), нуклеотидные и соответствующие аминокислотные последовательности HSP70 S.pyogenes (SEQ ID NO: 19, SEQ ID NO: 20), нуклеотидные и соответствующие аминокислотные последовательности HSP70 S.agalactiae (SEQ ID NO: 21, SEQ ID NO: 22); антитела, связывающие HSP, способы с использованием рекомбинантных ДНК для получения HSP и иммунологически родственных полипептидов. Полипептиды, последовательности ДНК и антитела, полученные согласно данному изобретению, могут быть использованы для получения новых средств диагностики, профилактики и/или лечения заболеваний, вызванных стрептококками.Международная заявка была опубликована вместе с отчетом о международном поиске.New heat shock proteins (HSP) of Streptococcus pneumoniae, Streptococcus pyogenes and Streptococcus agalactiae, with an approximate molecular weight of 70-72 kDa, immunologically related polypeptides, nucleotide and corresponding amino acid sequences of HSP72 S.pneumoniae (SEQ ID NO: 4, SE, ID, SEQ ID NO: 4, SEQ ID NO: 4, SEQ ID NO: 4, SE, ID, SE, ID, 4, SEP, NO, 4, SEP, NO. 5) the nucleotide and corresponding amino acid sequences of S. pyogenes HSP70 (SEQ ID NO: 19, SEQ ID NO: 20), the nucleotide and corresponding amino acid sequences of S. agalactiae HSP70 (SEQ ID NO: 21, SEQ ID NO: 22); antibodies that bind HSP, methods using recombinant DNA to produce HSP and immunologically related polypeptides. The polypeptides, DNA sequences and antibodies obtained according to this invention can be used to obtain new diagnostic tools, prevention and / or treatment of diseases caused by streptococci. The international application was published along with an international search report.

EA199800046A 1995-06-07 1996-05-17 POLYPEPTIDE, DNA SEQUENCE, VACCINE COMPOSITION (OPTIONS), ANTIBODY OR ITS FRAGMENT, VACCINE, APPLICATIONS OF POLYPEPTIDE-INDICATED, DNA SEQUENCE AND ANTIBODY OR ITS FRAGMENT EA199800046A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/472,534 US5919620A (en) 1995-06-07 1995-06-07 Heat shock protein HSP72 of Streptococcus pneumoniae
US180595P 1995-08-04 1995-08-04
PCT/CA1996/000322 WO1996040928A1 (en) 1995-06-07 1996-05-17 Streptococcal heat shock proteins members of the hsp70 family

Publications (1)

Publication Number Publication Date
EA199800046A1 true EA199800046A1 (en) 1998-06-25

Family

ID=26669494

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800046A EA199800046A1 (en) 1995-06-07 1996-05-17 POLYPEPTIDE, DNA SEQUENCE, VACCINE COMPOSITION (OPTIONS), ANTIBODY OR ITS FRAGMENT, VACCINE, APPLICATIONS OF POLYPEPTIDE-INDICATED, DNA SEQUENCE AND ANTIBODY OR ITS FRAGMENT

Country Status (18)

Country Link
EP (1) EP0832238A1 (en)
JP (1) JPH11507214A (en)
KR (1) KR19990022742A (en)
CN (1) CN1192241A (en)
AP (1) AP9701163A0 (en)
AR (1) AR003124A1 (en)
AU (1) AU700080B2 (en)
BR (1) BR9609399A (en)
CA (1) CA2224015A1 (en)
CZ (1) CZ394297A3 (en)
EA (1) EA199800046A1 (en)
HU (1) HUP0600442A3 (en)
IL (1) IL118329A0 (en)
NO (1) NO975752L (en)
PL (1) PL323781A1 (en)
SK (1) SK168497A3 (en)
TR (1) TR199701537T1 (en)
WO (1) WO1996040928A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245335B1 (en) 1996-05-01 2001-06-12 The Rockefeller University Choline binding proteins for anti-pneumococcal vaccines
EP0912608B1 (en) * 1996-05-01 2006-04-19 The Rockefeller University Choline binding proteins for anti-pneumococcal vaccines
AU1866099A (en) * 1997-12-31 1999-07-26 Stressgen Biotechnologies Corporation Streptococcal heat shock proteins of the hsp60 family
US6497880B1 (en) 1998-12-08 2002-12-24 Stressgen Biotechnologies Corporation Heat shock genes and proteins from Neisseria meningitidis, Candida glabrata and Aspergillus fumigatus
US7128918B1 (en) 1998-12-23 2006-10-31 Id Biomedical Corporation Streptococcus antigens
CZ303675B6 (en) * 1998-12-23 2013-02-27 Id Biomedical Corporation Of Quebec Isolated polynucleotide, vector, host cell, production process, isolated polypeptide, chimeric polypeptide, vaccine composition and use
AR022963A1 (en) 1999-03-19 2002-09-04 Smithkline Beecham Biolog VACCINE
US7015309B1 (en) 1999-06-23 2006-03-21 The Wistar Institute Of Anatomy And Biology Pyrrhocoricin-derived peptides, and methods of use thereof
GB9918319D0 (en) 1999-08-03 1999-10-06 Smithkline Beecham Biolog Vaccine composition
GB9919734D0 (en) * 1999-08-19 1999-10-20 Colaco Camilo Vaccines from infectious agents
AU2005204321B2 (en) * 1999-08-19 2008-07-10 Immunobiology Limited Vaccines from Infectious Agents
EP1252517A4 (en) * 2000-01-21 2004-10-20 Wistar Inst Biocidal molecules, macromolecular targets and methods of production and use
US6833134B2 (en) 2000-06-12 2004-12-21 University Of Saskacthewan Immunization of dairy cattle with GapC protein against Streptococcus infection
US6866855B2 (en) 2000-06-12 2005-03-15 University Of Saskatchewan Immunization of dairy cattle with GapC protein against Streptococcus infection
EP1294771B1 (en) 2000-06-12 2008-10-29 University Of Saskatchewan Chimeric GapC protein from Streptococcus and its use in vaccination and diagnosis
GB0021757D0 (en) * 2000-09-04 2000-10-18 Colaco Camilo Vaccine against microbial pathogens
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
US20060034854A1 (en) 2002-08-02 2006-02-16 Berthet Francois-Xavier J Vaccine composition comprising transferrin binding protein and hsf from gram negative bacteria
EP1556477B1 (en) 2002-11-01 2017-08-09 GlaxoSmithKline Biologicals s.a. Drying process
EP2287313A1 (en) * 2003-03-04 2011-02-23 Intercell AG Streptococcus pyogenes antigens
AU2004230244B2 (en) * 2003-04-15 2011-09-22 Intercell Ag S. pneumoniae antigens
US8574596B2 (en) 2003-10-02 2013-11-05 Glaxosmithkline Biologicals, S.A. Pertussis antigens and use thereof in vaccination
GB0505996D0 (en) 2005-03-23 2005-04-27 Glaxosmithkline Biolog Sa Fermentation process
TWI457133B (en) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa Novel composition
ZA200805602B (en) 2006-01-17 2009-12-30 Arne Forsgren A novel surface exposed haemophilus influenzae protein (protein E; pE)
JP2013521770A (en) 2010-03-10 2013-06-13 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Vaccine composition
GB201015132D0 (en) 2010-09-10 2010-10-27 Univ Bristol Vaccine composition
CN103146734B (en) * 2013-03-12 2014-10-01 中国人民解放军军事医学科学院军事兽医研究所 Anti-burn and scald infection multiple organ failure Pseudomonas aeruginosa toxin vaccine
CN104001164A (en) * 2014-04-23 2014-08-27 杭州师范大学 Aeromonas hydrophila heat shock protein subunit vaccine and preparation method thereof
CN114805567B (en) * 2022-06-27 2022-09-16 和元生物技术（上海）股份有限公司 Monoclonal antibody, method and application of marker protein HSPA1A for recognizing exosomes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA921025B (en) * 1991-02-15 1992-11-25 Uab Research Foundation Structural gene of pneumococcal protein
IT1262896B (en) * 1992-03-06 1996-07-22 CONJUGATE COMPOUNDS FORMED FROM HEAT SHOCK PROTEIN (HSP) AND OLIGO-POLY-SACCHARIDES, THEIR USE FOR THE PRODUCTION OF VACCINES.

Also Published As

Publication number Publication date
NO975752L (en) 1998-02-06
CZ394297A3 (en) 1998-04-15
NO975752D0 (en) 1997-12-05
HUP0600442A2 (en) 2006-08-28
CA2224015A1 (en) 1996-12-19
IL118329A0 (en) 1996-09-12
AR003124A1 (en) 1998-07-08
AU700080B2 (en) 1998-12-17
PL323781A1 (en) 1998-04-27
TR199701537T1 (en) 1998-03-21
EP0832238A1 (en) 1998-04-01
JPH11507214A (en) 1999-06-29
BR9609399A (en) 2001-08-28
SK168497A3 (en) 1998-07-08
AP9701163A0 (en) 1998-01-31
HUP0600442A3 (en) 2007-03-28
CN1192241A (en) 1998-09-02
AU5682896A (en) 1996-12-30
WO1996040928A1 (en) 1996-12-19
KR19990022742A (en) 1999-03-25

Similar Documents

Publication Publication Date Title
EA199800046A1 (en) POLYPEPTIDE, DNA SEQUENCE, VACCINE COMPOSITION (OPTIONS), ANTIBODY OR ITS FRAGMENT, VACCINE, APPLICATIONS OF POLYPEPTIDE-INDICATED, DNA SEQUENCE AND ANTIBODY OR ITS FRAGMENT
Porter Chemical structure of γ-globulin and antibodies
NL930013I1 (en) Recombinant DNA, host proteins transformed therewith by hosts produced polypeptides; methods of preparation thereof, detection methods using the polypeptides; compositions and agents containing the polypeptides; DNA sequences
EA199700248A1 (en) ESSENTIALLY DETERMINED PURIFIED SURFACE ANTIGEN OF PROTEIN NATURE NEISSERIA AND FRAGMENT OF THIS ANTIGEN
KR950032279A (en) Peptides Related to Programmed Cell Death in the Human Body and DNA Encoding them
Gallizia et al. Production of a Soluble and Functional Recombinant Streptavidin inEscherichia coli
CA2289912A1 (en) Human receptor proteins; related reagents and methods
ATE365744T1 (en) NUCLEIC ACID MOLECULES, PROTEINS AND PEPTIDES ASSOCIATED WITH COLON CELLS AND COLON CANCER CELLS
NO995689D0 (en) Compounds for immunotherapy and diagnosis of tuberculosis and methods for their use
ATE301716T1 (en) VMP-LIKE SEQUENCES OF PATHOGENIC BORRELIA
ATE135403T1 (en) PREPARATION AND PURIFICATION OF A PROTEIN FUSIONED WITH A BINDING PROTEIN
Sjöbring et al. Isolation and characterization of a 14-kDa albumin-binding fragment of streptococcal protein G.
TR27970A (en) New signal sequences that are used to target the plant.
RU98112759A (en) HUMAN SEMAPHORIN L (H-SEMA-L) AND RELATED SEMAPHORINS IN OTHER SPECIES
KR880003006A (en) Polypeptide of rhinovirus strain HRV 89 and DNA molecule encoding the same
WO1995008628A3 (en) Nucleic acids encoding merosin, merosin fragments and uses thereof
MX9709557A (en) Streptococcal heat shock proteins members of the hsp70 family.
Gorman et al. Characterisation of the third component of canine and feline complement
CA2642146A1 (en) Xrec2 dnas and polypeptides
AU2014274586B2 (en) Nucleic acids and proteins from streptococcus groups A & B
KR930023459A (en) Nucleic acid molecules encoding the genetic powder precursor mutant protein, vectors and cells comprising the same, methods for detecting the presence of recombinant polypeptides and polypeptides produced thereby
WO2001046412A3 (en) Interaction proteins for the stat transcription factor
HUP0002541A2 (en) Mammalian cytokine-like factor 7