EA043462B1 - REJUVENATING SERUM BASED ON HYALURONIC ACID AND COLLAGEN (2 OPTIONS) - Google Patents

Description

The invention relates to the field of medicine and cosmetology, in particular to liquid consistency products for additional care of the skin of the face, neck and décolleté.

The well-known moisturizing facial serum Regenerin (RU patent No. 2469704, published 12/20/2012). Serum for external use with an anti-inflammatory and regenerating effect, containing biologically active substances: a suspension of niosomes up to 100 Nm in size with included pig placenta extract, hyaluronic acid, propylene glycol extract of Callisia fragrans and calendula (Calendula officinalis) in a ratio of 1: 1, and the base contains Cyclomethicone DC 345, Kathon CG preservative and purified water.

A known composition for oxidative photoactivated skin rejuvenation containing hyaluronic acid, glucosamine or allantoin (EA patent No. 024725, publ. 2011.12.30). A composition for skin rejuvenation, also including at least one oxidant selected from hydrogen peroxide, carbamide peroxide and benzoyl peroxide; at least one photoactivator consisting of eosin Y or a combination of eosin Y and one or more dyes selected from pyronin Y, pyronin B, rhodamine B, rhodamine G, rhodamine WT, fluorescein, phloxin B, rose bengal, merbromine, eosin B, erythrosine, methyl violet, neutral red, parared, amaranth, carmoisine, allure red AC, tartrazine, orange G, ponceau 4R, methyl red, ammonium murexide purpurate, safranine O, alkaline fuchsine, acid fuchsine, 3,3'-dihexylcarbocyanine iodide, carmine acid, green indocyanine, crocetin, α-crocin (8,8-diapo-8,8-carotenoid acid), zeaxanthin, lycopene, α-carotene, β-carotene, bixin, fucoxanthin, red saffron powder, annatto extract and brown extract algae, in combination with a pharmaceutically acceptable carrier.

A cosmetic gel is known (patent EA No. 029943, published 2018.06.29). Cosmetic gel for accelerated granulation of skin epithelium during inflammatory processes consists of xanthan gum, hydroxyethylcellulose, glycerin, potassium sorbate, sodium benzoate, polyglyceryl-4 laurate/sebacate/polyglyceryl-6 caprylate/caprate, sodium lauryl sarcosinate, fragrance, extract from flowers, leaves and stems string of tripartite, aloe leaf extract, panthenol, dipotassium glycyrrhizinate, hyaluronic acid, citric acid and water.

A composition is known for beneficial effects on the skin using key intermediate metabolic products (Eurasian application No. 200600996, published 2007.04.27). The present invention relates to new methods and compositions comprising key metabolic components for the treatment of senile, mature, nutritionally or environmentally damaged skin. These methods and compositions provide improvements in skin appearance, physiological functions, clinical properties and biophysical properties. In specific aspects of the present invention, the at least one lipid metabolism regulator may be selected from the group consisting of sodium citrate, linoleic acid, linolenic acid, biotin, glucose, sodium acetate, mevalonic acid and serine or derivatives thereof. The at least one polysaccharide metabolism regulator may be selected from the group consisting of galactosamine, glucosamine, xylose and magnesium chloride or derivatives thereof. The at least one cellular protein metabolism regulator may be an amino acid or a derivative thereof. The amino acid may be a nonessential or essential amino acid or derivatives thereof. The nonessential amino acid may be selected from the group consisting of arginine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan and valine or derivatives thereof. Other amino acids that can be used in this invention include, for example, serine, aspartic acid, glutamic acid, asparagine, glutamine, alanine, tyrosine, cysteine, glycine and proline or derivatives thereof.

Compositions obtained from marine plants are known to provide nutrition for aging and environmentally damaged skin (PCT application No. WO 2005/0S5736, published 06.23.2005). The described compositions relate to new methods and compositions, including marine plants, for the treatment of senile, mature, nutritionally damaged or environmentally damaged skin. These methods and compositions provide improvements in the appearance, physiological functions, clinical properties and biophysical properties of the skin.

Modified derivatives of hyaluronic acid and their use are known (Eurasian application No. 201590708, published 2015.07.30). The invention relates to hyaluronic acid derivatives of formula (I), their synthesis and use as cosmetics or medicines in the body of a subject in need.

A composition in an aqueous medium is known, including at least one hyaluronic acid and at least one water-soluble salt (Eurasian application No. 201492208, publ. 2015.04.30). The invention relates to a composition comprising at least one cross-linked hyaluronic acid

- 1 043462 or a non-crosslinked structure or one of its salts and at least one water-soluble sucrose octasulfate salt, methods for producing said mixture, as well as the use of said mixture for formulating a mixture composition for viscosupplementary therapy or formulating a mixture for filling wrinkles or formulating a pharmaceutical mixture.

A known composition for oxidative photoactivated skin rejuvenation (Eurasian application No. 201170651, publ. 2011.12.30). The invention relates to a composition for skin rejuvenation comprising at least one oxidant, at least one photoactivator capable of activating the oxidant, and at least one healing factor selected from hyaluronic acid, glucosamine and allantoin, in combination with a pharmaceutically acceptable carrier.

There are a number of facial serums from the French company Novexpert (Novekspert) (https://www.relook.ru/brand/Novexpert.html), in particular the following.

Booster serum with vitamin C has a physiological pH, consisting of components of natural origin.

Active Ingredients: Vitamin C complex (Japanese stabilized vitamin C and French stabilized vitamin C combined with organic silicone), Novaxyline algae complex (NOVEXPERT patent), adenosine, fibroblast stimulating amino acid, vitamins A and E, antioxidants, hyaluronic acid, polysaccharides , 100% natural vegetable glycerin. Ingredients: Aqua (Water), Ascorbyl Methylsilanol Pectinate, Glycerin, Methylpropanediol, Propanediol, 3-O-Ethyl Ascorbic Acid, Silica, Glucosyl Hesperidin, Sodium PCA, Parfum (Fragrance), Anogeissus Lelocarpus Bark Extract, Sodium Hyaluronate, Tocopherol, Beta- Carotene, Bisabolol, Adenosine, Saccharide Isomerate, Sodium Lactate, Citric Acid, Glyceryl Caprylate, Xanthan Gum, Caprylic/Capric Triglyceride, Sclerotium Gum, CI 77891 (Titanium Dioxide), Mica, Polyglyceryl-2 Dipolyhydroxystearate, Zea Mays (Corm) Starch, Phytic Acid, Biosaccharide Gum-2, Sodium Citrate, Lauryl Glucoside, Laminaria Ochroleuca Extract.

Hyaluronic Acid serum with an instant lifting effect thanks to acacia extract, baobab pulp and hyaluronic acid.

The serum can be used both locally (lip contour, neck) and on the entire face. Consists of components of natural origin, does not contain preservatives, parabens, silicones, phenoxyethanol, mineral oils, or animal products. Active ingredients: biotechnologically obtained hyaluronic acid, plant extracts - fight against free radicals, protect against photoaging, lifting, vitamin C complex - skin radiance and antioxidant effect, polysaccharide and vegetable glycerin. Ingredients: Aqua (Water), Glycerin, Butylene Glycol, Bentonite, Acacia Senegal Gum, Caprylic/Capric Triglyceride, Xylitylglucoside, Arginine, Anhydroxylitol, Glyceryl Caprylate, Xylitol, Xanthan Gum, Rhizobian Gum, Adansonia Digitata Fruit Extract, Maltodextrin, Sodium Hyaluronate, Aloe Barbadensis Leaf Juice, Galactaric Acid, Laminaria Ochroleuca Extract, Biosaccharide Gum2, Tocopherol, Prunus Persica (Peach) Leaf Extract, Phytic Acid, Punica Granatum Seed Extract, Alcohol, Oenothera Biennis (Evening Primrose) Seed Extract, Rubus Idaeus (Raspberry) Fruit Extract, Camelia Sinensis Leaf Extract, Silybum Marianum Extract, Parfum (Fragrance), Rosmarinus Officinalis (Rosemary) Leaf Extract, Helianthus Annuus (Sunflower) Seed Oil.

There are a number of facial serums from the Russian company OOO FOLLOWING PRODUCTS, which produces Farma+Beauty cosmetics (https://www.narodkosmetika.ru/o-kompanii/, 06/06/2020), in particular the following.

Night rejuvenating serum with bio-peptide AMPOULE Peptide.

Contains a complex of chronopeptide, antioxidant and hyaluronic acid, which is aimed at long-term hydration, intensive skin smoothing and acceleration of the regeneration process; composition: Aqua (Water), Methylsilanol Hydroxyproline Aspartate, Dimethylsilanol Hyaluronate, Dercarboxy Carnosine Hcl, Glutamylamidoethyl Imidazole, Zinc Acetylmethionate, Copper Acetylmethionate, Magnesium Acetylmethionate, Manganese Acetylmethionate, Butylene Glycol, Glycerin, Propylene Gly col, Betaine, Ethylhexyl Stearate, Cyclomethicone, Xylitylglucoside, Anhydroxylitol, Xylitol, Dimethicone/Vinyl Dimethicone Crosspolymer, Dimethicone, Isohexadecane, Cetearyl Methicone, Xanthan Gum, Carbomer, Triethanolamine, Disodium EDTA, Citric Acid, Parfum, Benzyl Salicylate, Butylphenyl Methylpropional, D-Limonene, Hexyl Cinnamal, Hydroxyisohex yl 3-Cyclohexene Carboxaldehyde , Linalool, Diazolidinyl Urea, Methylparaben, Propylraben.

Serum Concentrate 3D Hyaluronic Acid & Niaciyamide.

Complex 3D Hyaluronic acid provides deep and long-lasting hydration and smoothes expression lines and age wrinkles. Niacinamide in the composition effectively regenerates the skin and prevents the accumulation of melanin in cells. This prevents the development of age spots, freckles and other imperfections. Ingredients: Aqua (Water), Sodium Hyaluronate, Glycerin, Betaine, Niacinamide, Xylitylglucoside, Anhydroxylitol, Xylitol, Polymethylsilsesquioxane, Dimethicone, Isohexadecane, Cetearyl Methicone, PEG-40 Stearate, Steareth-2, Steareth-21, Xanthan Gum, Sodium Polyacrylate, Disodium EDTA, Citric acid, Propylene Glycol, Diazolidinyl Urea, Methylparaben, Propylparaben.

Serum-activator Niacinamide 5% AMPOULE Beauty Skin.

Helps fight the first signs of aging, contains niacinamide in high concentration - 5% and a moisturizing complex. The activator serum contains up to 94.4% natural ingredients. Niacinamide (a form of vitamin B3) is an active component for cellular renewal and skin regeneration. Patented AQUAXYL™ moisturizing complex is derived from natural plant and mineral components. Ingredients: Aqua (Water), Niacinamide, Betaine, Xylitylglucoside. Anhydroxylitol, Xylitol, Glyceerin, Propylene Glycol, Aluminum Starch Octenylsuccinate, ISOPROPYL ISOSTEARATEARATE, CAPRICILIC/CAPRIC TRIGLYCERIDE, PolyMethyl Methacrylate, T Ocopherol, Xanthan Gum, Carbonier, Triethanoiamine, Diazolidinyl Urea, Methylparaben, Propylparaben, Disodium Edta, Citric Acid, Parfum.

Serum with natural antioxidant resveratrol AMPOULE Effecter.

It stimulates collagen synthesis, prevents loss of elasticity, improves skin tone and elasticity. Ingredients: Aqua (Water), Niacinamide, Glycerin, Propylene Glycol, Ethylhexyl Stearate, Cyclomethicone, Dimethicone/Vinyl Dimethicone Crosspolymer, Dimethicone, Isohexadecane, Cetearyl Methicone, Xylitylglucoside, Anhydroxylitol, Xylitol, Polymethyl Methacrylate, Picea Mariana bark Extract (source PECBEPATPOJIA), Allantoin, Carbomer, Xanthan Gum, Parfum, Triethanolamine, Diazolidinyl Urea, Methylparaben, Propylparaben.

Facial serum Novosvit Concentrate 3D Hyaluronic acid & niacinamide.

The serum contains 3D hyaluronic acid, which provides deep hydration to the skin, saturating it with moisture. Used as a stand-alone product, or in combination with a mask or cream. Ingredients: Aqua (Water), Sodium Hyaluronate, Glycerin, Betaine, Niacinamide, Xylitylglucoside, Anhydroxylitol, Xylitol, Holymethylsilsesquioxane, Dimethicone, Isohexadecane, Cetearyl Methicone, Peg-40 Stearate, Steareth-2, Steareth-21, Xanthan Gum, Sodium Polyacrylate, Disodium Edta, Citric Acid, Propylene Glycol, Diazolidinyl Urea, Methylparaben, Propylparaben.

The closest in purpose, composition and properties is the object described in patent RU No. 2376982, publ. 12/27/2009), - VITA moisturizing facial serum with anti-aging properties.

Moisturizing facial serum contains a gel-forming component, a moisturizing component glycerin, propylene glycol, triethanolamine, a preservative, fragrance, dietary supplement, as a dietary supplement - a suspension of niosomes up to 100 nm in size with included pig placenta stem cell extract, hyaluronic acid, oil avocado, a concentrate (Actiflow™) containing polysaccharides and vitamin PP, and the base includes an acrylate copolymer emulsion (Salcare SC80), silicone elastomer (DC 9045), cyclomethicone DC 345 and melt water from the glaciers of the North Caucasus mountains.

The claimed object is a rejuvenating serum based on hyaluronic acid and collagen (2 options).

The proposed serum expands the arsenal of cosmetic anti-aging products, which is especially important in cosmetology at the present time.

Serum is a special cosmetic product of liquid consistency, which is intended for additional care of the skin of the face, neck and décolleté. The composition of the serum is a mixture of active substances, the concentration of which is 8-10 times higher than in any other cosmetic product.

Penetrating into the skin, the active components begin to act in the deepest layers of the skin, thereby providing a pronounced cosmetic and therapeutic effect. Serums, due to a more advanced chemical formula, make these components more stable than if they were placed, for example, in a cream. In serum, they are much less destroyed upon contact with air and interact more effectively with each other.

The inventive serum (option 1) has the following composition, wt.%:

Hyaluronic acid (high molecular weight) 0.1 -1.0

Sodium hyaluronate (low molecular weight) 0.4-1.0

Animal and/or plant collagen 0.5-1.0

Optifen 0.5-1.0

Purified water / water for injection 96.0 - 98.5

Sodium hydroxide 1 M solution to pH 5.0 - 8.0

The inventive serum (option 2) has the following composition, wt.%:

Hyaluronic acid (high molecular weight) 0.1 -1.0

Sodium hyaluronate (low molecular weight) Animal and/or plant collagen Glycerol Aloe Vera Extract Optifen Purified water/water for injection Sodium hydroxide 1 M solution 0.5 -1.0 0.4 -1.0 1.0 - 3.0 0.05 - 2.0 0.5 -1.0 91.0 - 97.45 up to pH 5.0 - 8.0

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Claims (2)

Due to its properties, hyaluronic acid or sodium hyaluronate (high molecular weight/low molecular weight) penetrates into the deeper layers of the skin without remaining on the surface, helps produce collagen and elastin, promotes skin rejuvenation, smooth out wrinkles, heal wounds, forms a thin barrier film on the surface of the skin, which retains moisture in the skin, protecting against dehydration and UV radiation. Animal (plant) collagen increases firmness and elasticity, has plasticizing, smoothing properties, reduces skin flaking, and relieves skin irritation. Plant collagen works at the level of the epidermis, i.e. on the surface of the skin, moisturizing it and maintaining the water-lipid balance, and marine - both on the surface and in the deep layers at the level of the dermis, regenerating and restoring damaged tissues and skin cells, reduces the number of freckles and age spots. Optifen is a preservative that allows the serum to retain its functional properties for a long time; in addition to preservative properties, it has softening and moisturizing properties. Purified water/water for injection serves as a diluent for the serum ingredients. Unimolar sodium hydroxide adjusts the pH of the serum medium to a physiologically comfortable one, has a strong bactericidal effect, and is a preservative. Aloe Vera extract: the polysaccharides contained in the composition provide a moisturizing effect, the resulting polysaccharide film actively attracts water molecules, while preventing the evaporation of moisture, has an anti-inflammatory effect, is excellent for problem skin, removes oily shine, acne and heals the facial skin, stimulates the activity of fibroblasts , helps increase the production of collagen and elastin fibers, makes the skin elastic, slows down the aging process and smoothes out existing wrinkles, lightens existing dark spots. Aloe vera treats frostbite, burns, including sunburn, neutralizes inflammation, and relieves itching. Polysaccharides and flavonoids in the plant gel restore the skin and promote the creation of new dermal cells. The zinc in aloe acts as an astringent to tighten pores, and antioxidants like vitamins C and E. The salicylic acid in aloe vera juice gently exfoliates dead skin cells. Leaves skin soft and silky. Aloe also contains lingin, which enhances the penetration of other beneficial components into the skin. The claimed serum is characterized by a light texture, it enhances the protective functions of the skin, stimulates collagen synthesis, smoothes expression lines and age-related wrinkles, moisturizes, prevents loss of elasticity, increases skin tone and elasticity, restores the clarity of facial contours, helps prevent the appearance of age spots and skin defects. Taking into account the state of the environment, water quality and stress, the serum can be used from the age of 20-25 to maintain its condition; after 25 years, when the aging process of the skin is activated, its use will ensure the prevention of age-related changes and help maintain youth. After 30-35 years, the skin especially needs careful care, so it is recommended, in addition to creams, masks and salon treatments, to use it daily. The use of the serum is indicated for dry, dehydrated and withered epidermis, with increased activity of the sebaceous glands, with increased skin sensitivity, the appearance of signs of photoaging, and the presence of fine wrinkles. The serum should be applied to the face, neck and décolleté after cleansing the skin. The delicate texture of the serum is quickly absorbed, leaving no feeling of stickiness or film effect. The contents of the bottle (ampoule) should be preheated in your hands and applied with massage movements. Gently press the remaining product into the skin using light pressure. The serum can be used as a stand-alone product or added to masks and creams to enhance the effect. If you are hypersensitive to the components of the serum, use should be discontinued. To achieve maximum effectiveness, the serum is used in courses 1-4 times a year. One course lasts from 2 weeks to 2 months. With regular use, the serum reduces the severity of wrinkles and increases the firmness and elasticity of the epidermis. CLAIM 1. Anti-aging serum based on hyaluronic acid and collagen, including hyaluronic acid, a preservative and water, characterized in that it contains high molecular weight hyaluronic acid, additionally animal and/or plant collagen, low molecular weight sodium hyaluronate, and optifen and sodium hydroxide as a preservative 1 M solution, purified water and/or water for injection in the following ratio of components, wt.%: hyaluronic acid (high molecular weight) - 0.1-1.0; sodium hyaluronate (low molecular weight) - 0.4-1.0; animal and/or growth collagen - 4 043462 body - 0.5-1.0; optifen - 0.5-1.0; purified water/water for injection - 96.0-98.5; sodium hydroxide 1 M solution - up to pH 5.0-8.0. 2. Rejuvenating serum based on hyaluronic acid and collagen, including hyaluronic acid, glycerin, preservative and water, characterized in that it contains high molecular weight hyaluronic acid, additionally animal and/or plant collagen, Aloe Vera extract, low molecular weight sodium hyaluronate, and as a preservative, optifen and sodium hydroxide 1 M solution, purified water and/or water for injection in the following ratio of components, wt.%: hyaluronic acid (high molecular weight) - 0.1-1.0; sodium hyaluronate (low molecular weight) - 0.5-1.0; animal and/or vegetable collagen - 0.4-1.0; glycerin - 1.0-3.0; Aloe Vera extract - 0.05-2.0; optifen - 0.5-1.0; purified water/water for injection - 91.0-97.45; sodium hydroxide 1 M solution - up to pH 5.0-8.0. Eurasian Patent Organization, EAPO Russia, 109012, Moscow, Maly Cherkassky lane, 2