EA040410B1 - FUNGICIDAL COMPOSITION - Google Patents

Description

Technical field

The present invention relates to the field of crop protection, in particular to a fungicidal composition with improved properties, and in particular to a fungicidal composition comprising benzisothiazolinone and flutriafol.

State of the art

Benzisothiazolinone compounds are a new broad-spectrum fungicide, which is mainly used to control the spread and treat various bacterial and fungal diseases of cereals, vegetables and fruits. Mechanisms of fungicidal action include destruction of the structure of the nuclei of harmful fungi, which causes their death due to the loss of the main component, and interference with the metabolism of fungal cells, which causes a physiological disorder, eventually leading to death. If the agent is used in the early stages of disease development, plants can be effectively protected from pathogen infestation, but when the agent is used in an appropriately increased amount in advanced disease, the spread of harmful fungi is greatly controlled and thus the double action of protection and eradication is performed.

Flutriafol is a broad spectrum systemic fungicide used to protect and treat various diseases caused by basidiomycetes and marsupials and is effective in controlling powdery mildew, rust fungi, black fungus in wheat, maize, etc. The main mechanism of action is based on the inhibition of the biosynthesis of ergosterol (provitamin D2) and thus causes the destruction of the walls of fungal cells, as well as inhibition of mycelial growth. Flutriafol is also a fungicide with eradication, protective, contact poisoning and systemic activities. Flutriafol is used to protect and treat various diseases caused by basidial and marsupial fungi, it also has a fumigation effect, but is not active against oomycetes and bacteria. This agent has a good systemic effect and can be absorbed through the roots, stems and leaves of plants, and then transmitted upward through capillary channels. Systemic action through the roots is more significant than through the stems and leaves. In this case, horizontal transfer or transfer from the phloem down is impossible. Thus, flutriafol can inhibit the growth of fungi inside or outside plants. Flutriafol is capable of eradicating powdery mildew spores, which threaten wheat crops, within 5-10 days after application, while previously formed spots disappear.

Practical experience in the field of pesticides has shown that the repeated and specific use of an active ingredient for the control of harmful fungi leads in many cases to a rapid selectivity of fungal strains. To reduce the risk of selectivity of resistant fungal strains, a mixture of substances with different activities is currently commonly used to control the spread of harmful fungi. By combining active ingredients with different mechanisms of action, it becomes possible to delay the development of resistance, reduce application rates and reduce costs.

Brief description of the invention

In view of the problem of development of resistance and retention of residues in the soil, which are encountered in the practical application of fungicides, the object of the present invention is the screening of fungicides with different mechanisms of bacterial action, which are combined to create a new fungicidal composition in order to increase the spread control effect exhibited by bactericides, postpone development of resistance, reduce application rate and reduce cost.

Another object of the present invention is to provide a method for preparing a fungicidal composition consisting of active ingredients A and B and using the above to control the spread of crop pests in agriculture.

The objects of the present invention can be realized through the following measures.

The fungicidal composition having a synergistic effect combines active components A and B, wherein the active component A is benzisothiazolinone and the active component B is flutriafol.

The authors experimentally determined that the composition of this invention has a clear synergistic effect on the control of the spread of bacterial or fungal diseases of cereals, while, more importantly, the application rate is reduced, as well as the cost. The substances that make up components A and B have different structures and different mechanisms of action, and the combination of the two substances can expand the spectrum of fungicidal activity and, to a certain extent, reduce the prevalence and development of resistance of fungi. Moreover, there is no cross-resistance between components A and B.

The weight ratio between the two components of this invention is 1:30-30:1. In a preferred embodiment of the invention, the weight ratio between the active ingredient A and the active ingredient B is 1:20-20:1, even more preferably the weight ratio is 1:10-10:1 to achieve the best effect.

In certain embodiments, components A and B may be in any defined

- 1040410 ratios such as 30:1, 29:1, 28:1, 27:1, 26:1, 25:1, 24:1, 23:1, 22:1, 21:1, 20:1 , 19:1, 18:1, 17:1, 16:1,

15:1, 14:1, 13:1, 12:1, 11:1, 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3: 1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9,

1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1:19, 1:20, 1:21, 1: 22, 1:23, 1:24, 1:25, 1:26, 1:27, 1:28, 1:29, and 1:30, or the ratio may be selected from a range limited to any two of the above.

The composition of the present invention may be in the composition of a pesticidally acceptable composition containing active ingredients and additionally containing pesticide auxiliary additives or adjuvants. The composition, which is part of a pesticidally acceptable composition, contains 4-80 wt.% active ingredients and 96-20 wt.% pesticide adjuvant.

The present invention provides for the use of a bactericidal composition consisting of components A and B, controlling the spread of diseases of cereals in agriculture, in particular controlling fungal and bacterial diseases of certain cereals.

The composition may specifically contain a pesticidal adjuvant such as one or more of carriers, solvents, dispersants, wetting agents, binders, thickeners, adhesives, surfactants, fertilizers, and the like. The commonly used adjuvant may be admixed during use.

A suitable adjuvant or additive may be a solid or liquid, which are typically materials commonly used in formulations, eg natural or regenerated minerals, solvent, dispersing agent, wetting agent, adhesive, thickener, binder.

The composition of the present invention can be applied to the application of the composition of the present invention to the aerial parts of plants, in particular leaves and, accordingly, leaf surfaces. The composition can be used to impregnate seeds, or be applied to the surface of controlled objects. The frequency and dosage of application depend on the biology of the pathogen and the climatic and environmental conditions. The place where a particular plant grows, such as a rice field, can be soaked in a liquid form of the composition, or the composition can be introduced in solid form into the soil, for example in the form of granules (soil application), while the composition penetrates the plant through the roots from the soil ( system action).

The composition of the present invention may be formulated into various pesticidally acceptable compositions, including, but not limited to, emulsifiable concentrates, aqueous emulsions, microemulsions, baits, mother liquor, mother powder, etc. In a preferred embodiment, the composition of the present invention is an aqueous solution, suspension, dispersible powder, water-dispersible granules or microemulsion. Depending on the composition, it is intended to achieve the objectives through the use of the compositions; depending on the environmental conditions, the compositions can be applied by spraying, atomizing, spraying, dispersing or pouring.

The composition of the present invention can be prepared in various compositions using known methods. The active ingredients may be uniformly mixed with adjuvants such as a solvent or solid carrier or surfactant, if necessary, and milled to prepare the desired formulation.

The solvent may be selected from aromatic hydrocarbons containing preferably from 8 to 12 carbon atoms, for example mixtures of xylenes, substituted benzene or phthalic ether, for example dibutyl or dioctyl phthalate;

aliphatic hydrocarbons, for example cyclohexane or paraffin, alcohols, glycols, ethers and esters, for example ethanol, ethylene glycol, ethylene glycol monomethyl ether;

ketones, for example cyclohexanone;

highly polar solvents, for example K-methyl-2-pyrrolidone, dimethylsulfoxide or dimethylformamide; as well as vegetable oils, such as soybean oil.

The solid carrier, for example, includes natural mineral fillers commonly used as powders or dispersing agents, such as talc, kaolin, monmorillonite, or activated bauxite. In order to control the physical properties of the composition, highly dispersed silicic acid or a highly dispersed polymeric adsorbent carrier, such as a granular adsorbent carrier or a non-absorbent carrier, can also be added. A suitable granular adsorbent carrier is a porous material such as pumice, oily clay or bentonite. A suitable non-absorbent agent is, for example, calcite or sand. Moreover, a wide range of inorganic or organic materials which are preformed in the form of granules, in particular dolomite, can be used as a carrier.

According to the chemical nature of the active components of the composition of the present invention, suitable surfactants include lignosulfonic acid, naphthalene sulfonic acid, phenolsulfonic acid, alkaline earth metal salts or amine salts, alkylaryl sulfonates, alkyl sulfates, alkyl sulfonates, fatty alcohol sulfates, fatty acids, and ethylene glycol ethers. and sulfonated fatty alcohols, condensation products of sulfonated naphthalene and naphthalene derivatives with formaldehyde, condensation products of naphthalene or naphthalene sulfonic acids with phenol and formaldehyde, polyoxoethylene octylphenyl ethers, tributylphenyl polyethylene glycol ether, tristearylphenyl polyethylene glycol ether, alkylaryl polyester alcohols, ethoxylated castor alkyl ether products, polyoxyethylene ethers ethylene oxide condensations, ethoxylated polyoxypropylene, polyethylene glycol ether laurate acetal, sorbates, liquid lignin sulfite residues, and methylcellulose.

When preparing a liquid composition, the active component A may first be dissolved in the base material, thus forming a metal salt of benzisothiazoline. Suitable base materials include alkali metal carbonates, alkali metal hydroxides (eg sodium hydroxide and potassium hydroxide), alkali metal alkoxycarbonates, alkali metal alkoxides or magnesium methoxide.

The two active components of the composition of the present invention have a synergistic effect, which is that the activity of the composition is obviously higher than the corresponding activity or the estimated sum of the respective activities of the individual components. The synergistic effect is manifested as a reduced application rate, an expanded spectrum of fungicidal activity, an accelerated onset of action, a longer effect on control of spread, better control of harmful fungi on plants in the case of one or more applications, and an expanded range of possible applications. These qualities are especially necessary in the practice of controlling fungal infections of plants.

The fungicidal composition of the present invention is useful in controlling the spread of diseases of cereals in agriculture, and the specific diseases that are supposed to be cured include, but are not limited to, bacterial hole spot of peach, tobacco grouse, rice rhizoctoniosis, angular leaf spot of cucumbers, downy mildew of cucumbers, bacterial leaf streak of rice, bacterial root rot of rice, bacterial wilt of cereals, usariose wilt of watermelon, downy mildew of grapes, bacterial wilt of tomatoes, bacterial wilt of eggplant, downy smut of rice, bacterial leaf streak of rice, anthracnose of pepper, blight of lychee, anthracnose of grapes, bacterial wilt tobacco, cucumber anthracnose, celery leaf spot, lotus root rot, strawberry powdery mildew, lettuce downy mildew, celery gray mold, apricot bacterial hole spot, peach blight, onion downy mildew, corn bug cotton leaf spot, cucumber leaf spot, etc.

The composition of the present invention exhibits the following additional features.

1. The composition of the present invention has a clear synergistic effect.

2. Due to the fact that the two individual agents in the composition of the present invention have very different structures and completely different mechanisms of action, there is no cross-resistance, which eliminates the problem of resistance development resulting from the use of only one agent.

3. The composition of the present invention is safe for cereals and has high efficiency.

Tests confirm that the fungicidal composition of the present invention has stable chemical properties, significant synergistic effect, and obvious synergistic and complementary effects on controlled objects.

Detailed description of the invention

In order to clarify the objects, technical solution and advantages of the present invention, the present invention will now be described in more detail with examples. It should be understood that the specific examples described herein are provided for illustration only and do not limit the present invention. Any modifications and equivalent improvements and substitutions may be made without departing from the spirit and principle of the present invention; they all fall within the scope of legal protection of the present invention.

In all of the formulation examples below, percentages are expressed as weight percent. Various formulations are made from the composition of the present invention using previously known methods, which may vary as desired.

I. Examples of preparation of compositions.

(I) Preparation and examples of wettable powder.

To prepare a wettable powder, active ingredients A and B and various additives and excipients are thoroughly mixed in appropriate proportions and ground using an ultra-fine grinder.

Example 1 Wettable Powder 52% Benzisothiazilinone Flutriafol.

Benzisothiazolinone - 2%; flutriafol - 50%; nekal - 5%; bentonite - 3%; a simple ether of alkyl polyoxyethylene sulfonate - 4%; white soot - 5%, diatomaceous earth - up to 100%.

Example 2 Wettable Powder 44% Benzisothiazilinone Flutriafol.

Benzisothiazolinone - 4%; flutriafol - 40%; sodium lignosulfonate - 5%; alkyl ether of lyoxyethylene sulfonate - 3 040410 6%; white soot - 10%, diatomaceous earth - up to 100%.

Example 3 12% benzisothiazilinone-flutriafol wettable powder.

Benzisothiazolinone - 10%; flutriafol - 2%; sodium lignosulfonate - 5%; alkyl sulfonate - 5%;

white soot - 10%; kaolin - up to 100%.

Example 4 Wettable Powder 64% Benzisothiazilinone Flutriafol.

Benzisothiazolinone - 60%; flutriafol - 4%; oily clay - 3%; alkyl sulfonate - 5%; white soot - 5%; diatomaceous earth - up to 100%.

Example 5 Wettable Powder 31% Benzisothiazilinone Flutriafol.

Benzisothiazolinone - 30%; flutriafol - 1%; sodium benzoate - 5%; a simple ether of alkyl polyoxyethylene sulfonate - 6%; white soot - 10%; kaolin - up to 100%.

(II) Preparation and examples of suspensions.

Active ingredients A and B are uniformly mixed with a dispersing agent, wetting agent, thickener, water and other components in appropriate proportions, crushed and/or high-speed grinding, obtaining an intermediate, which is analyzed, diluted with water, uniformly mixed, filtered and the final product is obtained.

Example 6 Suspension of 15.5% benzisothiazolinone-flutriafol.

Benzisothiazolinone - 0.5%; flutriafol - 15%; white soot - 5%; ethylene glycol - 5%; polyoxyethylene fatty alcohol phosphate ether - 6%; water - up to 100%.

Example 7 Suspension of 32% benzisothiazolinone-flutriafol.

Benzisothiazolinone - 2%; flutriafol - 30%; white soot - 3%; glycerin - 4%; sodium benzoate - 2%; condensation product of sodium methylnaphthalenesulfonate and formaldehyde - 5%; water - up to 100%.

Example 8 Suspension of 10% benzisothiazolinone-flutriafol.

Benzisothiazolinone - 5%; flutriafol - 5%; bentonite - 4%; ethylene glycol - 5%; sodium benzoate - 7%; xanthan gum - 2%; water - up to 100%.

Example 9 Suspension of 21% benzisothiazolinone-flutriafol.

Benzisothiazolinone - 20%; flutriafol - 1%; white soot - 3%; glycerin - 5%; sodium lignosulfonate - 4%; condensation product of sodium methylnaphthalenesulfonate and formaldehyde - 5%; water - up to 100%.

(III) Preparation and examples of water-dispersible granules.

The active ingredients A and B, the adjuvant and the excipient are uniformly mixed according to the composition ratios, finely ground with a gas flow to obtain a wettable powder, some water is added, mixed, compressed, granulated, dried, sieved, and the product is obtained as water-dispersible granules.

Example 10 10.5% benzisothiazolinone-flutriafol water-dispersible granules.

Benzisothiazolinone - 0.5%; flutriafol - 10%; potassium dodecylsulfonate - 5%; ammonium sulfate - 5%; potassium alkylnaphthalenesulfonate - 4%; finely ground calcium carbonate - up to 100%.

Example 11 30% benzisothiazolinone-flutriafol water-dispersible granules.

Benzisothiazolinone - 5%; flutriafol - 25%; condensation product of sodium methylnaphthalenesulfonate and formaldehyde - 5%; sodium dodecyl sulfate - 3%; sodium lignosulfonate - 6%; diatomaceous earth - up to 100%.

Example 12 Benzisothiazolinone-flutriafol 22% water-dispersible granules.

Benzisothiazolinone - 20%; flutriafol - 22%; potassium dodecyl sulfate - 3%; ammonium sulfate - 5%; condensation product of sodium methylnaphthalenesulfonate and formaldehyde - 5%; finely ground calcium carbonate - up to 100%.

Example 13 52% benzisothiazolinone-flutriafol water-dispersible granules.

Benzisothiazolinone - 50%; flutriafol - 2%; condensation product of sodium methylnaphthalenesulfonate and formaldehyde - 5%; sodium dodecyl sulfate - 5%; ammonium sulfate - 5%; diatomaceous earth - up to 100%.

II. Research to test effectiveness.

(I) Examples of bioassays.

Based on the grading scale, studies study the development of the disease on the leaves of the whole cucumber plant and calculate the disease index and the spread control effect.

The spread control effect is converted to a probability (y), the concentration of agents (µg/mL) in solution is converted to a logarithmic value (x), the toxicity regression equation and the median inhibition concentration EC50 are calculated by the least squares method, and the toxicity index and cotoxicity coefficient (CTC) of the agents are calculated Pei Yun Sun's method.

Actual Toxicity Index (ATI)=(EC50 standardα/EC50 of test agent)x100 Theoretical Toxicity Index (TTI)=Agent Toxicity Index Aχpercentage of A in the mixture+toxicity index of the agent Bχnpercentage of B in the mixture Cotoxicity Coefficient (CTC)=[actual toxicity index (ATI) mixtures/theoretical toxicity index (TTI) mixtures] x 100

At CTC<80 the composition exhibits an antagonistic effect, at 80<CTC<120 the composition exhibits an additive effect, and at CTC>120 the composition exhibits a synergistic effect. Toxicity test for benzisothiazolinone mixed with flutriafol.

Table 1 Results of analysis of the toxicity study of benzisothiazolinone in combination with flutriafol on wheat leaf rust

Agent name EC50 (mcg/ml) ATI TTI Sotoxicity coefficient (CTC) Flutriafol 67.34 100.00 \ \ Benzisothiazo lino n 40.23 167.39 \ \ Benzisothiazolinone: flutriafol 1:30 53.25 126.45 102.17 123.76 Benzisothiazolinone: flutriafol = 1:25 AM 52.15 129.13 102.59 125.87 Benzisothiazolinone: flutriafol = 1:20 AM 48.61 138.54 103.21 134.23 Benzisothiazolinone: flutriafol = 1:15 AM 46.94 143.47 104.21 137.67 Benzisothiazolinone: flutriafol = 1:10 AM 42.85 157.16 106.13 148.09 Benzisothiazolinone: flutriafol =1:5 40.30 167.10 111.23 150.23 Benzisothiazolinone: flutriafol =1:1 33.02 203.94 133.69 152.54 Benzisothiazolinone: flutriafol = 5:1 28.56 235.76 156.16 150.98 Benzisothiazolinone: flutriafol = 10:1 28.11 239.57 161.26 148.56 Benzisothiazolinone:flutriafol = 15:1 29.91 225.15 163.18 137.98 Benzisothiazolinone: flutriafol = 20:1 30.33 222.02 164.18 135.23 Benzisothiazolinone: flutriafol = 25:1 32.19 209.21 164.80 126.95 Benzisothiazolinone: flutriafol = 30:1 32.85 204.98 165.21 124.07

The results (Table 1) show that for benzisothiazolinone and flutriafol, the effect of controlling the spread of wheat leaf rust is significantly improved, confirming the remarkable synergistic effect of the combination of these two components in controlling the spread of wheat leaf rust. Experiments show that if the ratio of benzisothiazolinone and flutriafol is outside the limits defined by this study, the cotoxicity coefficient is below 120.

(II) Field study to test effectiveness.

Research method. At an early stage in the development of the disease, the first spray is carried out immediately, and then the second application is carried out after 7 days. Each treatment covers 4 experimental plots of 20 m ² each. The development of the disease before application and 11 days after the second application is examined statistically. Samples were randomly collected from 5 sites of each test site and 5 plants from each site were examined to determine the percentage of disease spot area on the leaves relative to the leaf area of the whole plant, and classified. The disease index and spread control effect are calculated.

„ / Number of leaves in each Typical value \

Disease Index=

X degree of development of the disease of the corresponding degree

Total number Typical value x of the examined leaves of the highest degree x100' Disease index in the control Index of the disease in the treated ^

Spread control effect (%)=

1 group before application group after application

Disease index in the control Index of disease in the treated *100 group after application group before application

Estimated spread control effect (%)=X + Y - XY/100 where X and Y represent the spread control effects for a single agent. Classification scale.

Grade 0: no disease spots;

Grade 1: number of disease spots per leaf < 5 with length < 1 cm;

- 5 040410 grade 3: 6 < number of disease spots per leaf <10 with some disease spots >1 cm long;

grade 5: 11 < number of disease spots per leaf <25, some disease spots are extended, and the area of disease spots is 10-25% of the leaf area;

grade 7: the number of disease spots per leaf >26, the disease spots are extended, and the area of the disease spots is 26-50% of the leaf area;

grade 9: disease spots are extended, the area of disease spots is more than 50% of the leaf area, or all leaves are wilted.

(III) Field study of the efficacy of benzisothiazolinone in combination with flutriafol.

Table 2 __________ Control effect of strawberry powdery mildew __________

no. Agent Quantity (mg/kg) Disease index before application Day 11 after second application Disease index Spread control effect (%) Example 1 3% benzo isothiazolinone wettable powder 4.6 15.36 30.55 6.07 50% flutriafol wettable powder 115.4 14.98 11.23 64.58 Estimated spread control effect after mixing them - - - 66.73 52% benzisothiazolinone • flutriafol wettable powder (benzisothiazolinone: flu triafol =1:25) 120 16.02 9.82 71.05

- 6 040410

Example 2 3% benzoisothiazolinone wettable powder 10.9 14.78 28.26 9.69 80% flutriafol wettable powder 109.1 14.56 11.99 61.11 Estimated spread control effect after mixing them 64.88 44% benzisothiazolinone •flutriafol wettable powder (benzisothiazolinone: flutriafol =1:10 AM) 120 16.21 7.51 78.11 Example 3 3% benzoisothiazolinone wettable powder 100.0 13.98 11.96 59.61 50% flutriafol wettable powder 20.0 14.03 26.10 12.13 Estimated spread control effect after mixing them 64.51 12% benzisothiazolinone •flutriafol wettable powder (benzisothiazolinone: flutriafol =5:1) 120 17.32 7.97 78.28 Example 4 3% benzoisothiazolinone wettable powder 112.5 10.78 7.58 66.81 50% flutriafol wettable powder 7.5 16.43 32.97 5.23 Estimated spread control effect after mixing them 68.55 64% benzisothiazolinone • flutriafol wettable powder (benzisothiazolinone: flu triafol =15:1) 120 11.37 5.40 77.57 3% benzoisothiazolinone wettable powder 116.1 10.77 7.17 68.56 80% flutriafol wettable powder 3.9 12.34 25.28 3.25

- 7 040410

Estimated spread control effect after mixing them 69.58 31% benzisothiazolinone • flutriafol wettable powder (benzisothiazolinone: flutriafol =30:1) 120 15.04 8.58 73.07 3% benzisothiazolinone suspension 3.9 12.22 24.38 5.78 25% flutriafol suspension 116.1 15.34 11.29 65.24 Estimated spread control effect after mixing them 67.25 15.5% benzisothiazolinone •flutriafol, suspension (benzisothiazolinone: flutriafol =1:30) 120 16.03 9.90 70.82 3% benzisothiazolinone suspension 7.5 13.98 27.29 7.81 40% flutriafol suspension 112.5 14.34 11.24 62.99 Estimated spread control effect after mixing them 65.88 32% benzisothiazolinone • flutriafol, suspension (benzisothiazolinone: flutriafol = 1:15 120 15.67 8.34 74.85 3% benzisothiazolinone suspension 60.0 15.78 20.98 37.22 40% flutriafol suspension 60.0 15.33 21.37 34.15 Estimated spread control effect after mixing them 58.66

- 8 040410

10% benzisothiazolinone • flutriafol, suspension (benzisothiazolinone: flutriafol = 1:1) 120 10.89 6.12 73.44 Example 9 3% benzisothiazolinone suspension 114.3 10.34 7.10 67.59 40% flutriafol suspension 5.7 14.98 30.37 4.25 Estimated spread control effect after mixing them 68.97 21% benzisothiazolinone • flutriafol, suspension (benzisothiazolinone: flutriafol = 20:1) 120 14.44 6.88 77.50 Example 10 3% benzisothiazolinone, water-dispersible granules 5.7 15.87 31.28 6.92 35% flutriafol, water-dispersible granules 114.3 16.39 12.51 63.95 Estimated spread control effect after mixing them 66.44 10.5% benzisothiazolinone •flutriafol, water-dispersible granules (benzisothiazolinone: flutriafol =1:20) 120 10.74 5.74 74.76 Example 11 3% benzisothiazolinone, water-dispersible granules 20.0 13.77 24.84 14.79 20% flutriafol, water-dispersible granules 100.0 15.98 14.85 56.12 Estimated spread control effect after mixing them 62.61

-

Claims (9)

SC Example 12 Example 13 30% benzisothiazolinone • flutriafol, water-dispersible granules (benzisothiazolinone: flutriafol =1:5) 120 16.22 8.04 76.59 3% benzisothiazolinone, water-dispersible granules 109.1 15.09 11.27 64.72 20% flutriafol, water-dispersible granules 10.9 10.78 21.20 7.14 Estimated spread control effect after mixing them 67.24 22% benzisothiazolinone • flutriafol, water-dispersible granules (benzisothiazolinone: flutriafol = 10:1) 120 15.23 6.33 80.36 3% benzisothiazolinone, water-dispersible granules 115.4 16.89 11.35 68.27 35% flutriafol, water-dispersible granules 4.6 15.34 31.30 3.64 Estimated spread control effect after mixing them 69.42 52% benzisothiazolinone • flutriafol, water-dispersible granules (benzisothiazolinone: flutriafol = 25:1) 120 16.67 9.28 73.69 Water control - 15.42 32.65 - The results of the studies (Table 2) show that the effect of controlling the spread of strawberry powdery mildew is significantly improved when using the combination of benzisothiazolinone with flutriafol, which confirms the significant synergistic effect of this combination of two components in controlling the spread of strawberry powdery mildew. CLAIM 1. A fungicidal composition comprising active ingredients consisting of two active ingredients A and B, where the active ingredient A is benzisothiazolinone and the active ingredient B is flutriafol, and the mass ratio of the two components is 1:30-30:1. 2. Fungicidal composition according to claim 1, characterized in that the mass ratio of the active component A and the active component B is 1:20-20:1. 3. Fungicidal composition according to claim 2, characterized in that the mass ratio of the active component A and the active component B is 1:10-10:1. 4. A fungicidal composition according to any one of claims 1 to 3, characterized in that it is in the composition of a pesticidally acceptable composition further containing a pesticidal adjuvant or additive. 5. A fungicidal composition according to claim 4, characterized in that it is in the composition of a pesticidally acceptable composition, where the specified pesticidally acceptable composition contains 4-80 wt.% of the specified active components and 96-20 wt.% of the specified pesticidal adjuvant. 6. A fungicidal composition according to claim 4, characterized in that the composition is wettable - 10 040410 powder, suspension or water-dispersible granules. 7. A fungicidal composition according to claim 4, characterized in that the pesticidal adjuvant or additive is one or more selected from carriers, solvent, dispersant, wetting agent, binder, thickener, adhesive, surfactant, and fertilizer. 8. The use of a fungicidal composition according to any one of claims 1 to 3 for the control of crop diseases in agriculture. 9. The use of a fungicidal composition according to any one of claims 1 to 3 for controlling wheat leaf rust or strawberry powdery mildew in agriculture. Eurasian Patent Organization, EAPO Russia, 109012, Moscow, Maly Cherkassky per., 2 -