EA039310B1 - Способы снижения сердечно-сосудистого риска - Google Patents
Способы снижения сердечно-сосудистого риска Download PDFInfo
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- EA039310B1 EA039310B1 EA201691847A EA201691847A EA039310B1 EA 039310 B1 EA039310 B1 EA 039310B1 EA 201691847 A EA201691847 A EA 201691847A EA 201691847 A EA201691847 A EA 201691847A EA 039310 B1 EA039310 B1 EA 039310B1
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| EP15305293 | 2015-02-26 | ||
| PCT/US2015/020564 WO2015142668A1 (en) | 2014-03-17 | 2015-03-13 | Methods for reducing cardiovascular risk |
Publications (2)
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| EA201691847A1 EA201691847A1 (ru) | 2017-01-30 |
| EA039310B1 true EA039310B1 (ru) | 2022-01-12 |
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| EA201691847A EA039310B1 (ru) | 2015-02-26 | 2015-03-13 | Способы снижения сердечно-сосудистого риска |
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| EP (2) | EP3119810B1 (enExample) |
| JP (3) | JP2017509624A (enExample) |
| KR (3) | KR20220157516A (enExample) |
| CN (3) | CN114642661A (enExample) |
| AU (3) | AU2015231713B2 (enExample) |
| CA (1) | CA2942549A1 (enExample) |
| EA (1) | EA039310B1 (enExample) |
| ES (1) | ES2978990T3 (enExample) |
| HU (1) | HUE066839T2 (enExample) |
| IL (1) | IL304491A (enExample) |
| MX (1) | MX380767B (enExample) |
| PL (1) | PL3119810T3 (enExample) |
| WO (1) | WO2015142668A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130064834A1 (en) | 2008-12-15 | 2013-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to pcsk9 |
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| LT2443246T (lt) | 2009-06-15 | 2018-03-26 | Amarin Pharmaceuticals Ireland Limited | Kompozicijos ir būdai, skirti trigliceridų sumažinimui, nepakeliant ldl-c lygio subjekte, kartu taikant statino terapiją |
| HRP20180959T1 (hr) | 2011-01-28 | 2018-07-27 | Sanofi Biotechnology | Ljudska protutijela za pcsk9 za uporabu u postupcima liječenja određenih skupina subjekata |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| CA2848201C (en) | 2011-09-16 | 2020-10-27 | Regeneron Pharmaceuticals, Inc. | Methods for reducing lipoprotein(a) levels by administering an inhibitor of proprotein convertase subtilisin kexin-9 (pcsk9) |
| US10111953B2 (en) | 2013-05-30 | 2018-10-30 | Regeneron Pharmaceuticals, Inc. | Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9) |
| CN111920954A (zh) | 2013-06-07 | 2020-11-13 | 再生元制药公司 | 通过施用pcsk9抑制剂抑制动脉粥样硬化的方法 |
| CN106062003A (zh) | 2013-11-12 | 2016-10-26 | 赛诺菲生物技术公司 | 用于与pcsk9抑制剂一起使用的给药方案 |
| CA2954767A1 (en) * | 2014-07-14 | 2016-01-21 | Amgen Inc. | Crystalline antibody formulations |
| KR20230007538A (ko) * | 2014-07-16 | 2023-01-12 | 사노피 바이오테크놀로지 | 고콜레스테롤혈증이 있는 심혈관 위험이 높은 환자를 치료하는 방법 |
| KR20170029613A (ko) | 2014-07-16 | 2017-03-15 | 사노피 바이오테크놀로지 | 이형접합성 가족성 고콜레스테롤혈증(heFH) 환자의 치료방법 |
| US10472424B2 (en) | 2014-09-23 | 2019-11-12 | Pfizer Inc. | Treatment with anti-PCSK9 antibodies |
| IL314925A (en) | 2015-08-18 | 2024-10-01 | Regeneron Pharma | Antibodies against PCSK9 for the treatment of patients with hyperlipidemia undergoing lipoprotein-lowering therapy |
| JOP20190112A1 (ar) * | 2016-11-14 | 2019-05-14 | Amgen Inc | علاجات مدمجة لتصلب الشرايين، شاملة مرض قلبي وعائي تصلبي |
| US10329620B2 (en) * | 2017-01-12 | 2019-06-25 | Cardioforecast Ltd. | Methods and kits for treating cardiovascular disease |
| KR102401796B1 (ko) | 2017-04-13 | 2022-05-25 | 카딜라 핼쓰캐어 리미티드 | 신규의 펩타이드 기재 pcsk9 백신 |
| EP3762026A1 (en) * | 2018-03-06 | 2021-01-13 | Sanofi Biotechnology | Use of pcsk9 inhibitor for reducing cardiovascular risk |
| JP7513533B2 (ja) * | 2018-07-02 | 2024-07-09 | アブセントラ，エルエルシー | リポタンパク質ａの形成を減少させるための組成物及び方法、ならびに大動脈弁硬化症及び大動脈弁狭窄症の治療 |
| EA202190547A1 (ru) * | 2018-08-17 | 2021-04-27 | Амарин Фармасьютикалз Айрлэнд Лимитед | Способы снижения потребности в реваскуляризации периферических артерий у субъекта, получающего лечение статинами |
| MA51766A (fr) | 2018-09-24 | 2020-12-16 | Amarin Pharmaceuticals Ie Ltd | Procédés de réduction du risque d'événements cardiovasculaires chez un sujet |
| DK3911648T3 (da) | 2019-01-18 | 2025-01-13 | Astrazeneca Ab | 6'-[[(1s,3s)-3-[[5-(difluormethoxy)-2-pyrimidinyl]amino]cyclopentyl]amino][1(2h),3'-bipyridin]-2-on som pcsk9-hæmmer og fremgangsmåder til anvendelse deraf |
| AU2020378424A1 (en) * | 2019-11-07 | 2022-06-23 | Medimmune, Llc | Endothelial lipase antibodies for the treatment of cardiovascular diseases |
| CN114980973A (zh) | 2019-11-12 | 2022-08-30 | 阿马里纳药物爱尔兰有限公司 | 降低心房纤颤和/或心房扑动受试者心血管事件风险的方法 |
| CA3160071A1 (en) * | 2019-11-18 | 2021-05-27 | Ad Pharmaceuticals Co., Ltd. | Anti-pcsk9 antibody and use thereof |
| AU2022263358A1 (en) | 2021-04-21 | 2023-11-30 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing the risk of heart failure |
| CN114848849B (zh) * | 2022-04-25 | 2023-11-17 | 南方科技大学 | Pcsk9蛋白抑制剂在治疗心血管疾病中的应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010077854A1 (en) * | 2008-12-15 | 2010-07-08 | Regeneron Pharamaceuticals, Inc. | High affinity human antibodies to pcsk9 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| HRP20180959T1 (hr) * | 2011-01-28 | 2018-07-27 | Sanofi Biotechnology | Ljudska protutijela za pcsk9 za uporabu u postupcima liječenja određenih skupina subjekata |
| JOP20200043A1 (ar) * | 2011-05-10 | 2017-06-16 | Amgen Inc | طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010077854A1 (en) * | 2008-12-15 | 2010-07-08 | Regeneron Pharamaceuticals, Inc. | High affinity human antibodies to pcsk9 |
Non-Patent Citations (5)
| Title |
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| Anonymous: "NCT01507831 on 2013_06_27: ClinicalTrials.gov Archive", 27 June 2013 (2013-06-27), XP055189981, Retrieved from the Internet: URL: https://clinicaltrials.gov/archive/NCT01507831/2013_06_27 [retrieved on 2015-05-19], brief summary; brief title; arm/group * |
| Anonymous: "NCT01663402 on 2014_03_11: ClinicalTrials.gov Archive", 11 March 2014 (2014-03-11), XP55189973, Retrieved from the Internet: URL: https://clinicaltrials.gov/archive/NCT01663402/2014_03_11 [retrieved on 2015-05-19], brief summary; brief title * |
| EVAN A. STEIN, GARY D. SWERGOLD: "Potential of Proprotein Convertase Subtilisin/Kexin Type 9 Based Therapeutics", CURRENT ATHEROSCLEROSIS REPORTS, SPRINGER US, NEW YORK, vol. 15, no. 3, 1 March 2013 (2013-03-01), New York, pages 1 - 14, XP055139364, ISSN: 1523-3804, DOI: 10.1007/s11883-013-0310-3 * |
| GREGORY G. SCHWARTZ, LAURENCE BESSAC, LISA G. BERDAN, DEEPAK L. BHATT, VERA BITTNER, RAFAEL DIAZ, SHAUN G. GOODMAN, CORINNE HANOTI: "Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: Rationale and design of the ODYSSEY Outcomes trial", AMERICAN HEART JOURNAL, ELSEVIER, AMSTERDAM, NL, vol. 168, no. 5, 1 November 2014 (2014-11-01), AMSTERDAM, NL , pages 682 - 689, XP002739740, ISSN: 0002-8703, DOI: 10.1016/j.ahj.2014.07.028 * |
| JAMES M. MCKENNEY, MICHAEL J. KOREN, DEAN J. KEREIAKES, CORINNE HANOTIN, ANNE-CATHERINE FERRAND, EVAN A. STEIN: "Safety and Efficacy of a Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 Serine Protease, SAR236553/REGN727, in Patients With Primary Hypercholesterolemia Receiving Ongoing Stable Atorvastatin Therapy", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, ELSEVIER, vol. 59, no. 25, 1 June 2012 (2012-06-01), pages 2344 - 2353, XP055049859, ISSN: 07351097, DOI: 10.1016/j.jacc.2012.03.007 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022141868A (ja) | 2022-09-29 |
| KR20160132459A (ko) | 2016-11-18 |
| MX380767B (es) | 2025-03-12 |
| EP4403213A2 (en) | 2024-07-24 |
| ES2978990T3 (es) | 2024-09-23 |
| IL304491A (en) | 2023-09-01 |
| KR20220157516A (ko) | 2022-11-29 |
| CA2942549A1 (en) | 2015-09-24 |
| EA201691847A1 (ru) | 2017-01-30 |
| JP2017509624A (ja) | 2017-04-06 |
| EP3119810A1 (en) | 2017-01-25 |
| US20220144969A1 (en) | 2022-05-12 |
| US20150284473A1 (en) | 2015-10-08 |
| AU2015231713B2 (en) | 2020-11-19 |
| KR20250006995A (ko) | 2025-01-13 |
| AU2024205254A1 (en) | 2024-10-03 |
| CN114558129A (zh) | 2022-05-31 |
| MX2016011975A (es) | 2016-12-05 |
| AU2021201118A1 (en) | 2021-03-11 |
| WO2015142668A1 (en) | 2015-09-24 |
| EP3119810C0 (en) | 2024-02-28 |
| EP4403213A3 (en) | 2024-10-23 |
| AU2015231713A1 (en) | 2016-10-20 |
| JP2024147744A (ja) | 2024-10-16 |
| PL3119810T3 (pl) | 2024-07-15 |
| CN114642661A (zh) | 2022-06-21 |
| EP3119810B1 (en) | 2024-02-28 |
| CN106794244A (zh) | 2017-05-31 |
| HUE066839T2 (hu) | 2024-09-28 |
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