EA037743B1 - Обнаружение микроскопических объектов в текучей среде - Google Patents
Обнаружение микроскопических объектов в текучей среде Download PDFInfo
- Publication number
- EA037743B1 EA037743B1 EA201892777A EA201892777A EA037743B1 EA 037743 B1 EA037743 B1 EA 037743B1 EA 201892777 A EA201892777 A EA 201892777A EA 201892777 A EA201892777 A EA 201892777A EA 037743 B1 EA037743 B1 EA 037743B1
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- Eurasian Patent Office
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- image data
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Classifications
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- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
- G03H1/04—Processes or apparatus for producing holograms
- G03H1/0443—Digital holography, i.e. recording holograms with digital recording means
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
- G01N15/0205—Investigating particle size or size distribution by optical means
- G01N15/0227—Investigating particle size or size distribution by optical means using imaging; using holography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
- G01N21/45—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods
- G01N21/453—Holographic interferometry
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/85—Investigating moving fluids or granular solids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
- G01N15/0205—Investigating particle size or size distribution by optical means
- G01N15/0227—Investigating particle size or size distribution by optical means using imaging; using holography
- G01N2015/0233—Investigating particle size or size distribution by optical means using imaging; using holography using holography
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1029—Particle size
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/103—Particle shape
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0378—Shapes
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- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
- G03H1/0005—Adaptation of holography to specific applications
- G03H2001/0033—Adaptation of holography to specific applications in hologrammetry for measuring or analysing
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
- G03H1/0005—Adaptation of holography to specific applications
- G03H2001/0033—Adaptation of holography to specific applications in hologrammetry for measuring or analysing
- G03H2001/0044—Adaptation of holography to specific applications in hologrammetry for measuring or analysing holographic fringes deformations; holographic sensors
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
- G03H1/04—Processes or apparatus for producing holograms
- G03H1/0443—Digital holography, i.e. recording holograms with digital recording means
- G03H2001/0447—In-line recording arrangement
Landscapes
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Computing Systems (AREA)
- Theoretical Computer Science (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Holo Graphy (AREA)
- Image Processing (AREA)
- Microscoopes, Condenser (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16175687.9A EP3260841B1 (de) | 2016-06-22 | 2016-06-22 | Detektion von mikroskopischen objekten in flüssigkeiten |
PCT/FI2017/050463 WO2017220860A1 (en) | 2016-06-22 | 2017-06-21 | Detecting microscopic objects in fluids |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201892777A1 EA201892777A1 (ru) | 2019-06-28 |
EA037743B1 true EA037743B1 (ru) | 2021-05-17 |
Family
ID=56203200
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201892777A EA037743B1 (ru) | 2016-06-22 | 2017-06-21 | Обнаружение микроскопических объектов в текучей среде |
Country Status (10)
Country | Link |
---|---|
US (1) | US11630420B2 (de) |
EP (1) | EP3260841B1 (de) |
KR (1) | KR102402198B1 (de) |
CN (1) | CN109477782A (de) |
AU (1) | AU2017281680B2 (de) |
CA (1) | CA3027810A1 (de) |
EA (1) | EA037743B1 (de) |
SG (1) | SG11201811309YA (de) |
WO (1) | WO2017220860A1 (de) |
ZA (1) | ZA201900411B (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108489872B (zh) * | 2018-03-23 | 2022-03-04 | 奥星制药设备(石家庄)有限公司 | 在线粒度监测方法和系统 |
EP3575773A1 (de) * | 2018-05-28 | 2019-12-04 | Universität für Bodenkultur Wien | Verfahren zur bestimmung einer dreidimensionalen partikelverteilung in einem medium |
WO2021011637A1 (en) * | 2019-07-15 | 2021-01-21 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Complex diversity for accurate phase retrieval with single-shot acquisition |
CN116026729B (zh) * | 2023-03-03 | 2024-03-15 | 浙江大学 | 一种基于数字同轴全息显微的便携式微塑料检测装置 |
CN116071689B (zh) * | 2023-03-07 | 2023-06-06 | 四川三思德科技有限公司 | 一种基于lora技术的水源地水质在线监测方法及系统 |
CN117233116B (zh) * | 2023-11-09 | 2024-02-02 | 江西鼎智检测有限公司 | 一种基于机器视觉的水质分析方法及系统 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2110697A1 (de) * | 2008-04-17 | 2009-10-21 | Ruprecht-Karls-Universität Heidelberg | Wellenfeldmikroskop mit Subwellenlängenauflösung und Verfahren zur Bearbeitung mikroskopischer Bilder zur Erkennung von Objekten mit Subwellenlängendimensionen |
WO2011049965A1 (en) * | 2009-10-20 | 2011-04-28 | The Regents Of The University Of California | Incoherent lensfree cell holography and microscopy on a chip |
WO2015166009A1 (fr) * | 2014-04-30 | 2015-11-05 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Procédé et système de détection d'au moins une particule dans un liquide corporel, et procédé associé de diagnostic de la méningite |
CN105547945A (zh) * | 2016-01-14 | 2016-05-04 | 天津大学 | 干涉粒子成像系统采样区内粒子的判别方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2450973C (en) | 2002-11-27 | 2013-06-11 | Dalhousie University | A method for tracking particles and life forms in three dimensions and in time |
KR20070030191A (ko) * | 2004-04-16 | 2007-03-15 | 디시이 아프릴리스, 인코포레이티드 | 홀로그래픽 매체의 보정피처를 이용한 홀로그래픽데이터저장시스템의 보정 |
EP2576805A1 (de) * | 2010-05-25 | 2013-04-10 | Arryx, Inc. | Vorrichtung für holographische fluktuationsmikroskopie und verfahren zur bestimmung der mobilität von partikel- oder zelldispersionen |
EP2985719A1 (de) * | 2014-08-15 | 2016-02-17 | IMEC vzw | System und Verfahren für Zellerkennung |
TWI557462B (zh) * | 2014-11-28 | 2016-11-11 | 台灣愛美科股份有限公司 | 自動聚焦系統與方法 |
KR101820563B1 (ko) * | 2014-12-31 | 2018-01-19 | 한국전자통신연구원 | 홀로그램 데이터 포맷과 홀로그래픽 비디오 시스템 장치 및 방법 |
US20170333903A1 (en) * | 2016-05-20 | 2017-11-23 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and Methods for Automated Single Cell Cytological Classification in Flow |
-
2016
- 2016-06-22 EP EP16175687.9A patent/EP3260841B1/de active Active
-
2017
- 2017-06-21 CN CN201780039197.1A patent/CN109477782A/zh active Pending
- 2017-06-21 KR KR1020197002096A patent/KR102402198B1/ko active IP Right Grant
- 2017-06-21 SG SG11201811309YA patent/SG11201811309YA/en unknown
- 2017-06-21 AU AU2017281680A patent/AU2017281680B2/en not_active Ceased
- 2017-06-21 CA CA3027810A patent/CA3027810A1/en active Pending
- 2017-06-21 US US16/310,541 patent/US11630420B2/en active Active
- 2017-06-21 WO PCT/FI2017/050463 patent/WO2017220860A1/en active Application Filing
- 2017-06-21 EA EA201892777A patent/EA037743B1/ru not_active IP Right Cessation
-
2019
- 2019-01-21 ZA ZA2019/00411A patent/ZA201900411B/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2110697A1 (de) * | 2008-04-17 | 2009-10-21 | Ruprecht-Karls-Universität Heidelberg | Wellenfeldmikroskop mit Subwellenlängenauflösung und Verfahren zur Bearbeitung mikroskopischer Bilder zur Erkennung von Objekten mit Subwellenlängendimensionen |
WO2011049965A1 (en) * | 2009-10-20 | 2011-04-28 | The Regents Of The University Of California | Incoherent lensfree cell holography and microscopy on a chip |
WO2015166009A1 (fr) * | 2014-04-30 | 2015-11-05 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Procédé et système de détection d'au moins une particule dans un liquide corporel, et procédé associé de diagnostic de la méningite |
CN105547945A (zh) * | 2016-01-14 | 2016-05-04 | 天津大学 | 干涉粒子成像系统采样区内粒子的判别方法 |
Non-Patent Citations (5)
Title |
---|
CHRISTNACHER F. et al. Automatic sizing of particle holographic images via optical correlation and edge extraction. In: Optics Communications 1994, Vol. 108, pp. 17-23, entire document. * |
GUILDENBECHER D. R. et al. Accurate measurement of out-of-plane particle displacement from the cross correlation of sequential digital in-line holograms. In: Optics Letters 2013, Vol. 38, pp. 4015-4018, entire document. * |
MURAKAMI T. A New Direct Analysis Method for Measuring Particle Size and Location by Inline Hologram. In: Laser Diagnostics and Modeling of Combustion, Springer, Berlin, Heidelberg, 1987, pp. 71-76, ISBN 978-3-642-45637-4, pp. 71-76. * |
SOBIERANSKI A. C. et al. Portable lensless wide-field microscopy imaging platform based on digital inline holography and multi-frame pixel super-resolution. In: Light: Science & Applications 2015, Vol. 4, e346, pp. 1-10. * |
STYBAYEVA G. et al. Lensfree Holographic Imaging of Antibody Microarrays for High-Throughput Detection of Leukocyte Numbers and Function. In: Analytical Chemistry 2010, Vol. 82, pp. 3736-3744, entire document. * |
Also Published As
Publication number | Publication date |
---|---|
KR20190022691A (ko) | 2019-03-06 |
EP3260841A1 (de) | 2017-12-27 |
EP3260841B1 (de) | 2024-03-13 |
WO2017220860A1 (en) | 2017-12-28 |
KR102402198B1 (ko) | 2022-05-25 |
CA3027810A1 (en) | 2017-12-28 |
EP3260841C0 (de) | 2024-03-13 |
ZA201900411B (en) | 2022-08-31 |
EA201892777A1 (ru) | 2019-06-28 |
US11630420B2 (en) | 2023-04-18 |
SG11201811309YA (en) | 2019-01-30 |
AU2017281680A1 (en) | 2019-02-07 |
US20190187613A1 (en) | 2019-06-20 |
CN109477782A (zh) | 2019-03-15 |
AU2017281680B2 (en) | 2022-03-17 |
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