EA037743B1 - Обнаружение микроскопических объектов в текучей среде - Google Patents

Обнаружение микроскопических объектов в текучей среде Download PDF

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Publication number
EA037743B1
EA037743B1 EA201892777A EA201892777A EA037743B1 EA 037743 B1 EA037743 B1 EA 037743B1 EA 201892777 A EA201892777 A EA 201892777A EA 201892777 A EA201892777 A EA 201892777A EA 037743 B1 EA037743 B1 EA 037743B1
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EA
Eurasian Patent Office
Prior art keywords
image data
filtered
processed
holographic
microscopic
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Application number
EA201892777A
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English (en)
Russian (ru)
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EA201892777A1 (ru
Inventor
Теро Кести
Эса Хямяляйнен
Original Assignee
Уватер Ой
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Application filed by Уватер Ой filed Critical Уватер Ой
Publication of EA201892777A1 publication Critical patent/EA201892777A1/ru
Publication of EA037743B1 publication Critical patent/EA037743B1/ru

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    • GPHYSICS
    • G03PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03HHOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/04Processes or apparatus for producing holograms
    • G03H1/0443Digital holography, i.e. recording holograms with digital recording means
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02Investigating particle size or size distribution
    • G01N15/0205Investigating particle size or size distribution by optical means
    • G01N15/0227Investigating particle size or size distribution by optical means using imaging; using holography
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484Optical investigation techniques, e.g. flow cytometry microstructural devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41Refractivity; Phase-affecting properties, e.g. optical path length
    • G01N21/45Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods
    • G01N21/453Holographic interferometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84Systems specially adapted for particular applications
    • G01N21/85Investigating moving fluids or granular solids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02Investigating particle size or size distribution
    • G01N15/0205Investigating particle size or size distribution by optical means
    • G01N15/0227Investigating particle size or size distribution by optical means using imaging; using holography
    • G01N2015/0233Investigating particle size or size distribution by optical means using imaging; using holography using holography
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/1029Particle size
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/103Particle shape
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N2021/0378Shapes
    • GPHYSICS
    • G03PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03HHOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/0005Adaptation of holography to specific applications
    • G03H2001/0033Adaptation of holography to specific applications in hologrammetry for measuring or analysing
    • GPHYSICS
    • G03PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03HHOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/0005Adaptation of holography to specific applications
    • G03H2001/0033Adaptation of holography to specific applications in hologrammetry for measuring or analysing
    • G03H2001/0044Adaptation of holography to specific applications in hologrammetry for measuring or analysing holographic fringes deformations; holographic sensors
    • GPHYSICS
    • G03PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03HHOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/04Processes or apparatus for producing holograms
    • G03H1/0443Digital holography, i.e. recording holograms with digital recording means
    • G03H2001/0447In-line recording arrangement

Landscapes

  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Computing Systems (AREA)
  • Theoretical Computer Science (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Holo Graphy (AREA)
  • Image Processing (AREA)
  • Microscoopes, Condenser (AREA)
EA201892777A 2016-06-22 2017-06-21 Обнаружение микроскопических объектов в текучей среде EA037743B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16175687.9A EP3260841B1 (de) 2016-06-22 2016-06-22 Detektion von mikroskopischen objekten in flüssigkeiten
PCT/FI2017/050463 WO2017220860A1 (en) 2016-06-22 2017-06-21 Detecting microscopic objects in fluids

Publications (2)

Publication Number Publication Date
EA201892777A1 EA201892777A1 (ru) 2019-06-28
EA037743B1 true EA037743B1 (ru) 2021-05-17

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201892777A EA037743B1 (ru) 2016-06-22 2017-06-21 Обнаружение микроскопических объектов в текучей среде

Country Status (10)

Country Link
US (1) US11630420B2 (de)
EP (1) EP3260841B1 (de)
KR (1) KR102402198B1 (de)
CN (1) CN109477782A (de)
AU (1) AU2017281680B2 (de)
CA (1) CA3027810A1 (de)
EA (1) EA037743B1 (de)
SG (1) SG11201811309YA (de)
WO (1) WO2017220860A1 (de)
ZA (1) ZA201900411B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108489872B (zh) * 2018-03-23 2022-03-04 奥星制药设备(石家庄)有限公司 在线粒度监测方法和系统
EP3575773A1 (de) * 2018-05-28 2019-12-04 Universität für Bodenkultur Wien Verfahren zur bestimmung einer dreidimensionalen partikelverteilung in einem medium
WO2021011637A1 (en) * 2019-07-15 2021-01-21 Arizona Board Of Regents On Behalf Of The University Of Arizona Complex diversity for accurate phase retrieval with single-shot acquisition
CN116026729B (zh) * 2023-03-03 2024-03-15 浙江大学 一种基于数字同轴全息显微的便携式微塑料检测装置
CN116071689B (zh) * 2023-03-07 2023-06-06 四川三思德科技有限公司 一种基于lora技术的水源地水质在线监测方法及系统
CN117233116B (zh) * 2023-11-09 2024-02-02 江西鼎智检测有限公司 一种基于机器视觉的水质分析方法及系统

Citations (4)

* Cited by examiner, † Cited by third party
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EP2110697A1 (de) * 2008-04-17 2009-10-21 Ruprecht-Karls-Universität Heidelberg Wellenfeldmikroskop mit Subwellenlängenauflösung und Verfahren zur Bearbeitung mikroskopischer Bilder zur Erkennung von Objekten mit Subwellenlängendimensionen
WO2011049965A1 (en) * 2009-10-20 2011-04-28 The Regents Of The University Of California Incoherent lensfree cell holography and microscopy on a chip
WO2015166009A1 (fr) * 2014-04-30 2015-11-05 Commissariat A L'energie Atomique Et Aux Energies Alternatives Procédé et système de détection d'au moins une particule dans un liquide corporel, et procédé associé de diagnostic de la méningite
CN105547945A (zh) * 2016-01-14 2016-05-04 天津大学 干涉粒子成像系统采样区内粒子的判别方法

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CA2450973C (en) 2002-11-27 2013-06-11 Dalhousie University A method for tracking particles and life forms in three dimensions and in time
KR20070030191A (ko) * 2004-04-16 2007-03-15 디시이 아프릴리스, 인코포레이티드 홀로그래픽 매체의 보정피처를 이용한 홀로그래픽데이터저장시스템의 보정
EP2576805A1 (de) * 2010-05-25 2013-04-10 Arryx, Inc. Vorrichtung für holographische fluktuationsmikroskopie und verfahren zur bestimmung der mobilität von partikel- oder zelldispersionen
EP2985719A1 (de) * 2014-08-15 2016-02-17 IMEC vzw System und Verfahren für Zellerkennung
TWI557462B (zh) * 2014-11-28 2016-11-11 台灣愛美科股份有限公司 自動聚焦系統與方法
KR101820563B1 (ko) * 2014-12-31 2018-01-19 한국전자통신연구원 홀로그램 데이터 포맷과 홀로그래픽 비디오 시스템 장치 및 방법
US20170333903A1 (en) * 2016-05-20 2017-11-23 The Board Of Trustees Of The Leland Stanford Junior University Systems and Methods for Automated Single Cell Cytological Classification in Flow

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
EP2110697A1 (de) * 2008-04-17 2009-10-21 Ruprecht-Karls-Universität Heidelberg Wellenfeldmikroskop mit Subwellenlängenauflösung und Verfahren zur Bearbeitung mikroskopischer Bilder zur Erkennung von Objekten mit Subwellenlängendimensionen
WO2011049965A1 (en) * 2009-10-20 2011-04-28 The Regents Of The University Of California Incoherent lensfree cell holography and microscopy on a chip
WO2015166009A1 (fr) * 2014-04-30 2015-11-05 Commissariat A L'energie Atomique Et Aux Energies Alternatives Procédé et système de détection d'au moins une particule dans un liquide corporel, et procédé associé de diagnostic de la méningite
CN105547945A (zh) * 2016-01-14 2016-05-04 天津大学 干涉粒子成像系统采样区内粒子的判别方法

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CHRISTNACHER F. et al. Automatic sizing of particle holographic images via optical correlation and edge extraction. In: Optics Communications 1994, Vol. 108, pp. 17-23, entire document. *
GUILDENBECHER D. R. et al. Accurate measurement of out-of-plane particle displacement from the cross correlation of sequential digital in-line holograms. In: Optics Letters 2013, Vol. 38, pp. 4015-4018, entire document. *
MURAKAMI T. A New Direct Analysis Method for Measuring Particle Size and Location by Inline Hologram. In: Laser Diagnostics and Modeling of Combustion, Springer, Berlin, Heidelberg, 1987, pp. 71-76, ISBN 978-3-642-45637-4, pp. 71-76. *
SOBIERANSKI A. C. et al. Portable lensless wide-field microscopy imaging platform based on digital inline holography and multi-frame pixel super-resolution. In: Light: Science & Applications 2015, Vol. 4, e346, pp. 1-10. *
STYBAYEVA G. et al. Lensfree Holographic Imaging of Antibody Microarrays for High-Throughput Detection of Leukocyte Numbers and Function. In: Analytical Chemistry 2010, Vol. 82, pp. 3736-3744, entire document. *

Also Published As

Publication number Publication date
KR20190022691A (ko) 2019-03-06
EP3260841A1 (de) 2017-12-27
EP3260841B1 (de) 2024-03-13
WO2017220860A1 (en) 2017-12-28
KR102402198B1 (ko) 2022-05-25
CA3027810A1 (en) 2017-12-28
EP3260841C0 (de) 2024-03-13
ZA201900411B (en) 2022-08-31
EA201892777A1 (ru) 2019-06-28
US11630420B2 (en) 2023-04-18
SG11201811309YA (en) 2019-01-30
AU2017281680A1 (en) 2019-02-07
US20190187613A1 (en) 2019-06-20
CN109477782A (zh) 2019-03-15
AU2017281680B2 (en) 2022-03-17

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