EA034563B1 - Способ лечения или предотвращения перегрузки железом у пациента с талассемией - Google Patents

Способ лечения или предотвращения перегрузки железом у пациента с талассемией Download PDF

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Publication number
EA034563B1
EA034563B1 EA201490809A EA201490809A EA034563B1 EA 034563 B1 EA034563 B1 EA 034563B1 EA 201490809 A EA201490809 A EA 201490809A EA 201490809 A EA201490809 A EA 201490809A EA 034563 B1 EA034563 B1 EA 034563B1
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EA
Eurasian Patent Office
Prior art keywords
actriib
polypeptide
seq
amino acid
gdf trap
Prior art date
Application number
EA201490809A
Other languages
English (en)
Russian (ru)
Other versions
EA201490809A1 (ru
Inventor
Джасбир СИХРА
Роберт Скотт Пирсалл
Равиндра КУМАР
Нага Венката Саи Раджасекхар Сурагани
Original Assignee
Акселерон Фарма Инк.
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Application filed by Акселерон Фарма Инк. filed Critical Акселерон Фарма Инк.
Publication of EA201490809A1 publication Critical patent/EA201490809A1/ru
Publication of EA034563B1 publication Critical patent/EA034563B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45Transferases (2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11Protein-serine/threonine kinases (2.7.11)
    • C12Y207/1103Receptor protein serine/threonine kinase (2.7.11.30)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EA201490809A 2011-10-17 2012-10-17 Способ лечения или предотвращения перегрузки железом у пациента с талассемией EA034563B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161547932P 2011-10-17 2011-10-17
PCT/US2012/060650 WO2013059347A1 (en) 2011-10-17 2012-10-17 Methods and compositions for treating ineffective erythropoiesis

Publications (2)

Publication Number Publication Date
EA201490809A1 EA201490809A1 (ru) 2014-09-30
EA034563B1 true EA034563B1 (ru) 2020-02-20

Family

ID=48141315

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201490809A EA034563B1 (ru) 2011-10-17 2012-10-17 Способ лечения или предотвращения перегрузки железом у пациента с талассемией
EA202090053A EA202090053A3 (ru) 2011-10-17 2012-10-17 Способы и композиции для лечения неэффективного эритропоэза

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA202090053A EA202090053A3 (ru) 2011-10-17 2012-10-17 Способы и композиции для лечения неэффективного эритропоэза

Country Status (13)

Country Link
US (4) US20130243743A1 (OSRAM)
EP (3) EP2797620B1 (OSRAM)
JP (4) JP6092883B2 (OSRAM)
KR (4) KR102079482B1 (OSRAM)
CN (3) CN107837390A (OSRAM)
AU (4) AU2012326207B2 (OSRAM)
BR (3) BR112014009528B1 (OSRAM)
CA (1) CA2852683A1 (OSRAM)
DK (2) DK3875104T3 (OSRAM)
EA (2) EA034563B1 (OSRAM)
ES (3) ES3010483T3 (OSRAM)
HK (2) HK1250341A1 (OSRAM)
WO (1) WO2013059347A1 (OSRAM)

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CN103877564A (zh) 2007-09-18 2014-06-25 阿塞勒隆制药公司 活化素-actriia拮抗剂和减少或抑制fsh分泌的用途
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
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CN102482339B (zh) 2009-06-08 2015-06-17 阿塞勒隆制药公司 用于增加产热脂肪细胞的方法
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JP6649895B2 (ja) * 2014-04-18 2020-02-19 アクセルロン ファーマ, インコーポレイテッド 赤血球レベルを増加させ、そして鎌状赤血球症を処置するための方法
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MA41119A (fr) * 2014-12-03 2017-10-10 Acceleron Pharma Inc Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique
RS61881B1 (sr) 2015-04-22 2021-06-30 Biogen Ma Inc Novi hibridni actriib proteini zamke za ligand za lečenje bolesti gubljenja mišića
HK1251157A1 (zh) * 2015-05-13 2019-01-25 细胞基因公司 使用ACTRII配体陷阱治疗β-地中海贫血
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CA3005975A1 (en) 2015-11-23 2017-06-01 Acceleron Pharma Inc. Methods for treating eye disorders
MX2019001043A (es) 2016-07-27 2019-09-26 Acceleron Pharma Inc Metodos y composiciones para el tratamiento de la mielofibrosis.
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JOP20190085A1 (ar) 2016-10-20 2019-04-17 Biogen Ma Inc طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة
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JP7496686B2 (ja) * 2017-06-14 2024-06-07 セルジーン コーポレイション 骨髄増殖性腫瘍関連骨髄線維症及び貧血を治療するための方法
CA3082146A1 (en) 2017-11-09 2019-05-16 Keros Therapeutics, Inc. Activin receptor type iia variants and methods of use thereof
CN120399032A (zh) 2018-01-12 2025-08-01 科乐斯疗法公司 激活素受体iib型变体及其使用方法
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Also Published As

Publication number Publication date
US20170137791A1 (en) 2017-05-18
US20170327800A1 (en) 2017-11-16
AU2017201580A1 (en) 2017-03-30
EP3520805B1 (en) 2021-03-10
CN107693776A (zh) 2018-02-16
EP2797620A4 (en) 2015-05-20
CN103987403B (zh) 2017-12-01
AU2017201580B2 (en) 2018-07-12
CN103987403A (zh) 2014-08-13
BR122019023166B1 (pt) 2021-02-23
US20130243743A1 (en) 2013-09-19
JP6796626B2 (ja) 2020-12-09
DK3520805T3 (da) 2021-04-19
AU2018247262B2 (en) 2020-12-24
CN107837390A (zh) 2018-03-27
EA202090053A2 (ru) 2020-04-30
EA202090053A3 (ru) 2020-06-30
BR112014009528B1 (pt) 2020-12-29
HK1203413A1 (en) 2015-10-30
KR20220075438A (ko) 2022-06-08
AU2012326207A1 (en) 2014-05-15
EA201490809A1 (ru) 2014-09-30
EP3520805A1 (en) 2019-08-07
EP2797620A1 (en) 2014-11-05
AU2020286229A1 (en) 2021-01-07
KR102079482B1 (ko) 2020-02-19
BR122019023174B1 (pt) 2021-02-23
KR20190105113A (ko) 2019-09-11
BR112014009528A8 (pt) 2019-12-10
EP2797620B1 (en) 2019-04-24
WO2013059347A1 (en) 2013-04-25
JP2014530253A (ja) 2014-11-17
JP2020186277A (ja) 2020-11-19
ES3010483T3 (en) 2025-04-03
US20210207107A1 (en) 2021-07-08
AU2012326207B2 (en) 2016-12-15
JP6092883B2 (ja) 2017-03-08
EP3875104B1 (en) 2025-01-22
HK1252940A1 (zh) 2019-06-06
AU2018247262A1 (en) 2018-11-01
ES2869168T3 (es) 2021-10-25
DK3875104T3 (da) 2025-02-03
CA2852683A1 (en) 2013-04-25
KR20140084211A (ko) 2014-07-04
KR20200019261A (ko) 2020-02-21
JP6383821B2 (ja) 2018-08-29
ES2741477T3 (es) 2020-02-11
JP2018165287A (ja) 2018-10-25
HK1250341A1 (zh) 2018-12-14
JP2017101060A (ja) 2017-06-08
EP3875104A1 (en) 2021-09-08
BR112014009528A2 (pt) 2017-05-09

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