EA033191B1 - Применение неридроновой кислоты или ее соли для лечения остеоартрита - Google Patents

Применение неридроновой кислоты или ее соли для лечения остеоартрита

Info

Publication number
EA033191B1
EA033191B1 EA201790531A EA201790531A EA033191B1 EA 033191 B1 EA033191 B1 EA 033191B1 EA 201790531 A EA201790531 A EA 201790531A EA 201790531 A EA201790531 A EA 201790531A EA 033191 B1 EA033191 B1 EA 033191B1
Authority
EA
Eurasian Patent Office
Prior art keywords
osteoarthritis
salt
neridronic acid
treatment
symptoms
Prior art date
Application number
EA201790531A
Other languages
English (en)
Other versions
EA201790531A1 (ru
Inventor
Варенна Массимо
Original Assignee
Абиоген Фарма Спа
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51904075&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA033191(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Абиоген Фарма Спа filed Critical Абиоген Фарма Спа
Publication of EA201790531A1 publication Critical patent/EA201790531A1/ru
Publication of EA033191B1 publication Critical patent/EA033191B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

В изобретении описано применение неридроновой кислоты или ее соли для лечения остеоартрита. В частности, было показано, что неридроновая кислота или ее соль способны значительно уменьшать выраженность симптомов остеоартрита, таких как боль, ограничения трудоспособности и подвижности, а также уменьшать субхондральные повреждения костного мозга, лежащие в основе возникновения указанных симптомов.
EA201790531A 2014-10-15 2015-10-15 Применение неридроновой кислоты или ее соли для лечения остеоартрита EA033191B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI20141794 2014-10-15
PCT/IB2015/057929 WO2016059594A1 (en) 2014-10-15 2015-10-15 Use of neridronic acid or of its salt for the treatment of osteoarthrosis

Publications (2)

Publication Number Publication Date
EA201790531A1 EA201790531A1 (ru) 2017-08-31
EA033191B1 true EA033191B1 (ru) 2019-09-30

Family

ID=51904075

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790531A EA033191B1 (ru) 2014-10-15 2015-10-15 Применение неридроновой кислоты или ее соли для лечения остеоартрита

Country Status (32)

Country Link
US (2) US20170209470A1 (ru)
EP (1) EP3206694B1 (ru)
JP (1) JP6839076B2 (ru)
KR (1) KR102591084B1 (ru)
CN (2) CN106794190A (ru)
AU (1) AU2015332060B2 (ru)
BR (1) BR112017006989A2 (ru)
CA (1) CA2963066C (ru)
CL (1) CL2017000915A1 (ru)
CO (1) CO2017003561A2 (ru)
CY (1) CY1123420T1 (ru)
DK (1) DK3206694T3 (ru)
DO (1) DOP2017000096A (ru)
EA (1) EA033191B1 (ru)
EC (1) ECSP17023093A (ru)
ES (1) ES2819186T3 (ru)
HR (1) HRP20201475T1 (ru)
HU (1) HUE052088T2 (ru)
IL (1) IL251421B (ru)
LT (1) LT3206694T (ru)
MX (1) MX2017004826A (ru)
MY (1) MY191481A (ru)
NZ (1) NZ730853A (ru)
PE (1) PE20170699A1 (ru)
PH (1) PH12017500659A1 (ru)
PL (1) PL3206694T3 (ru)
PT (1) PT3206694T (ru)
RS (1) RS60868B1 (ru)
SG (1) SG11201702574XA (ru)
SI (1) SI3206694T1 (ru)
TN (1) TN2017000095A1 (ru)
WO (1) WO2016059594A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190328755A1 (en) * 2018-04-30 2019-10-31 Grunenthal Gmbh Methods of treating complex regional pain syndrome (crps) or symptoms comprising administration of neridronic acid

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005074944A1 (en) * 2004-02-10 2005-08-18 Abiogen Pharma S.P.A. Use of sodium neridronate to promote new bone formation
WO2005107751A1 (en) * 2004-05-06 2005-11-17 Merck & Co., Inc. Methods for treating arthritic conditions in dogs
WO2007092338A2 (en) * 2006-02-06 2007-08-16 Cypress Bioscience, Inc. Compositions comprising a bisphosphonate and an antifolate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070191315A1 (en) * 2006-02-16 2007-08-16 Bengt Bergstrom Method for administering ibandronate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005074944A1 (en) * 2004-02-10 2005-08-18 Abiogen Pharma S.P.A. Use of sodium neridronate to promote new bone formation
WO2005107751A1 (en) * 2004-05-06 2005-11-17 Merck & Co., Inc. Methods for treating arthritic conditions in dogs
WO2007092338A2 (en) * 2006-02-06 2007-08-16 Cypress Bioscience, Inc. Compositions comprising a bisphosphonate and an antifolate

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ADAMI S, ET AL.: "SHORT-TERM INTRAVENOUS THERAPY WITH NERIDRONATE IN PAGET'S DISEASE", CLINICAL AND EXPERIMENTAL RHEUMATOLOGY., PACINI, PISA, IT, vol. 20, no. 01, 1 January 2002 (2002-01-01), IT, pages 55 - 58, XP008048855, ISSN: 0392-856X *
ADDOLORATA CORRADO ; FRANCESCO PAOLO CANTATORE ; MARIA GRANO ; SILVIA COLUCCI: "Neridronate and human osteoblasts in normal, osteoporotic and osteoarthritic subjects", CLINICAL RHEUMATOLOGY ; JOURNAL OF THE INTERNATIONAL LEAGUE OF ASSOCIATIONS FOR RHEUMATOLOGY, SPRINGER-VERLAG, LO, vol. 24, no. 5, 1 October 2005 (2005-10-01), Lo, pages 527 - 534, XP019381675, ISSN: 1434-9949, DOI: 10.1007/s10067-005-1100-2 *
SIEBELT M.; WAARSING J.H.; GROEN H.C.; M�LLER C.; KOELEWIJN S.J.; DE BLOIS E.; VERHAAR J.A.N.; DE JONG M.; WEINANS H.: "Inhibited osteoclastic bone resorption through alendronate treatment in rats reduces severe osteoarthritis progression", BONE, PERGAMON PRESS., OXFORD, GB, vol. 66, 13 June 2014 (2014-06-13), GB, pages 163 - 170, XP029013395, ISSN: 8756-3282, DOI: 10.1016/j.bone.2014.06.009 *
SPECTOR TIM D; CONAGHAN PHILIP G; BUCKLAND-WRIGHT J CHRISTOPHER; GARNERO PATRICK; CLINE GARY A; BEARY JOHN F; VALENT DAVID J; MEYE: "Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]", ARTHRITIS RESEARCH, CURRENT SCIENCE, LONDON,, GB, vol. 7, no. 3, 24 March 2005 (2005-03-24), GB, pages R625 - R633, XP021011601, ISSN: 1465-9905, DOI: 10.1186/ar1716 *
VARENNA M, ADAMI S, ROSSINI M, GATTI D, IDOLAZZI L, ZUCCHI F, MALAVOLTA N, SINIGAGLIA L.: "Treatment of complex regional pain syndrome type I with neridronate: a randomized, double-blind, placebo-controlled study.", RHEUMATOLOGY, OXFORD UNIVERSITY PRESS, UNITED KINGDOM, UNITED STATES, NETHERLANDS, vol. 52, no. 3, 1 March 2013 (2013-03-01), United Kingdom, United States, Netherlands, pages 534 - 542, XP002734047, ISSN: 1462-0332, DOI: 10.1093/rheumatology/kes312 *

Also Published As

Publication number Publication date
JP6839076B2 (ja) 2021-03-03
CA2963066C (en) 2023-12-05
EP3206694B1 (en) 2020-07-08
US20170209470A1 (en) 2017-07-27
BR112017006989A2 (pt) 2018-03-27
CL2017000915A1 (es) 2017-11-10
RS60868B1 (sr) 2020-11-30
HUE052088T2 (hu) 2021-04-28
JP2017532333A (ja) 2017-11-02
PE20170699A1 (es) 2017-06-03
IL251421B (en) 2022-05-01
NZ730853A (en) 2018-06-29
HRP20201475T1 (hr) 2020-12-11
AU2015332060A1 (en) 2017-04-27
CN111939164A (zh) 2020-11-17
KR102591084B1 (ko) 2023-10-18
MY191481A (en) 2022-06-28
ECSP17023093A (es) 2017-06-30
LT3206694T (lt) 2020-11-25
TN2017000095A1 (en) 2018-07-04
CA2963066A1 (en) 2016-04-21
CN106794190A (zh) 2017-05-31
DOP2017000096A (es) 2017-07-31
EA201790531A1 (ru) 2017-08-31
KR20170066438A (ko) 2017-06-14
ES2819186T3 (es) 2021-04-15
SI3206694T1 (sl) 2020-11-30
PH12017500659A1 (en) 2017-10-02
SG11201702574XA (en) 2017-04-27
AU2015332060B2 (en) 2018-06-07
CO2017003561A2 (es) 2017-09-11
IL251421A0 (en) 2017-05-29
PL3206694T3 (pl) 2020-12-28
EP3206694A1 (en) 2017-08-23
WO2016059594A1 (en) 2016-04-21
PT3206694T (pt) 2020-09-22
MX2017004826A (es) 2018-01-24
CY1123420T1 (el) 2021-12-31
US20230233585A1 (en) 2023-07-27
DK3206694T3 (da) 2020-09-21

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KG TJ TM