EA033123B1 - Антипролиферативная и антиметастатическая фармацевтическая композиция и способ лечения рака - Google Patents

Антипролиферативная и антиметастатическая фармацевтическая композиция и способ лечения рака

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Publication number
EA033123B1
EA033123B1 EA201691018A EA201691018A EA033123B1 EA 033123 B1 EA033123 B1 EA 033123B1 EA 201691018 A EA201691018 A EA 201691018A EA 201691018 A EA201691018 A EA 201691018A EA 033123 B1 EA033123 B1 EA 033123B1
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EA
Eurasian Patent Office
Prior art keywords
proliferative
pharmaceutical composition
produced
treating cancer
chymotrypsinogen
Prior art date
Application number
EA201691018A
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English (en)
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EA201691018A1 (ru
EA033123B9 (ru
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Франтишек Трнка
Павел Долезаль
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Франтишек Трнка
Павел Долезаль
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Application filed by Франтишек Трнка, Павел Долезаль filed Critical Франтишек Трнка
Publication of EA201691018A1 publication Critical patent/EA201691018A1/ru
Publication of EA033123B1 publication Critical patent/EA033123B1/ru
Publication of EA033123B9 publication Critical patent/EA033123B9/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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Abstract

Предложены антипролиферативная и антиметастатическая фармацевтическая композиция для терапевтического, профилактического и диагностического применения у млекопитающих, содержащая трипсиноген (T), химотрипсиноген типа A (CH), α-амилазу, продуцируемую Bacillus sp. (A), липазу, полученную из Triticum aestivum (L), где отношение активностей T:CH:A:L, выраженное в ME (международных единицах), находится в диапазоне от 150:150:40:1 до 400:1200:200:1, и один или несколько фармацевтически приемлемых эксципиентов, и способ лечения рака молочной железы, колоректального рака, рака предстательной железы и мелкоклеточного рака легких, включающий одновременное, раздельное и последовательное введение трипсиногена (T), химотрипсиногена типа A (CH), α-амилазы, продуцируемой Bacillus sp., (A) и липазы, полученной из Triticum aestivum, (L), где отношение T:CH:A:L соответствует указанному выше.
EA201691018A 2013-11-18 2014-11-12 Антипролиферативная и антиметастатическая фармацевтическая композиция и способ лечения рака EA033123B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ2013-891A CZ307195B6 (cs) 2013-11-18 2013-11-18 Farmaceutická kompozice obsahující směs proenzymů a enzymů
PCT/CZ2014/000133 WO2015070828A1 (en) 2013-11-18 2014-11-12 Pharmaceutical composition containing a mixture of proenzymes and enzymes

Publications (3)

Publication Number Publication Date
EA201691018A1 EA201691018A1 (ru) 2016-11-30
EA033123B1 true EA033123B1 (ru) 2019-08-30
EA033123B9 EA033123B9 (ru) 2019-10-31

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ID=67353809

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EA201691018A EA033123B9 (ru) 2013-11-18 2014-11-12 Антипролиферативная и антиметастатическая фармацевтическая композиция и способ лечения рака

Country Status (16)

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US (2) US20160339085A1 (ru)
EP (1) EP3071218B1 (ru)
JP (1) JP6568095B2 (ru)
CY (1) CY1121276T1 (ru)
CZ (1) CZ307195B6 (ru)
DK (1) DK3071218T3 (ru)
EA (1) EA033123B9 (ru)
ES (1) ES2707376T3 (ru)
HR (1) HRP20182155T1 (ru)
HU (1) HUE042667T2 (ru)
LT (1) LT3071218T (ru)
PL (1) PL3071218T3 (ru)
PT (1) PT3071218T (ru)
RS (1) RS58296B1 (ru)
SI (1) SI3071218T1 (ru)
WO (1) WO2015070828A1 (ru)

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US11185587B2 (en) 2013-11-18 2021-11-30 Frantisek Trnka Pharmaceutical composition containing a mixture of proenzymes and enzymes

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SG11201803531XA (en) * 2015-11-12 2018-05-30 Propanc Pty Ltd Proenzyme composition
CN105385669A (zh) * 2015-11-24 2016-03-09 青岛康原药业有限公司 一种二次亲和层析法提取激肽释放酶原的方法及提高激肽释放酶原稳定性的药物组合物
MY198500A (en) 2016-01-29 2023-09-01 Propanc Pty Ltd Cancer treatment
CN109152823A (zh) * 2016-04-12 2019-01-04 普罗潘克股份有限公司 用于癌症治疗的酶原的组合物
DK3335696T3 (da) * 2016-12-15 2020-03-16 Upm Kymmene Corp Fremgangsmåde til tørring af cellefrit vævsekstrakt i en hydrogel omfattende nanofibrillær cellulose og en tørret hydrogel omfattende nanofibrillær cellulose og cellefrit vævsekstrakt
WO2021009768A1 (en) * 2019-07-12 2021-01-21 Lovely Professional University An oral pharmaceutical composition for alpha- amylase inhibition
CA3157209A1 (en) * 2019-10-08 2021-04-15 Afyx Therapeutics A/S Compositions for the delivery of proteins

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