EA033085B1 - Производные 2-(1-гетероарилпиперазин-4-ил)метил-1,4- бензодиоксана в качестве альфа2c-антагонистов - Google Patents

Производные 2-(1-гетероарилпиперазин-4-ил)метил-1,4- бензодиоксана в качестве альфа2c-антагонистов

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Publication number
EA033085B1
EA033085B1 EA201792670A EA201792670A EA033085B1 EA 033085 B1 EA033085 B1 EA 033085B1 EA 201792670 A EA201792670 A EA 201792670A EA 201792670 A EA201792670 A EA 201792670A EA 033085 B1 EA033085 B1 EA 033085B1
Authority
EA
Eurasian Patent Office
Prior art keywords
heteroarylpiperazin
methyl
benzodioxane derivatives
alpha2c antagonists
alpha2c
Prior art date
Application number
EA201792670A
Other languages
English (en)
Other versions
EA201792670A1 (ru
Inventor
Шоумин Ван
Эса Кумпулаинен
Ярмо Пюстюнен
Антти Похякаллио
Ансси Хайкарайнен
Original Assignee
Орион Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Орион Корпорейшн filed Critical Орион Корпорейшн
Publication of EA201792670A1 publication Critical patent/EA201792670A1/ru
Publication of EA033085B1 publication Critical patent/EA033085B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

В изобретении раскрываются соединения формулы Iгде A является необязательно замещенным 5-членным ненасыщенным гетероциклическим кольцом, содержащим 1, 2 или 3 гетероатома N, O и S в кольце, которые демонстрируют альфа2C-антагонистическую активность и, таким образом, могут применяться для лечения заболеваний или состояний переферической или центральной нервной системы.
EA201792670A 2015-06-05 2016-06-03 Производные 2-(1-гетероарилпиперазин-4-ил)метил-1,4- бензодиоксана в качестве альфа2c-антагонистов EA033085B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20150169 2015-06-05
PCT/FI2016/050400 WO2016193551A1 (en) 2015-06-05 2016-06-03 2-(1-heteroarylpiperazin-4-yl)methyl-1,4-benzodioxane derivatives as alpha2c antagonists

Publications (2)

Publication Number Publication Date
EA201792670A1 EA201792670A1 (ru) 2018-04-30
EA033085B1 true EA033085B1 (ru) 2019-08-30

Family

ID=56132965

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201792670A EA033085B1 (ru) 2015-06-05 2016-06-03 Производные 2-(1-гетероарилпиперазин-4-ил)метил-1,4- бензодиоксана в качестве альфа2c-антагонистов

Country Status (16)

Country Link
US (1) US10774074B2 (ru)
EP (1) EP3303327B1 (ru)
JP (1) JP6806711B2 (ru)
KR (1) KR102653543B1 (ru)
CN (1) CN107709316B (ru)
AR (1) AR104882A1 (ru)
AU (1) AU2016272220B2 (ru)
CA (1) CA2985400C (ru)
EA (1) EA033085B1 (ru)
ES (1) ES2794584T3 (ru)
IL (1) IL255352B (ru)
MX (1) MX2017015572A (ru)
NZ (1) NZ737533A (ru)
TW (1) TWI704145B (ru)
WO (1) WO2016193551A1 (ru)
ZA (1) ZA201707466B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201990158A1 (ru) * 2016-06-29 2019-05-31 Орион Корпорейшн Производные бензодиоксана и их фармацевтическое применение
WO2023131638A1 (en) 2022-01-07 2023-07-13 Bayer Aktiengesellschaft 2,3-dihydrobenzo [b][1, 4]dioxin-2-ylmethyl)piperazin-1-yl derivates for the treatment of sleep apnea

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4590196A (en) * 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
WO2010058060A1 (en) * 2008-11-20 2010-05-27 Orion Corporation Aryl piperazine and their use as alpha2c antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE788052A (fr) 1971-08-26 1973-02-26 Science Union & Cie Societe Fr Nouveaux derives de la sydnone imine
GB2167408B (en) 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
US20040259883A1 (en) 2001-09-14 2004-12-23 Hiroshi Sakashita Thiazolidine derivative and medicinal use thereof
US7592350B2 (en) 2002-04-03 2009-09-22 Orion Corporation Polycyclic compounds as potent alpha2-adrenoceptor antagonists
EP2280003B1 (en) 2002-07-15 2014-04-02 Symphony Evolution, Inc. Process for preparing receptor-type kinase modulators
JP4960085B2 (ja) 2003-03-19 2012-06-27 エクセリクシス， インク． Ｔｉｅ−２モジュレータと使用方法
TWI457122B (zh) 2007-07-20 2014-10-21 Orion Corp 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4590196A (en) * 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
WO2010058060A1 (en) * 2008-11-20 2010-05-27 Orion Corporation Aryl piperazine and their use as alpha2c antagonists

Also Published As

Publication number Publication date
JP2018520123A (ja) 2018-07-26
AR104882A1 (es) 2017-08-23
EP3303327A1 (en) 2018-04-11
AU2016272220A1 (en) 2017-11-16
CA2985400C (en) 2023-08-29
AU2016272220B2 (en) 2020-05-21
KR102653543B1 (ko) 2024-04-03
TW201708208A (zh) 2017-03-01
EP3303327B1 (en) 2020-03-11
WO2016193551A1 (en) 2016-12-08
CN107709316B (zh) 2021-08-17
CN107709316A (zh) 2018-02-16
US20190292170A9 (en) 2019-09-26
TWI704145B (zh) 2020-09-11
IL255352B (en) 2021-03-25
IL255352A0 (en) 2017-12-31
CA2985400A1 (en) 2016-12-08
NZ737533A (en) 2024-03-22
ZA201707466B (en) 2018-11-28
US10774074B2 (en) 2020-09-15
JP6806711B2 (ja) 2021-01-06
ES2794584T3 (es) 2020-11-18
MX2017015572A (es) 2018-04-30
US20180215739A1 (en) 2018-08-02
KR20180011316A (ko) 2018-01-31
EA201792670A1 (ru) 2018-04-30

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